Behavioural and cellular effects of exogenous amyloid-β peptides in rodents.

Abstract:

:A better understanding of Alzheimer's disease (AD) and the development of disease modifying therapies are some of the biggest challenges of the 21st century. One of the core features of AD are amyloid plaques composed of amyloid-beta (Aβ) peptides. The first hypothesis proposed that cognitive deficits are linked to plaque-development and transgenic mice have been generated to study this link, thereby providing a good model to develop new therapeutic approaches. Since later it was recognised that in AD patients the cognitive deficit is rather correlated to soluble amyloid levels, consequently, a new hypothesis appeared associating the earliest amyloid toxicity to these soluble species. The purpose of this review is to give a summary of behavioural and cellular data obtained after soluble Aβ peptide administration into rodents' brain, thereby showing that this model is a valid tool to investigate AD pathology when no plaques are present. Additionally, this method offers an excellent, efficient model to test compounds which could act at such early stages of the disease.

journal_name

Behav Brain Res

authors

Chambon C,Wegener N,Gravius A,Danysz W

doi

10.1016/j.bbr.2011.08.024

subject

Has Abstract

pub_date

2011-12-01 00:00:00

pages

623-41

issue

2

eissn

0166-4328

issn

1872-7549

pii

S0166-4328(11)00616-4

journal_volume

225

pub_type

杂志文章,评审
  • Decaffeinated coffee prevents scopolamine-induced memory impairment in rats.

    abstract:INTRODUCTION:Several human studies have reported that coffee consumption improves cognitive performance. In the present study, we investigated whether instant decaffeinated coffee also ameliorates cognitive performance and attenuates the detrimental effects of scopolamine on memory. METHODS:Memory performance was eval...

    journal_title:Behavioural brain research

    pub_type: 杂志文章

    doi:10.1016/j.bbr.2013.02.003

    authors: Jang YJ,Kim J,Shim J,Kim CY,Jang JH,Lee KW,Lee HJ

    更新日期:2013-05-15 00:00:00

  • Exercise effects on motor and affective behavior and catecholamine neurochemistry in the MPTP-lesioned mouse.

    abstract::This study used 1-methyl-4-phenyl-1,2,3,6,-tetrahydropyridine (MPTP) in mice to determine if exercise improves behavior and dopamine (DA) and serotonin (5HT) content. Male C57BL/6 mice received MPTP (4 x 20mg/kg) or saline. They remained sedentary or exercised by treadmill or voluntary running wheel for 6 weeks (n=8/g...

    journal_title:Behavioural brain research

    pub_type: 杂志文章

    doi:10.1016/j.bbr.2010.05.009

    authors: Gorton LM,Vuckovic MG,Vertelkina N,Petzinger GM,Jakowec MW,Wood RI

    更新日期:2010-12-01 00:00:00

  • Evidence for a long-term protection of wheel-running exercise against cocaine psychomotor sensitization in adolescent but not in adult mice.

    abstract::Rodents housed with a running wheel can exhibit attenuated cocaine seeking and cocaine-induced psychomotor activation. However, the longevity of such a protection and the influence of the developmental stage during which exercise is displayed received little attention. Here, females and males C57BL/6J mice, aged 28 (a...

    journal_title:Behavioural brain research

    pub_type: 杂志文章

    doi:10.1016/j.bbr.2018.04.054

    authors: Lespine LF,Tirelli E

    更新日期:2018-09-03 00:00:00

  • Inability to acquire spatial information and deploy spatial search strategies in mice with lesions in dorsomedial striatum.

    abstract::Dorsal striatum has been shown to contribute to spatial learning and memory, but the role of striatal subregions in this important aspect of cognitive functioning remains unclear. Moreover, the spatial-cognitive mechanisms that underlie the involvement of these regions in spatial navigation have scarcely been studied....

    journal_title:Behavioural brain research

    pub_type: 杂志文章

    doi:10.1016/j.bbr.2015.11.001

    authors: Pooters T,Gantois I,Vermaercke B,D'Hooge R

    更新日期:2016-02-01 00:00:00

  • Synthetic cathinones and their phenethylamine analogues produce distinct psychomotor and reward behavior in crayfish.

    abstract::Synthetic cathinones share potent sympathomimetic properties with amphetamines due to their shared phenethylamine backbone. Despite recent work focused on understanding the behavioral effects of synthetic cathinones, a systematic comparison of neuropharmacology, behavior, and physiological effects with other stimulant...

    journal_title:Behavioural brain research

    pub_type: 杂志文章

    doi:10.1016/j.bbr.2019.112368

    authors: Gore S,van Staaden MJ,Sprague JE,Huber R

    更新日期:2020-02-03 00:00:00

  • Interocular transfer of habituation in pigeons: mediation by tectal and/or posterior commissures.

    abstract::Interocular transfer of the habituation to diffuse photic stimuli was demonstrated to be almost complete in pigeons. Birds submitted to visual Wulst ablation or supraoptic commissure lesion performed in much the same way. In contrast, when the tectal and posterior commissures were lesioned, pigeons failed to show inte...

    journal_title:Behavioural brain research

    pub_type: 杂志文章

    doi:10.1016/0166-4328(87)90054-4

    authors: Hamassaki DE,Britto LR

    更新日期:1987-02-01 00:00:00

  • Anxiolytic actions of diazepam, but not of buspirone, are influenced by gender and the endocrine stage.

    abstract::The effect of diazepam (1.0 mg/kg, i.p.) and buspirone (5.0 mg/kg, i.p.) on the burying behaviour latency (denoting actions on the animals' reactivity) and on the cumulative burying behaviour (directly reflecting the experimental anxiety levels), were analyzed in male-, intact females, at proestrus and metoestrus, and...

    journal_title:Behavioural brain research

    pub_type: 杂志文章

    doi:10.1016/s0166-4328(97)00047-8

    authors: Fernández-Guasti A,Picazo O

    更新日期:1997-11-01 00:00:00

  • Differential roles of GABAB1 subunit isoforms on locomotor responses to acute and repeated administration of cocaine.

    abstract::GABAB receptors are crucial modulators of the behavioural effects of drug abuse, and agonists and positive allosteric modulators show promise as pharmacological strategies for anti-addiction therapeutics. GABAB receptors are functional heterodimers of GABAB1 and GABAB2 subunits. The predominant neuronal GABAB1 subunit...

    journal_title:Behavioural brain research

    pub_type: 杂志文章

    doi:10.1016/j.bbr.2015.10.039

    authors: Jacobson LH,Sweeney FF,Kaupmann K,O'Leary OF,Gassmann M,Bettler B,Cryan JF

    更新日期:2016-02-01 00:00:00

  • Relevance of electroencephalogram assessment in amyloid and tau pathology in rat.

    abstract::In order to contribute to a better knowledge on the relationship between amyloid and tau pathology, and electroencephalography (EEG) disturbances, the aim of this study was to evaluate the effects of injection of beta amyloid Abeta(1-42) peptide, tau (a recombinant AAV (Adeno-Associated Virus) containing the human tra...

    journal_title:Behavioural brain research

    pub_type: 杂志文章

    doi:10.1016/j.bbr.2018.10.026

    authors: Maleysson V,Page G,Janet T,Klein RL,Haida O,Maurin A,Richard S,Champeroux P,Fauconneau B

    更新日期:2019-02-01 00:00:00

  • Development of early motor learning and topical motor skills in a model of cerebellar degeneration.

    abstract::The development of motor learning and topical motor skills has been studied during the first month of life in neurodeficient Lurcher mutant mice derived from C3H strain. The examination of motor functions was conducted using four methods when animals were consecutively placed on: a horizontal wire, a rotating cylinder...

    journal_title:Behavioural brain research

    pub_type: 杂志文章

    doi:10.1016/S0166-4328(03)00247-X

    authors: Krízková A,Vozeh F

    更新日期:2004-04-02 00:00:00

  • Exposure to enriched environments increases brain nitric oxide synthase and improves cognitive performance in prepubertal but not in young rats.

    abstract::Rats were randomly assigned to enriched (EE) or standard environments (SE) at 21 or 73 days of age, for 17 days. Half of the rats of each rearing condition were trained in a radial maze (RM). At 38 days (pre-pubertal) or 90 days (young), rats were sacrificed and brain cytosolic and mitochondrial nitric oxide synthase ...

    journal_title:Behavioural brain research

    pub_type: 杂志文章

    doi:10.1016/j.bbr.2007.06.024

    authors: Lores-Arnaiz S,Bustamante J,Czernizyniec A,Galeano P,González Gervasoni M,Rodil Martínez A,Paglia N,Cores V,Lores-Arnaiz MR

    更新日期:2007-12-03 00:00:00

  • Conditional cross-correlation analysis of thalamocortical neurotransmission.

    abstract::We developed a method to quantify the probability of a target neuron discharge following synchronous or asynchronous discharges among a pair of reference neurons. To illustrate this method, we simultaneously recorded three neurons having overlapping receptive fields in the somatosensory system: two reference neurons i...

    journal_title:Behavioural brain research

    pub_type: 杂志文章

    doi:10.1016/s0166-4328(02)00165-1

    authors: Alloway KD,Roy SA

    更新日期:2002-09-20 00:00:00

  • Effects of nicotine exposure on locomotor activity and pCREB levels in the ventral striatum of adolescent rats.

    abstract::Behavioral reactivity to novel stimuli, which is greater in the adolescent than young adult population, is associated with drug abuse liability, suggesting that the increased addiction vulnerability of adolescents may be related to heightened novel stimulus reactivity and underlying cellular processes. We examined the...

    journal_title:Behavioural brain research

    pub_type: 杂志文章

    doi:10.1016/j.bbr.2012.01.036

    authors: Philpot RM,Engberg ME,Wecker L

    更新日期:2012-04-21 00:00:00

  • Effects of antihypertensive drugs on ultrasound production and cardiovascular responses in 15-day-old rats.

    abstract::When exposed to extreme cold or injected with the alpha(2)-adrenoceptor agonist, clonidine, infant rats emit ultrasonic vocalizations (USVs). Based upon the cardiovascular changes that accompany these two manipulations, especially decreased venous return, it was hypothesized that USVs are the acoustic by-product of th...

    journal_title:Behavioural brain research

    pub_type: 杂志文章

    doi:10.1016/s0166-4328(01)00369-2

    authors: Blumberg MS,Sokoloff G,Kirby RF,Knoot TG,Lewis SJ

    更新日期:2002-04-01 00:00:00

  • Dopamine-rich transplants in rats with 6-OHDA lesions of the ventral tegmental area. I. Effects on spontaneous and drug-induced locomotor activity.

    abstract::In order to investigate the relative contribution of dopaminergic projections to the nucleus accumbens and prefrontal cortex in the regulation of spontaneous and drug-induced locomotor activity, separate groups of rats were prepared with 6-OHDA lesions of the ventral tegmental area alone, or additional grafts of dopam...

    journal_title:Behavioural brain research

    pub_type: 杂志文章

    doi:10.1016/0166-4328(84)90031-7

    authors: Dunnett SB,Bunch ST,Gage FH,Björklund A

    更新日期:1984-07-01 00:00:00

  • Limbic system activation is affected by prenatal predator exposure and postnatal environmental enrichment and further moderated by dam and sex.

    abstract::Epilepsy is a relatively common and chronic neurological condition, affecting 1-2% of the population. However, understanding of the underlying pathophysiology remains incomplete. To identify potential factors in the early environment that may increase the risk for experiencing seizures, maternal stress and environment...

    journal_title:Behavioural brain research

    pub_type: 杂志文章

    doi:10.1016/j.bbr.2013.10.037

    authors: Korgan AC,Green AD,Perrot TS,Esser MJ

    更新日期:2014-02-01 00:00:00

  • Interactions among ovarian hormones and time of testing on behavioral sensitization and cocaine self-administration.

    abstract::Ovarian hormones play a role in the use of drugs of abuse in women. In female rats estradiol has been shown to enhance acquisition of cocaine self-administration and behavioral sensitization induced by repeated cocaine treatment. Experiments were conducted to determine the effects of estradiol and/or progesterone on c...

    journal_title:Behavioural brain research

    pub_type: 杂志文章

    doi:10.1016/j.bbr.2007.07.005

    authors: Yang H,Zhao W,Hu M,Becker JB

    更新日期:2007-12-03 00:00:00

  • Early social stress in female guinea pigs induces a masculinization of adult behavior and corresponding changes in brain and neuroendocrine function.

    abstract::This study was undertaken to investigate, in guinea pigs, the effects of pre- and early postnatal social stress on the functioning of hormonal-, autonomic-, behavioral-, and limbic-brain systems. Dams had either lived in groups with a constant composition (i.e. stable social environment) or in groups with changing com...

    journal_title:Behavioural brain research

    pub_type: 杂志文章

    doi:10.1016/s0166-4328(03)00077-9

    authors: Kaiser S,Kruijver FP,Swaab DF,Sachser N

    更新日期:2003-09-15 00:00:00

  • Remote ischemic post-conditioning improves neurological function by AQP4 down-regulation in astrocytes.

    abstract::Cerebral ischemia is a primary cause of human death and long-term disability. Previous studies have suggested that remote ischemic post-conditioning (RIPC) is a potential useful tool for cerebral ischemic treatment. However, the protective mechanism of RIPC is not very clear. This study verified the hypothesis that, i...

    journal_title:Behavioural brain research

    pub_type: 杂志文章,评审

    doi:10.1016/j.bbr.2015.04.024

    authors: Li S,Hu X,Zhang M,Zhou F,Lin N,Xia Q,Zhou Y,Qi W,Zong Y,Yang H,Wang T

    更新日期:2015-08-01 00:00:00

  • Specialized face processing and hemispheric asymmetry in man and monkey: evidence from single unit and reaction time studies.

    abstract::Experimental and clinical studies have generally shown that the neural mechanisms for face processing in man are (1) designed to deal with the configuration of upright faces and (2) located predominantly in the right cerebral hemisphere. Monkeys would seem to process faces in a different manner to humans since they ap...

    journal_title:Behavioural brain research

    pub_type: 杂志文章

    doi:10.1016/0166-4328(88)90029-0

    authors: Perrett DI,Mistlin AJ,Chitty AJ,Smith PA,Potter DD,Broennimann R,Harries M

    更新日期:1988-08-01 00:00:00

  • Differential expression of mitogen-activated protein kinase signaling pathway in the hippocampus of rats exposed to chronic unpredictable stress.

    abstract::Much research has indicated that the mitogen-activated protein kinase (MAPK)-cAMP response element-binding protein (CREB) signal transduction pathway is involved in the pathophysiological mechanism of depression. But as to the question of which MAPKs are more relevant to stress effects, there is no definite answer. In...

    journal_title:Behavioural brain research

    pub_type: 杂志文章

    doi:10.1016/j.bbr.2009.06.036

    authors: Li H,Zhang L,Huang Q

    更新日期:2009-12-14 00:00:00

  • Neural correlates of liraglutide effects in persons at risk for Alzheimer's disease.

    abstract::Insulin resistance (IR) is a metabolic state preceding development of type 2 diabetes (DM2), cardiovascular disease, and neurodegenerative disorders, including Alzheimer's Disease (AD). Liraglutide, a glucagon-like peptide-1 (GLP) agonist, is an insulin-sensitizing agent with neuroprotective properties, as shown in an...

    journal_title:Behavioural brain research

    pub_type: 杂志文章,随机对照试验

    doi:10.1016/j.bbr.2018.08.006

    authors: Watson KT,Wroolie TE,Tong G,Foland-Ross LC,Frangou S,Singh M,McIntyre RS,Roat-Shumway S,Myoraku A,Reiss AL,Rasgon NL

    更新日期:2019-01-01 00:00:00

  • The CRF₁ receptor antagonist SSR125543 prevents stress-induced long-lasting sleep disturbances in a mouse model of PTSD: comparison with paroxetine and d-cycloserine.

    abstract::The selective CRF₁ (corticotropin releasing factor type 1) receptor antagonist SSR125543 has been previously shown to attenuate the long-term behavioral and electrophysiological effects produced by traumatic stress exposure in mice. Sleep disturbances are one of the most commonly reported symptoms by people with post-...

    journal_title:Behavioural brain research

    pub_type: 杂志文章

    doi:10.1016/j.bbr.2014.11.006

    authors: Philbert J,Beeské S,Belzung C,Griebel G

    更新日期:2015-02-15 00:00:00

  • Anxiolytic properties of N-acetylcysteine in mice.

    abstract::Anxiety disorders are highly prevalent and often result in poor quality of life. Available anxiolytics show significant adverse effects as well as partial efficacy in a sizable part of patients. Innovative treatments with more favorable risk-benefit ratio are sorely needed. A growing body of clinical data indicates th...

    journal_title:Behavioural brain research

    pub_type: 杂志文章

    doi:10.1016/j.bbr.2016.10.010

    authors: Santos P,Herrmann AP,Benvenutti R,Noetzold G,Giongo F,Gama CS,Piato AL,Elisabetsky E

    更新日期:2017-01-15 00:00:00

  • Individual susceptibility or resistance to posttraumatic stress disorder-like behaviours.

    abstract::The aim of this study was to explore the neurobiological background of individual susceptibility and resistance to the development of posttraumatic stress disorder (PTSD)-like behaviours. Rats were divided into susceptible, PTSD(+), and resistant, PTSD(-), groups based on freezing duration during exposure to aversive ...

    journal_title:Behavioural brain research

    pub_type: 杂志文章

    doi:10.1016/j.bbr.2020.112591

    authors: Skórzewska A,Lehner M,Wisłowska-Stanek A,Turzyńska D,Sobolewska A,Krząścik P,Szyndler J,Maciejak P,Chmielewska N,Kołosowska K,Płaźnik A

    更新日期:2020-05-27 00:00:00

  • Eye movements in the human fetus and newborn.

    abstract::The human oculomotor system becomes active long before birth. At about 16 weeks (post-menstrual age) the first slow changes of eye position can be observed with the aid of real time ultrasonography. At 18-20 weeks more rapid eye movements are detectable. There is a gradual decline in the percentage of time spent in ra...

    journal_title:Behavioural brain research

    pub_type: 杂志文章

    doi:10.1016/0166-4328(83)90157-2

    authors: Prechtl HF,Nijhuis JG

    更新日期:1983-10-01 00:00:00

  • Coordinated movement is influenced by prenatal light experience in bobwhite quail chicks (Colinus virginianus).

    abstract::Sensory-motor development begins early during embryogenesis and is influenced by sensory experience. Little is known about the prenatal factors that influence the development of motor coordination. Here we investigated whether and to what extent prenatal light experience can influence the development of motor coordina...

    journal_title:Behavioural brain research

    pub_type: 杂志文章

    doi:10.1016/j.bbr.2017.03.039

    authors: Belnap SC,Lickliter R

    更新日期:2017-06-01 00:00:00

  • Human avoidance and approach learning: evidence for overlapping neural systems and experiential avoidance modulation of avoidance neurocircuitry.

    abstract::Adaptive functioning is thought to reflect a balance between approach and avoidance neural systems with imbalances often producing pathological forms of avoidance. Yet little evidence is available in healthy adults demonstrating a balance between approach and avoidance neural systems and modulation in avoidance neuroc...

    journal_title:Behavioural brain research

    pub_type: 杂志文章

    doi:10.1016/j.bbr.2011.07.054

    authors: Schlund MW,Magee S,Hudgins CD

    更新日期:2011-12-01 00:00:00

  • Effect of forced locomotion on the rest-activity cycle of the cockroach.

    abstract::Many insects are known to exhibit clear circadian rest-activity rhythms. Attention has focussed more on active behaviors such as locomotion than on rest. I investigated the consequences of disturbances of the rest period on activity states of the cockroach Leucophea maderae. The 24-h rest-activity rhythm of individual...

    journal_title:Behavioural brain research

    pub_type: 杂志文章

    doi:10.1016/0166-4328(83)90180-8

    authors: Tobler I

    更新日期:1983-06-01 00:00:00

  • Intranigral transplants of immortalized GABAergic cells decrease the expression of kainic acid-induced seizures in the rat.

    abstract::Repeated systemic administration of low doses of kainic acid (KA) induces spontaneous convulsive seizures [Hellier JL, Patrylo PR, Buckmaster PS, Dudek FE. Recurrent spontaneous motor seizures after repeated low-dose systemic treatment with kainate: assessment of a rat model of temporal lobe epilepsy. Epilepsy Res 199...

    journal_title:Behavioural brain research

    pub_type: 杂志文章

    doi:10.1016/j.bbr.2006.03.025

    authors: Castillo CG,Mendoza S,Freed WJ,Giordano M

    更新日期:2006-07-15 00:00:00