Abstract:
:A better understanding of Alzheimer's disease (AD) and the development of disease modifying therapies are some of the biggest challenges of the 21st century. One of the core features of AD are amyloid plaques composed of amyloid-beta (Aβ) peptides. The first hypothesis proposed that cognitive deficits are linked to plaque-development and transgenic mice have been generated to study this link, thereby providing a good model to develop new therapeutic approaches. Since later it was recognised that in AD patients the cognitive deficit is rather correlated to soluble amyloid levels, consequently, a new hypothesis appeared associating the earliest amyloid toxicity to these soluble species. The purpose of this review is to give a summary of behavioural and cellular data obtained after soluble Aβ peptide administration into rodents' brain, thereby showing that this model is a valid tool to investigate AD pathology when no plaques are present. Additionally, this method offers an excellent, efficient model to test compounds which could act at such early stages of the disease.
journal_name
Behav Brain Resjournal_title
Behavioural brain researchauthors
Chambon C,Wegener N,Gravius A,Danysz Wdoi
10.1016/j.bbr.2011.08.024subject
Has Abstractpub_date
2011-12-01 00:00:00pages
623-41issue
2eissn
0166-4328issn
1872-7549pii
S0166-4328(11)00616-4journal_volume
225pub_type
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