Abstract:
:In the USA, the stimulant drug methylphenidate (MPH) is used to treat a large number (2 million or more per year) of children with Attention Deficit Hyperactivity Disorder (ADHD). Although the US FDA approved MPH in the 1960s, the pharmacokinetic (PK) properties of serum concentrations of MPH in children with ADHD were not described until the 1980s, and then in only a few cases. Recently, information from drug development programs have increased our knowledge about the serum PK and some pharmacodynamic (PD) characteristics of MPH in ADHD children, and studies based on positron emission tomograpy (PET) in adult volunteers have provided new knowledge about the PK properties of MPH at the primary site of action in the brain. We will review these two topics and use this new information to evaluate the mechanisms of action of MPH.
journal_name
Behav Brain Resjournal_title
Behavioural brain researchauthors
Swanson JM,Volkow NDdoi
10.1016/s0166-4328(01)00433-8subject
Has Abstractpub_date
2002-03-10 00:00:00pages
73-8issue
1-2eissn
0166-4328issn
1872-7549pii
S0166432801004338journal_volume
130pub_type
杂志文章,评审abstract::Simultaneous spatial-discrimination thresholds of 6 human subjects were measured at luminances between 0.2 and 2000 cd/m2. Subjects were tested on a forced-choice discrimination task which required them to distinguish between test and control stimuli of high contrast square-wave gratings with similar space-average lum...
journal_title:Behavioural brain research
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journal_title:Behavioural brain research
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journal_title:Behavioural brain research
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journal_title:Behavioural brain research
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journal_title:Behavioural brain research
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journal_title:Behavioural brain research
pub_type: 杂志文章
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journal_title:Behavioural brain research
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journal_title:Behavioural brain research
pub_type: 杂志文章
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journal_title:Behavioural brain research
pub_type: 杂志文章,评审
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journal_title:Behavioural brain research
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journal_title:Behavioural brain research
pub_type: 杂志文章
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更新日期:2011-09-12 00:00:00
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journal_title:Behavioural brain research
pub_type: 杂志文章
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journal_title:Behavioural brain research
pub_type: 杂志文章
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journal_title:Behavioural brain research
pub_type: 杂志文章
doi:10.1016/j.bbr.2012.08.048
更新日期:2013-01-01 00:00:00
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journal_title:Behavioural brain research
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journal_title:Behavioural brain research
pub_type: 杂志文章
doi:10.1016/0166-4328(82)90004-3
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journal_title:Behavioural brain research
pub_type: 杂志文章
doi:10.1016/j.bbr.2014.08.009
更新日期:2014-11-01 00:00:00
abstract::The association between morphine withdrawal and depressive-like symptoms is well documented, however, the role of dynorphin/κ opioid receptor system and the underlying neural substrates have not been fully understood. In the present study, we found that four weeks morphine abstinence after a chronic escalating morphin...
journal_title:Behavioural brain research
pub_type: 杂志文章
doi:10.1016/j.bbr.2015.05.053
更新日期:2015-09-15 00:00:00
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journal_title:Behavioural brain research
pub_type: 杂志文章
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journal_title:Behavioural brain research
pub_type: 杂志文章,评审
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journal_title:Behavioural brain research
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journal_title:Behavioural brain research
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journal_title:Behavioural brain research
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abstract::Prenatal restraint stress (PS) has been suggested as an attractive chronic model of anxiety. Here, we characterized the behavioral and autonomic responsivity to acute stress exposure in adult PS subjects. In Wistar rats, locomotor activity, as well as spontaneous behavior in an established animal model of anxiety, the...
journal_title:Behavioural brain research
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更新日期:2003-03-18 00:00:00
abstract::Dysfunctions of the serotonergic system have been suggested to be important in the neurobiology of schizophrenia. Patients with schizophrenia exhibit deficits in an operational measure of sensorimotor gating: prepulse inhibition (PPI) of startle. PPI is the normal reduction in the startle response caused by a low inte...
journal_title:Behavioural brain research
pub_type: 杂志文章
doi:10.1016/j.bbr.2017.01.053
更新日期:2017-05-15 00:00:00
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journal_title:Behavioural brain research
pub_type: 杂志文章
doi:10.1016/j.bbr.2012.05.026
更新日期:2012-08-01 00:00:00
abstract::After bilateral removal of the occipital lobe rabbits were studied in an enriched environment. At first their behaviour was severely impaired. After eight weeks the animals had learned to avoid obstacles, climb up ramps and jump from tables. It was shown that this recovery was due to the use of remaining visual struct...
journal_title:Behavioural brain research
pub_type: 杂志文章
doi:10.1016/0166-4328(85)90175-5
更新日期:1985-05-01 00:00:00
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journal_title:Behavioural brain research
pub_type: 杂志文章
doi:10.1016/j.bbr.2008.02.021
更新日期:2008-06-26 00:00:00
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journal_title:Behavioural brain research
pub_type: 杂志文章
doi:10.1016/j.bbr.2010.07.001
更新日期:2010-12-20 00:00:00
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journal_title:Behavioural brain research
pub_type: 杂志文章,评审
doi:10.1016/j.bbr.2014.08.053
更新日期:2014-12-15 00:00:00