Abstract：
:The effects of N-methyl-D-aspartate NMDA receptor antagonists on scopolamine-induced amnesia and on delay-interposed short-term memory performance were investigated using an 8-arm radial maze in rats. Scopolamine, a muscarinic antagonist, deteriorated the radial maze performance, while MK-801, an NMDA receptor channel blocker and CGS-19755, a competitive NMDA receptor antagonist, showed no obstruction to the spatial cognition in the non-delayed maze task. MK-801 (0.01-0.03 mg/kg, i.v.) and CGS-19755 (1-10 mg/kg, i.v.) significantly augmented scopolamine-induced deficit in the non-delayed maze task and impaired the short-term memory in the 5-min delay-interposed task. These results suggest that NMDA antagonists have a negative action on short-term memory and that the interaction between the NMDA and the central muscarinic system plays a role in modulating the cognitive function.
journal_name
Behav Brain Resjournal_title
Behavioural brain researchauthors
Li HB,Matsumoto K,Tohda M,Yamamoto M,Watanabe Hdoi
10.1016/s0166-4328(97)86075-5subject
Has Abstractpub_date
1997-02-01 00:00:00pages
225-8issue
1-2eissn
0166-4328issn
1872-7549pii
S0166-4328(97)86075-5journal_volume
83pub_type
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