Abstract：
:Autism is characterized by deficits in social interaction and social recognition. Although animal models of autism have demonstrated that model animals engage less in social interaction or attend less to conspecifics than control animals, no animal model has yet replicated the deficit in recognition of complex social interaction as is seen in humans with autism. Here, we show that marmosets discriminated between human actors who reciprocated in social exchanges and those who did not; however, marmosets with foetal exposure to valproic acid (VPA marmosets) did not. In the reciprocal condition, two actors exchanged food equally, while in the non-reciprocal condition, one actor (non-reciprocator) ended up with all food and the other actor with none. After observing these exchanges, the control marmosets avoided receiving food from the non-reciprocator in the non-reciprocal condition. However, the VPA marmosets did not show differential preferences in either condition, suggesting that the VPA marmosets did not discriminate between reciprocal and non-reciprocal interactions. These results indicate that normal marmosets can evaluate social interaction between third-parties, while the VPA marmosets are unable to recognize whether an individual is being reciprocal or not. This test battery can serve as a useful tool to qualify primate models of autism.
journal_name
Behav Brain Resjournal_title
Behavioural brain researchauthors
Yasue M,Nakagami A,Banno T,Nakagaki K,Ichinohe N,Kawai Ndoi
10.1016/j.bbr.2015.06.006subject
Has Abstractpub_date
2015-10-01 00:00:00pages
323-6eissn
0166-4328issn
1872-7549pii
S0166-4328(15)30035-8journal_volume
292pub_type
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pub_type： 杂志文章,评审
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pub_type： 杂志文章,评审
doi：10.1016/0166-4328(95)00129-8
更新日期：1995-11-01 00:00:00
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更新日期：2011-03-17 00:00:00
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更新日期：2007-01-25 00:00:00
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