Abstract：
:Prenatal restraint stress (PS) has been suggested as an attractive chronic model of anxiety. Here, we characterized the behavioral and autonomic responsivity to acute stress exposure in adult PS subjects. In Wistar rats, locomotor activity, as well as spontaneous behavior in an established animal model of anxiety, the elevated plus-maze, was unaffected by PS. However, the anxiogenic-like response normally seen on the plus-maze following a restraint stress was markedly potentiated in adult PS subjects, despite indistinguishable corticosterone responses. In addition, we assessed the tail skin temperature response to a mild social stressor, transient social mixing. The diazepam-sensitive, late phase of the temperature response was markedly potentiated in adult PS subjects. In summary, PS induces a persistent phenotype of increased behavioral and autonomic sensitivity to stress. This paradigm might serve as an attractive screening model for anti-anxiety compounds.
journal_name
Behav Brain Resjournal_title
Behavioural brain researchauthors
Rimondini R,Agren G,Börjesson S,Sommer W,Heilig Mdoi
10.1016/s0166-4328(02)00273-5subject
Has Abstractpub_date
2003-03-18 00:00:00pages
75-80issue
1-2eissn
0166-4328issn
1872-7549pii
S0166432802002735journal_volume
140pub_type
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