Older adults can learn to learn new motor skills.

abstract：:The present report describes the participation of nicotinic receptors (nAChRs) in controlling the excitability of local neuronal circuitries in the rat hippocampus and in the human cerebral cortex. The patch-clamp technique was used to record responses triggered by the non-selective agonist ACh and the alpha7-nAChR-se...

journal_title：Behavioural brain research

authors： Albuquerque EX,Pereira EF,Mike A,Eisenberg HM,Maelicke A,Alkondon M

更新日期：2000-08-01 00:00:00

abstract：:Sex differences in humans on virtual water maze navigation are well established when overall performance is measured, e.g., by the total time taken to find the hidden platform, total path length, or quadrant dwell time during probe trials. Currently, it is unknown whether males are better spatial learners than females...

journal_title：Behavioural brain research

authors： Woolley DG,Vermaercke B,Op de Beeck H,Wagemans J,Gantois I,D'Hooge R,Swinnen SP,Wenderoth N

更新日期：2010-04-02 00:00:00

abstract：:Identifying the mechanisms underlying the adverse effects of developmental neurotoxicants enables the design of therapies that can potentially reverse neurobehavioral deficits in adulthood. We administered chlorpyrifos (CPF), a model organophosphate pesticide to pregnant mice and identified visuospatial deficits in ad...

journal_title：Behavioural brain research

authors： Billauer-Haimovitch H,Slotkin TA,Dotan S,Langford R,Pinkas A,Yanai J

更新日期：2009-12-28 00:00:00

abstract：:There is evidence that early deprivation of vision prompts the use of body-based, egocentric spatial representations in congenitally blind individuals, whereas previous visual experience favors the use of object-based, allocentric representations (e.g. Pasqualotto A, Spiller MJ, Jansari AS, Proulx MJ. Visual experienc...

journal_title：Behavioural brain research

authors： Iachini T,Ruggiero G,Ruotolo F

更新日期：2014-10-15 00:00:00

abstract：:After ablation of the motor cortex contralateral to the preferred limb, rats were forced to use this limb in grasping food out of a horizontal tube by restraining the non-preferred foreleg with a bracelet. In a right-handed rat the motor behaviour is less impaired and the recovery is better after a left hemisphere les...

journal_title：Behavioural brain research

authors： Miklyaeva EI,Varlinskaya EI,Ioffe ME,Mats VN,Pokazanyeva LN,Kulikov MA

更新日期：1993-09-30 00:00:00

abstract：:Eight Spontaneously Hypertensive Rat (SHR), 8 Wistar-Kyoto (WKY) and 8 Wistar rats, all male, maintained at 80-85% of their free-feeding weight by controlled access to food, were exposed to a series of fixed time (FT) schedules whereby food pellets were regularly delivered regardless of the animals' behaviour. The FT ...

journal_title：Behavioural brain research

authors： Ibias J,Pellón R

更新日期：2011-09-30 00:00:00

abstract：:Immunohistological studies suggest abundant expression of Wfs1 protein in neurons and nerve fibers that lie in the vicinity of dopaminergic (DA-ergic) fibers and neurons. Therefore, we sought to characterize the function of DA-ergic system in Wfs1-deficient mice. In wild-type mice, amphetamine, an indirect agonist of ...

journal_title：Behavioural brain research

authors： Visnapuu T,Plaas M,Reimets R,Raud S,Terasmaa A,Kõks S,Sütt S,Luuk H,Hundahl CA,Eskla KL,Altpere A,Alttoa A,Harro J,Vasar E

更新日期：2013-05-01 00:00:00

abstract：:Rearing rats in isolation produces behavioural and neurochemical alterations similar to those observed in schizophrenia. Cannabinoids have also been implicated in inducing psychotic symptoms. In this study, we investigate the effect of the major psychoactive constituent of cannabis and partial cannabinoid CB(1) recept...

journal_title：Behavioural brain research

authors： Malone DT,Taylor DA

更新日期：2006-01-06 00:00:00

abstract：:The spatial learning ability of aged male and female Sprague-Dawley rats was assessed using the Morris water maze. To determine the influence of age-related visual deficits on performance levels, retinal morphologic measures were correlated with water maze performance for each rat. Rats were first trained on the water...

journal_title：Behavioural brain research

authors： Spencer RL,O'Steen WK,McEwen BS

更新日期：1995-06-01 00:00:00

abstract：:This study of leg flexion conditioning in dogs, which were trained under both avoidance and classical contingencies consecutively, confirmed and extended the results from the Wahlsten and Cole study (In Classical Conditioning II: Current Research and Theory, Appleton Century-Crofts, New York, 1972). Briefly, dogs were...

journal_title：Behavioural brain research

authors： Cassady JM

更新日期：1996-05-01 00:00:00

abstract：:Sex steroids exert potent effects on mood and mental state in the human. Our previous experimental findings in female rats suggest that these effects may be mediated, in part, by the action of estrogen on the 5-hydroxytryptamine2A receptor (5-HT(2A)R) and serotonin transporter (SERT) in brain. Here we review our recen...

journal_title：Behavioural brain research

authors： Fink G,Sumner B,Rosie R,Wilson H,McQueen J

更新日期：1999-11-01 00:00:00

abstract：:We examined the directionality of static and dynamic motor effects on cell discharge recorded during arm movements in motor cortex and area 5. Movements of 8 directions were performed by rhesus monkeys in a two-dimensional space ('movement task'). Static effects were determined using a static hold task in the same wor...

journal_title：Behavioural brain research

authors： Georgopoulos AP,Massey JT

更新日期：1985-11-01 00:00:00

abstract：:A neurochemical study of the transsynaptic interactions established between septal GABAergic interneurones and cholinergic septo-hippocampal neurones was conducted using mice. The effects of acute in vivo injections of either muscimol (20-500 ng/0.2 microliter), bicuculline (100 ng-1 micrograms/0.2 microliter) or sali...

journal_title：Behavioural brain research

authors： Durkin TP

更新日期：1992-09-28 00:00:00

abstract：:Morphine, commonly used to relieve the acute or chronic pain, has a high potential for addiction and exerts rewarding effects via a critical role for mesolimbic dopamine system. Studies suggest that addiction-related behavior is highly associated with inflammatory immune response, but the mechanisms are poorly underst...

journal_title：Behavioural brain research

authors： Chen JX,Huang KM,Liu M,Jiang JX,Liu JP,Zhang YX,Yang C,Xin WJ,Zhang XQ

更新日期：2017-09-29 00:00:00

abstract：:The effect of diazepam (1.0 mg/kg, i.p.) and buspirone (5.0 mg/kg, i.p.) on the burying behaviour latency (denoting actions on the animals' reactivity) and on the cumulative burying behaviour (directly reflecting the experimental anxiety levels), were analyzed in male-, intact females, at proestrus and metoestrus, and...

journal_title：Behavioural brain research

authors： Fernández-Guasti A,Picazo O

更新日期：1997-11-01 00:00:00

abstract：:Prepulse inhibition (PPI) of acoustic startle response is a valuable paradigm for sensorimotor gating processes. Previous research showed that acute administration of St. John's wort extract (500 mg/kg, p.o.) to rats caused significant disruption of PPI while elevating monoamines levels in some brain areas. The cause-...

journal_title：Behavioural brain research

authors： Tadros MG,Mohamed MR,Youssef AM,Sabry GM,Sabry NA,Khalifa AE

更新日期：2009-05-16 00:00:00

abstract：:Based on the results of independent studies the involvement of norepinephrine in REM sleep regulation was known. Isolated studies showed that the effect could be mediated through either one or more subtypes of adrenoceptors. Earlier we have reported that REM-OFF neurons continue firing during REM sleep deprivation and...

journal_title：Behavioural brain research

authors： Mallick BN,Singh S,Pal D

更新日期：2005-03-07 00:00:00

abstract：:Being cautious of unfamiliar conspecifics is adaptive because sick or aggressive conspecifics may jeopardize survival and well-being. However, prolonged or excessive caution, i.e. fear related to social situations, is maladaptive and may result in social anxiety disorder. Some anxiety disorders in humans are associate...

journal_title：Behavioural brain research

authors： Kolodziejczyk MH,Faesel N,Koch M,Fendt M

更新日期：2020-09-01 00:00:00

abstract：:One of the routine memory abilities impaired in amnesic patients with temporal-lobe damage is object-recognition memory--the ability to discriminate the familiarity of previously encountered objects. Reproducing this impairment has played a central role in animal models of amnesia during the past two decades, and unti...

journal_title：Behavioural brain research

authors： Mumby DG

更新日期：2001-12-14 00:00:00

abstract：:Interocular transfer of the habituation to diffuse photic stimuli was demonstrated to be almost complete in pigeons. Birds submitted to visual Wulst ablation or supraoptic commissure lesion performed in much the same way. In contrast, when the tectal and posterior commissures were lesioned, pigeons failed to show inte...

journal_title：Behavioural brain research

authors： Hamassaki DE,Britto LR

更新日期：1987-02-01 00:00:00

abstract：:In recent years muscarinic receptor agonists and cholinesterase inhibitors have been developed for the treatment of Alzheimer's disease. We have evaluated examples from both classes of compounds in rodent tests of reference and working memory, as well as tests that are sensitive to the side-effects of these compounds....

journal_title：Behavioural brain research

authors： Dawson GR,Iversen SD

更新日期：1993-11-30 00:00:00

abstract：:Exploration in a dark open field undergoes three progressive changes: (i) an initial phase of spending equal amounts of time in various zones of the arena changes to staying in the corners, and ultimately spending most of the time in one corner; (ii) travel paths are first circular and scattered all over the arena, bu...

journal_title：Behavioural brain research

authors： Avni R,Zadicario P,Eilam D

更新日期：2006-08-10 00:00:00

abstract：:Corticostriatal circuitry supports flexible reward learning and emotional behavior from the critical neurodevelopmental stage of adolescence through adulthood. It is still poorly understood how prescription drug exposure in adolescence may impact these outcomes in the long-term. We studied adolescent methylphenidate (...

journal_title：Behavioural brain research

authors： Izquierdo A,Pozos H,Torre Ade L,DeShields S,Cevallos J,Rodriguez J,Stolyarova A

更新日期：2016-07-15 00:00:00

abstract：:The present study examines how rats process object information in relation to other objects as well as to the global shape of an enclosure. Rats were introduced into either a round or a square arena with various arrays of freestanding portable corners (objects) that differed in spacing, orientation, and number. We fou...

journal_title：Behavioural brain research

authors： Yaski O,Eilam D

更新日期：2008-03-05 00:00:00

abstract：:Male rats outperform females in spatial tasks, such as the water maze (WM). Female rats are known to have higher basal serum corticosterone (CORT) levels and to manifest a more rapid and stronger CORT response to novel stressors. Sex differences in stress responses to the handling and forced swimming in the WM task mi...

journal_title：Behavioural brain research

authors： Beiko J,Lander R,Hampson E,Boon F,Cain DP

更新日期：2004-05-05 00:00:00

abstract：:Reactive oxygen species (ROS) and pro-inflammatory cytokines (PIC) are upregulated in post-traumatic stress disorder (PTSD). Histone deacetylase inhibitors (HDACi) modify genetic transcription and can diminish ROS and PIC escalation. They can also modulate levels of neurotransmitters such as catecholamines and seroton...

journal_title：Behavioural brain research

authors： Wilson CB,McLaughlin LD,Ebenezer PJ,Nair AR,Francis J

更新日期：2014-07-15 00:00:00

abstract：:It has been recently shown that Roman high- (RHA) and low- (RLA) avoidance rats show behavioural divergence in successive negative contrast (SNC) induced in one-way avoidance learning [Torres C, Cándido A, Escarabajal MD, de la Torre L, Maldonado A, Tobeña A, et al. Successive negative contrast effect in one-way avoid...

journal_title：Behavioural brain research

authors： Rosas JM,Callejas-Aguilera JE,Escarabajal M,Gómez MJ,de la Torre L,Agüero A,Tobeña A,Fernández-Teruel A,Torres C

更新日期：2007-12-11 00:00:00

abstract：:In order to study how the human brain acquires, records, and recalls the relationships that comprise the images of human memory, our laboratory initiated a research strategy more than two decades ago. The strategy began with the hypothesis that the complex patterns of human memory are constructed from numerous simple ...

journal_title：Behavioural brain research

authors： Alkon DL

更新日期：1995-01-23 00:00:00

abstract：:Neural plasticity is a term that encompasses a vast array of changes in the nervous system in response to a wide range of environmental disturbances. The conservative manner in which nervous systems produce behavior is explored in the act of scratching the head. Whether the scratching is done with the hind leg (flamin...

journal_title：Behavioural brain research

authors： Pellis SM

更新日期：2010-12-06 00:00:00

abstract：:The Morris water maze and the object displacement task are two popular tools used to investigate spatial learning and memory. Research has focused mainly on the acquisition of spatial tasks while little attention has been given to the retention phase. We examined the effects of different training procedures on retenti...

journal_title：Behavioural brain research

authors： Commins S,Cunningham L,Harvey D,Walsh D

更新日期：2003-02-17 00:00:00