Exploration in a dark open field: a shift from directional to positional progression and a proposed model of acquiring spatial information.


:Exploration in a dark open field undergoes three progressive changes: (i) an initial phase of spending equal amounts of time in various zones of the arena changes to staying in the corners, and ultimately spending most of the time in one corner; (ii) travel paths are first circular and scattered all over the arena, but gradually become anchored to one corner at which they start and end; (iii) traveled distance gradually decreases to that of the initial level seen in a lit open field. Altogether, rodents shift from a 'looping' exploration mechanism with feeble coupling with the environment, to 'home base' exploration which is firmly anchored to the environment. This shift also involves switching from momentary and sporadic to repeated returns to a specific, presumably familiar place, to which the animal navigates back from various other places. We suggest that this switching illustrates navigation first by directional and then by positional environmental cues, as hypothesized in the 'parallel map theory'. We also suggest that the transition from looping to home base behavior is part of a hierarchal construction of space representation via three modes of spatial information processing: (i) piloting--sequential processing, based on moving from one landmark to the next; (ii) orienting--parallel processing, based on moving from one point to the next, with the same starting and ending point; (iii) navigating--continuous processing, based on continuously updating the position in relation to several locations in the environment (map navigation).


Behav Brain Res


Avni R,Zadicario P,Eilam D




Has Abstract


2006-08-10 00:00:00














  • Parietal and frontal contributions to episodic encoding of location.

    abstract::Specific contributions of frontal and parietal regions to visuospatial encoding and attention remain controversial. This study used fMRI to examine associative encoding of sequentially-presented spatial cues and object stimuli. The cue preceded the centrally-displayed object by a jittered-delay-interval to better isol...

    journal_title:Behavioural brain research

    pub_type: 杂志文章


    authors: Hales JB,Brewer JB

    更新日期:2013-04-15 00:00:00

  • How do global and local geometries shape exploratory behavior in rats?

    abstract::The present study examines how rats process object information in relation to other objects as well as to the global shape of an enclosure. Rats were introduced into either a round or a square arena with various arrays of freestanding portable corners (objects) that differed in spacing, orientation, and number. We fou...

    journal_title:Behavioural brain research

    pub_type: 杂志文章


    authors: Yaski O,Eilam D

    更新日期:2008-03-05 00:00:00

  • Acute nicotine delays extinction of contextual fear in mice.

    abstract::Smoking is linked to post-traumatic stress disorder (PTSD) which suggests smoking is either a risk factor or an attempt at self-medication. The ability to reduce or extinguish fear-related memories may be altered in patients with PTSD and it is possible that nicotine modulates this. Although there are numerous studies...

    journal_title:Behavioural brain research

    pub_type: 杂志文章


    authors: Kutlu MG,Gould TJ

    更新日期:2014-04-15 00:00:00

  • Low doses of the NMDA receptor antagonists, MK-801, PEAQX, and ifenprodil, induces social facilitation in adolescent male rats.

    abstract::Adolescents display high levels of interactions with peers relative to other age groups, with these interactions further enhanced by ethanol under some circumstances. Understanding of the neural mechanisms underlying these high levels of social interactions is important given that alcohol use is initiated during adole...

    journal_title:Behavioural brain research

    pub_type: 杂志文章


    authors: Morales M,Varlinskaya EI,Spear LP

    更新日期:2013-08-01 00:00:00

  • Diabetes mellitus and Alzheimer's disease: GSK-3β as a potential link.

    abstract::It is well known that Alzheimer's disease (AD) is closely related to diabetes mellitus (DM), and AD is also regarded as Type 3 diabetes (T3D). However, the exact link between AD and DM is still unclear. Recently, more and more evidence has shown that glycogen synthase kinase-3β (GSK-3β) may be the potential link betwe...

    journal_title:Behavioural brain research

    pub_type: 杂志文章,评审


    authors: Zhang Y,Huang NQ,Yan F,Jin H,Zhou SY,Shi JS,Jin F

    更新日期:2018-02-26 00:00:00

  • Electrical stimulation of insular cortex elicits cardiac inhibition but insular lesions do not abolish conditioned bradycardia in rabbits.

    abstract::Conscious rabbits received electrical stimulation of insular and more posterior perirhinal cortex through chronically implanted electrodes. Active sites for cardiovascular responses were found in both anterior and posterior insular cortex as well as more posterior perirhinal regions. Although differential response top...

    journal_title:Behavioural brain research

    pub_type: 杂志文章


    authors: Powell DA,Buchanan S,Hernàndez L

    更新日期:1985-09-01 00:00:00

  • Differential outcomes aid the formation of categorical relationships between stimuli.

    abstract::The differential outcome effect is when learning is enhanced through the application of different outcomes to different conditions of a task. Here we explore whether one difference in learning with differential outcomes is an enhanced categorisation of objects. We demonstrate that participants learning conditional dis...

    journal_title:Behavioural brain research

    pub_type: 杂志文章


    authors: Easton A,Child S,Lopez-Crespo G

    更新日期:2011-09-12 00:00:00

  • Forebrain noradrenaline and oral self-administration of ethanol by rats.

    abstract::The effects of 6-hydroxydopamine-induced depletion of forebrain noradrenaline (NA) on oral intake of ethanol were studied in male Wistar rats. Prior depletion of NA produced a smaller and significantly less variable intake of a concentrated solution of ethanol than that of control rats, and this effect was not accompa...

    journal_title:Behavioural brain research

    pub_type: 杂志文章


    authors: Corcoran ME,Lewis J,Fibiger HC

    更新日期:1983-04-01 00:00:00

  • Voluntary exercise reduces plasma cortisol levels and improves transitory memory impairment in young and aged Octodon degus.

    abstract::Sleep deprivation (SD) has been reported to induce transient cognitive impairment in functional domains commonly affected in dementia, including memory. Indeed, sleep disturbance has been proposed as an early marker for Alzheimer's disease (AD). SD emulates many aging-related modifications, including important memory ...

    journal_title:Behavioural brain research

    pub_type: 杂志文章


    authors: Estrada C,Cuenca L,Cano-Fernandez L,Gil-Martinez AL,Sanchez-Rodrigo C,González-Cuello AM,Fernandez-Villalba E,Herrero MT

    更新日期:2019-11-05 00:00:00

  • Gender modulates the development of theta event related oscillations in adolescents and young adults.

    abstract::The developmental trajectories of theta band (4-7 Hz) event-related oscillations (EROs), a key neurophysiological constituent of the P3 response, were assessed in 2170 adolescents and young adults ages 12 to 25. The theta EROs occurring in the P3 response, important indicators of neurocognitive function, were elicited...

    journal_title:Behavioural brain research

    pub_type: 杂志文章


    authors: Chorlian DB,Rangaswamy M,Manz N,Kamarajan C,Pandey AK,Edenberg H,Kuperman S,Porjesz B

    更新日期:2015-10-01 00:00:00

  • The effects of hippocampal aspiration lesions on conditioning to the CS and to a background stimulus in trace conditioned suppression.

    abstract::Rats with hippocampal aspiration lesions or cortical control lesions were compared to sham operated controls in a trace conditioned suppression task, in which a long-lasting background stimulus played the role of more conventional contextual cues. In all three surgical treatment groups, conditioning to the explicit co...

    journal_title:Behavioural brain research

    pub_type: 杂志文章


    authors: Rawlins JN,Tanner J

    更新日期:1998-03-01 00:00:00

  • Postural performance in decerebrated rabbit.

    abstract::It is known that animals decerebrated at the premammillary level are capable of standing and walking without losing balance, in contrast to postmammillary ones which do not exhibit such behavior. The main goals of the present study were, first, to characterize the postural performance in premammillary rabbits, and, se...

    journal_title:Behavioural brain research

    pub_type: 杂志文章


    authors: Musienko PE,Zelenin PV,Lyalka VF,Orlovsky GN,Deliagina TG

    更新日期:2008-06-26 00:00:00

  • Contribution of GABAA receptor subunits to attention and social behavior.

    abstract:INTRODUCTION:GABA dysfunction is associated with a number of psychiatric conditions including schizophrenia, autism and depression. Blocking cortical GABAA receptors in rodents causes behavioral deficits, including impaired attention and sociability, that are consistent with the symptoms of these conditions. The subuni...

    journal_title:Behavioural brain research

    pub_type: 杂志文章


    authors: Paine TA,Chang S,Poyle R

    更新日期:2020-01-27 00:00:00

  • Training-stage related neuronal plasticity in limbic thalamus and cingulate cortex during learning: a possible key to mnemonic retrieval.

    abstract::This study is part of an ongoing project concerned with the analysis of the neural substrates of discriminative avoidance learning in rabbits. Multi-unit activity was recorded in 5 anterior and lateral thalamic nuclei and in 4 layers of 2 posterior cingulate cortical areas (29c/d and 29b) during learning. The rabbits ...

    journal_title:Behavioural brain research

    pub_type: 杂志文章


    authors: Gabriel M,Vogt BA,Kubota Y,Poremba A,Kang E

    更新日期:1991-12-20 00:00:00

  • Sex-specific impairment and recovery of spatial learning following the end of chronic unpredictable restraint stress: potential relevance of limbic GAD.

    abstract::Chronic restraint stress alters hippocampal-dependent spatial learning and memory in a sex-dependent manner, impairing spatial performance in male rats and leaving intact or facilitating performance in female rats. Moreover, these stress-induced spatial memory deficits improve following post-stress recovery in males. ...

    journal_title:Behavioural brain research

    pub_type: 杂志文章


    authors: Ortiz JB,Taylor SB,Hoffman AN,Campbell AN,Lucas LR,Conrad CD

    更新日期:2015-04-01 00:00:00

  • A novel highly selective 5-HT6 receptor antagonist attenuates ethanol and nicotine seeking but does not affect inhibitory response control in Wistar rats.

    abstract::Recent studies suggest a potential role for 5-hydroxytryptamine(6) (5-HT(6)) receptors in the regulation of addictive behavior. In the present study, our aim was to investigate whether the novel highly selective 5-HT(6) receptor antagonist compound (CMP) 42 affected nicotine and ethanol seeking behavior in Wistar rats...

    journal_title:Behavioural brain research

    pub_type: 杂志文章


    authors: de Bruin NMWJ,McCreary AC,van Loevezijn A,de Vries TJ,Venhorst J,van Drimmelen M,Kruse CG

    更新日期:2013-01-01 00:00:00

  • Subtle gait abnormalities in Nedd4 heterozygous mice.

    abstract::Nedd4 is a widely expressed ubiquitin ligase that is necessary for normal neuronal development and function. However, largely due to the lethality of Nedd4 homozygous knockout mice, little is known about the physiological roles of Nedd4 in the adult brain. In this study we used Nedd4 heterozygous mice, which are viabl...

    journal_title:Behavioural brain research

    pub_type: 杂志文章


    authors: Camera D,Boase NA,Kumar S,Pow DV,Poronnik P

    更新日期:2014-03-01 00:00:00

  • Seemingly paradoxical jumping in cataleptic haloperidol-treated rats is triggered by postural instability.

    abstract::Paradoxically, animals exhibiting haloperidol-induced cataleptic immobility can be induced to leap vigorously, by pushing them forward from behind. It is shown here that such jumping can also be produced by placing them on a board and tilting it tail-end upward until about 50 degrees above horizontal. In both situatio...

    journal_title:Behavioural brain research

    pub_type: 杂志文章


    authors: Morrissey TK,Pellis SM,Pellis VC,Teitelbaum P

    更新日期:1989-12-01 00:00:00

  • Novelty-induced conditioned place preference, sucrose preference, and elevated plus maze behavior in adult rats after repeated exposure to methylphenidate during the preweanling period.

    abstract::Early treatment with methylphenidate has a persistent effect on the affective (i.e., anxiety- and depressive-like) behaviors of adult rats and mice. Interestingly, age at methylphenidate exposure appears to be a critical determinant influencing the expression of affective behaviors. In the present study, we exposed ra...

    journal_title:Behavioural brain research

    pub_type: 杂志文章


    authors: Crawford CA,Der-Ghazarian T,Britt CE,Varela FA,Kozanian OO

    更新日期:2013-06-01 00:00:00

  • Neural correlates of the interactive relationship between memory deficits and depressive symptoms in nondemented elderly: resting fMRI study.

    abstract::Prospective studies have shown an association between depressive symptoms and cognitive impairment among older adults. However, the neural correlates of this relationship are poorly understood. Our aim was to examine whether interactive effects of memory deficits and depressive symptoms are present in the memory-assoc...

    journal_title:Behavioural brain research

    pub_type: 杂志文章


    authors: Goveas J,Xie C,Wu Z,Douglas Ward B,Li W,Franczak MB,Jones JL,Antuono PG,Yang Z,Li SJ

    更新日期:2011-06-01 00:00:00

  • Advances in the behavioural testing and network imaging of rodent recognition memory.

    abstract::Research into object recognition memory has been galvanised by the introduction of spontaneous preference tests for rodents. The standard task, however, contains a number of inherent shortcomings that reduce its power. Particular issues include the problem that individual trials are time consuming, so limiting the tot...

    journal_title:Behavioural brain research

    pub_type: 杂志文章,评审


    authors: Kinnavane L,Albasser MM,Aggleton JP

    更新日期:2015-05-15 00:00:00

  • Deficit in emotional learning in neurotrimin knockout mice.

    abstract::Neurotrimin (Ntm) belongs to the IgLON family of cell adhesion molecules with Lsamp, Obcam and kilon that regulate the outgrowth of neurites mostly by forming heterodimers. IgLONs have been associated with psychiatric disorders, intelligence, body weight, heart disease and tumours. This study provides an initial behav...

    journal_title:Behavioural brain research

    pub_type: 杂志文章


    authors: Mazitov T,Bregin A,Philips MA,Innos J,Vasar E

    更新日期:2017-01-15 00:00:00

  • Stress-induced changes in c-Fos and corticotropin releasing hormone immunoreactivity in the amygdala of the spontaneously hypertensive rat.

    abstract::The present study was undertaken to test the hypothesis that dysregulation of the amygdala contributes to the exaggerated autonomic response to stress in an animal model of essential hypertension. Spontaneously hypertensive (SHR) and normotensive Wistar male rats were chronically instrumented and exposed to 20 min of ...

    journal_title:Behavioural brain research

    pub_type: 杂志文章


    authors: Porter K,Hayward LF

    更新日期:2011-01-20 00:00:00

  • Dietary zinc supplementation during pregnancy prevents spatial and object recognition memory impairments caused by early prenatal ethanol exposure.

    abstract::Alcohol-induced zinc (Zn) deficiency is one of the mechanisms proposed as a cause of ethanol teratogenicity. Subcutaneous Zn treatment with ethanol in early pregnancy has been shown to prevent birth abnormalities and memory impairments in mice. This study examined whether dietary Zn supplementation throughout pregnanc...

    journal_title:Behavioural brain research

    pub_type: 杂志文章


    authors: Summers BL,Henry CM,Rofe AM,Coyle P

    更新日期:2008-01-25 00:00:00

  • Missense mutation of the reticulon-4 receptor alters spatial memory and social interaction in mice.

    abstract::The reticulon-4 receptor, encoded by RTN4R, limits axonal sprouting and neural plasticity by inhibiting the outgrowth of neurites. Human association studies have implicated mutations in RTN4R in the development of schizophrenia, including the identification of several rare nonconservative missense mutations of RTN4R i...

    journal_title:Behavioural brain research

    pub_type: 杂志文章


    authors: Lazar NL,Singh S,Paton T,Clapcote SJ,Gondo Y,Fukumura R,Roder JC,Cain DP

    更新日期:2011-10-10 00:00:00

  • Sensorimotor recovery from cortical injury is accompanied by changes on norepinephrine and serotonin levels in the dentate gyrus and pons.

    abstract::Monoamines such as norepinephrine (NE) and serotonin (5-HT) have shown to play an important role in motor recovery after brain injury. The effects elicited by these neurotransmitters have been reported as distal from the area directly affected. Remote changes may take place over minutes to weeks and play an important ...

    journal_title:Behavioural brain research

    pub_type: 杂志文章


    authors: Ramos-Languren LE,González-Piña R,Montes S,Chávez-García N,Ávila-Luna A,Barón-Flores V,Ríos C

    更新日期:2016-01-15 00:00:00

  • Electrophysiological, biochemical, neurohormonal and behavioural studies with WAY-100635, a potent, selective and silent 5-HT1A receptor antagonist.

    abstract::Although considerable progress has been made in characterising the 5-HT1A receptor using agonists, partial agonists or non-selective antagonists, further studies of 5-HT1A receptor function have been hindered by the lack of highly selective antagonists. The term 'silent' antagonist has been used for such compounds in ...

    journal_title:Behavioural brain research

    pub_type: 杂志文章


    authors: Fletcher A,Forster EA,Bill DJ,Brown G,Cliffe IA,Hartley JE,Jones DE,McLenachan A,Stanhope KJ,Critchley DJ,Childs KJ,Middlefell VC,Lanfumey L,Corradetti R,Laporte AM,Gozlan H,Hamon M,Dourish CT

    更新日期:1996-01-01 00:00:00

  • Neonatal exposure to whole body ionizing radiation induces adult neurobehavioural defects: Critical period, dose--response effects and strain and sex comparison.

    abstract::Development of the brain includes periods which can be critical for its normal maturation. The present study investigates specifically vulnerable peri-/postnatal periods in mice which are essential for understanding the etiology behind radiation induced neurotoxicity and functional defects, including evaluation of neu...

    journal_title:Behavioural brain research

    pub_type: 杂志文章


    authors: Eriksson P,Buratovic S,Fredriksson A,Stenerlöw B,Sundell-Bergman S

    更新日期:2016-05-01 00:00:00

  • Functional aspects of the involvement of the hippocampus in behavior and memory functions.

    abstract::In order to outline the involvement of the hippocampus in behavior and memory functions the results of grafting experiments in the hippocampal formation are presented in addition to former lesion and stimulation studies. Grafts of fetal hippocampal tissue were found to induce short-term beneficial effects on learning ...

    journal_title:Behavioural brain research

    pub_type: 杂志文章,评审


    authors: Sprick U

    更新日期:1995-01-23 00:00:00

  • Prefrontal cortex lesions and scopolamine impair attention performance of C57BL/6 mice in a novel 2-choice visual discrimination task.

    abstract::Sustained attention is defined as the ability or capacity to remain focused on the occurrence of rare events over long periods of time. We describe here the development of a novel, operant-based attention task that can be learned by mice in 8-10 days. Mice were trained on a 2-choice visual discrimination task in an op...

    journal_title:Behavioural brain research

    pub_type: 杂志文章


    authors: Dillon GM,Shelton D,McKinney AP,Caniga M,Marcus JN,Ferguson MT,Kornecook TJ,Dodart JC

    更新日期:2009-12-01 00:00:00