Abstract：
:Huntington's disease (HD) is an autosomal dominant, neurodegenerative disorder with a characteristic triad of cognitive, affective and motor symptoms. Transgenic HD mice show excellent construct and face validity for many of these symptoms, however the decline in some facets of every day activity in humans is difficult to model. One approach is the assessment of species-relevant behaviors. Here we described three ethologically appropriate tests in the mouse-olfactory sensitivity, nest-building and sexually-motivated vocalizations. In R6/1 HD mice, olfactory and nest-building tests were sensitive to early dysfunctions induced by the HD mutation. Male vocalization testing revealed a late-stage sexual disinterest in R6/1 HD mice compared to WT littermates. We show that essential, species-relevant functions are disrupted by the HD mutation. The development of integrative behavioral assays which more closely model 'activities of daily living' (ADL) will facilitate the testing of novel therapeutic interventions in animal models as well as their clinical translation.
journal_name
Behav Brain Resjournal_title
Behavioural brain researchauthors
Mo C,Renoir T,Hannan AJdoi
10.1016/j.bbr.2014.04.003subject
Has Abstractpub_date
2015-01-01 00:00:00pages
17-27eissn
0166-4328issn
1872-7549pii
S0166-4328(14)00221-6journal_volume
276pub_type
杂志文章abstract：:Corticostriatal circuitry supports flexible reward learning and emotional behavior from the critical neurodevelopmental stage of adolescence through adulthood. It is still poorly understood how prescription drug exposure in adolescence may impact these outcomes in the long-term. We studied adolescent methylphenidate (...
journal_title：Behavioural brain research
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abstract：:Increasing evidence suggests that a brain-gut-microbiome axis exists, which has the potential to play a major role in modulating behaviour. However, the role of this axis in cognition remains relatively unexplored. Probiotics, which are commensal bacteria offering potential health benefit, have been shown to decrease ...
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abstract：:Zebrafish are increasingly being used in behavioral neuroscience, neuropsychopharmacology and neurotoxicology. Recently, behavioral screens used to model anxiety in rodents were adapted to this species, and novel models which tap on zebrafish behavioral ecology have emerged. However, model building is an arduous task ...
journal_title：Behavioural brain research
pub_type： 杂志文章,评审
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journal_title：Behavioural brain research
pub_type： 杂志文章
doi：10.1016/j.bbr.2013.02.031
更新日期：2013-06-01 00:00:00
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journal_title：Behavioural brain research
pub_type： 杂志文章
doi：10.1016/j.bbr.2007.04.006
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journal_title：Behavioural brain research
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journal_title：Behavioural brain research
pub_type： 杂志文章,评审
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abstract：:The purpose of this study was to develop a model of unilateral cervical (C4-C5) spinal cord contusion injury in the rat and to characterize the functional and histological consequences following three injury levels using a new weight-drop spinal cord injury device. We evaluated forepaw/forelimb and hindlimb functions ...
journal_title：Behavioural brain research
pub_type： 杂志文章
doi：10.1016/s0166-4328(00)00328-4
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journal_title：Behavioural brain research
pub_type： 杂志文章
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journal_title：Behavioural brain research
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doi：10.1016/j.bbr.2013.07.015
更新日期：2013-09-15 00:00:00
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journal_title：Behavioural brain research
pub_type： 杂志文章
doi：10.1016/s0166-4328(99)00023-6
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journal_title：Behavioural brain research
pub_type： 杂志文章
doi：10.1016/0166-4328(94)00182-f
更新日期：1995-09-01 00:00:00
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journal_title：Behavioural brain research
pub_type： 杂志文章
doi：10.1016/s0166-4328(89)80111-1
更新日期：1989-11-01 00:00:00
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journal_title：Behavioural brain research
pub_type： 杂志文章
doi：10.1016/j.bbr.2016.05.023
更新日期：2016-09-15 00:00:00
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journal_title：Behavioural brain research
pub_type： 杂志文章
doi：10.1016/j.bbr.2019.01.015
更新日期：2019-04-19 00:00:00
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journal_title：Behavioural brain research
pub_type： 杂志文章
doi：10.1016/s0166-4328(01)00449-1
更新日期：2002-08-21 00:00:00
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journal_title：Behavioural brain research
pub_type： 杂志文章
doi：10.1016/j.bbr.2016.05.041
更新日期：2016-09-15 00:00:00
abstract：:Regional cerebral blood flow (rCBF) was studied in a task, where a preparatory stimulus (S1) cued for an imperative second stimulus (S2) which was associated with a response. Two preparatory stimuli cued unequivocally each for one response. In contrast, a third preparatory stimulus cued for two response alternatives w...
journal_title：Behavioural brain research
pub_type： 杂志文章
doi：10.1016/j.bbr.2005.05.014
更新日期：2005-09-08 00:00:00
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journal_title：Behavioural brain research
pub_type： 杂志文章
doi：10.1016/s0166-4328(01)00369-2
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journal_title：Behavioural brain research
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journal_title：Behavioural brain research
pub_type： 杂志文章
doi：10.1016/0166-4328(80)90009-1
更新日期：1980-12-01 00:00:00
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pub_type： 杂志文章
doi：10.1016/s0166-4328(00)00377-6
更新日期：2001-06-01 00:00:00
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journal_title：Behavioural brain research
pub_type： 杂志文章
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更新日期：2016-10-15 00:00:00
abstract：:Non-human primates have become one of the most important model animals for the investigation of brain diseases because they share a wide-range of genetics and social similarities with human beings. Naturally-evoked depression models in macaques may offer a full spectrum of similarity to human depression states, but th...
journal_title：Behavioural brain research
pub_type： 杂志文章
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更新日期：2019-03-15 00:00:00
abstract：:There is evidence that early deprivation of vision prompts the use of body-based, egocentric spatial representations in congenitally blind individuals, whereas previous visual experience favors the use of object-based, allocentric representations (e.g. Pasqualotto A, Spiller MJ, Jansari AS, Proulx MJ. Visual experienc...
journal_title：Behavioural brain research
pub_type： 杂志文章
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更新日期：2014-10-15 00:00:00
abstract：:The mesolimbic dopaminergic system that projects from the ventral tegmental area (VTA) to the nucleus accumbens is critical for initiation of opioid reinforcement and reward-related effects of drugs of abuse. In the present study, the effects of reversible inactivation of VTA on acquisition and expression of morphine-...
journal_title：Behavioural brain research
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doi：10.1016/j.bbr.2008.11.030
更新日期：2009-03-17 00:00:00
abstract：:Although exposure to acute stress has been shown to reinstate extinguished responding for a wide variety of drugs, no studies have investigated stress-induced reinstatement in animals with a history of 3,4-methylenedioxymethamphetamine (MDMA; ecstasy) self-administration. Thus, rats were trained to press a lever for M...
journal_title：Behavioural brain research
pub_type： 杂志文章
doi：10.1016/j.bbr.2015.07.056
更新日期：2015-11-01 00:00:00
abstract：:Previous behavioral studies have manipulated nitric oxide (NO) production either by pharmacological inhibition of its synthetic enzyme, nitric oxide synthase (NOS), or by deletion of the genes that code for NOS. However manipulation of dietary intake of the NO precursor, L-arginine, has been understudied in regard to ...
journal_title：Behavioural brain research
pub_type： 杂志文章
doi：10.1016/j.bbr.2011.04.011
更新日期：2011-09-30 00:00:00
abstract：:Autism-affected individuals are characterized by lower plasma oxytocin and its ectoenzyme regulator CD38. Oxytocin, a hypothalamic hormone secreted upon the release of CD38, plays a role in social behavior and bonding. All-trans retinoic acid is a potent inducer of CD38 and can be used as a novel therapeutic strategy ...
journal_title：Behavioural brain research
pub_type： 杂志文章
doi：10.1016/j.bbr.2017.09.041
更新日期：2019-05-17 00:00:00
