Abstract:
:Severe temporal lobe epilepsy in humans is often associated with loss of neurons in the hippocampus and memory deficits. In Experiment 1, 60 min of continuous electrical stimulation of the perforant path sufficient to produce seizures resembling status epilepticus and loss of hilar and pyramidal cells in the hippocampus, produced a deficit in spatial mapping in the Morris water tank. In particular, the previously stimulated rats took longer and swam farther to find a hidden, but not a visually cued, platform, and, in contrast to the unstimulated control rats, were not disrupted by movement of the platform to a new location. In Experiment 2, a single injection of the non-competitive NMDA receptor antagonist, MK-801 (1.0 mg/kg), just prior to the perforant path stimulation reduced the seizures, hippocampal neuronal loss, and deficit in spatial mapping. These data suggest that temporal lobe seizures can induce deficits in spatial memory by selectively destroying neurons within the hippocampus, and that the mechanism by which this occurs involves the activation of NMDA receptors, and, perhaps, consequent excitotoxicity.
journal_name
Behav Brain Resjournal_title
Behavioural brain researchauthors
Kelsey JE,Sanderson KL,Frye CAdoi
10.1016/s0166-4328(99)00107-2subject
Has Abstractpub_date
2000-01-01 00:00:00pages
59-69issue
1-2eissn
0166-4328issn
1872-7549pii
S0166-4328(99)00107-2journal_volume
107pub_type
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