Abstract：
:In the present study we evaluated the involvement of nitric oxide (NO) system in the antidepressant-like effects of chronic lithium administration in the mouse forced swimming test (FST). Administration of lithium chloride (300 mg/L in drinking water for 21 days) had no effect on the immobility of mice in the FST, whereas 600 mg/L lithium caused a significant (P<0.001) decrease in the immobility time compared with control animals. Administration of the NO synthase inhibitor N(G)-nitro-L-arginine methyl ester (L-NAME, 10mg/kg, daily for a week, i.p.) had no significant effect on the immobility time of either control or lithium (300 mg/L)-treated mice, whereas acute administration of non-effective dose of L-NAME (30 mg/kg, i.p.) caused a robust decrease (P<0.01) in the immobility time of lithium (300 mg/L)-treated animals in the FST. Moreover, chronic administration of low dose of the NO precursor L-arginine (200 mg/kg, daily for a week, i.p.) prevented (P<0.001) the antidepressant-like effects of lithium treatment (600 mg/L) in the FST. Acute treatment with L-arginine (200 mg/kg, i.p.) increased (P<0.05) the immobility time of lithium (600 mg/L)-treated mice in the FST. Chronic lithium treatment (600 mg/L but not 300 mg/L) caused a significant (P<0.05) decrease in the serum NO(X) levels in mice compared with controls. Our data suggested that the NO system could be involved in the antidepressant-like effect of chronic lithium treatment in the FST.
journal_name
Behav Brain Resjournal_title
Behavioural brain researchauthors
Ghasemi M,Sadeghipour H,Poorheidari G,Dehpour ARdoi
10.1016/j.bbr.2008.12.032subject
Has Abstractpub_date
2009-06-08 00:00:00pages
76-82issue
1eissn
0166-4328issn
1872-7549pii
S0166-4328(09)00009-6journal_volume
200pub_type
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