Abstract：
:Using a rat model of adolescent social stress (SS, daily 1 h isolation and change of cage partner, 30-45 days of age), we have reported sex-specific effects on neuroendocrine function over the course of SS, and enduring effects of SS in females, and not males, on drug-related behaviour. Here, we investigated both the immediate and enduring impact of SS in adolescence on anxiety-like behaviour in the elevated plus maze (EPM) and determined the temporal pattern of corticosterone release after confinement to the open arm of the EPM. When tested as adolescents, SS decreased anxiety-like behaviour in females and had no effect in males. When tested as adults several weeks after the chronic stress, overall, SS tended to increase anxiety-like behaviour in both sexes. However, estrous cycle moderated the effect in females, in that reduced anxiety-like behaviour was observed for SS females in the estrous group. Confinement to the open arm of the EPM increased plasma corticosterone concentrations, which declined markedly upon return to home cage for all except adolescent control males for which corticosterone concentrations at 45 and 90 min were elevated compared other groups. Among controls, anxiety-like behaviour decreased in females and increased in males with age, and confinement to the open arm of the EPM led to a greater increase in corticosterone concentrations in adult males compared to adolescent males. In sum, modest effects of adolescent social stress were observable several weeks after the stress exposure, indicating that sex-specific developmental trajectories and vulnerability to anxiety may be shaped by experiences in adolescence.
journal_name
Behav Brain Resjournal_title
Behavioural brain researchauthors
McCormick CM,Smith C,Mathews IZdoi
10.1016/j.bbr.2007.09.005subject
Has Abstractpub_date
2008-03-05 00:00:00pages
228-38issue
2eissn
0166-4328issn
1872-7549pii
S0166-4328(07)00467-6journal_volume
187pub_type
杂志文章abstract：:Gender differences in spatial navigation have been widely reported in nocturnal rodent species. Here, for the first time we report gender differences in spatial learning and memory of Octodon degus, a long-lived diurnal hystricomorph rodent. In the present study, 16 months old male and female O. degus were tested in t...
journal_title：Behavioural brain research
pub_type： 杂志文章
doi：10.1016/j.bbr.2010.04.005
更新日期：2010-10-15 00:00:00
abstract：:Maternal-deprivation of rodent pups is a relevant model of extreme early-life stress that can be relevant to the understanding of long-term effects of war, migration, parental loss and displacement. Although even mild stress during infancy affects brain development and behavior, the current study focused on the effect...
journal_title：Behavioural brain research
pub_type： 杂志文章
doi：10.1016/j.bbr.2019.112025
更新日期：2019-10-17 00:00:00
abstract：:The present study assessed the behavioural sequalae of unilateral excitotoxic cortical lesions made either in the medial agranular cortex (AGm) or in the medial prefrontal cortex (mPFC) using a visual reaction time task. The task required animals to sustain a nose-poke in a central hole, until a brief light stimulus w...
journal_title：Behavioural brain research
pub_type： 杂志文章
doi：10.1016/s0166-4328(00)00147-9
更新日期：2000-06-15 00:00:00
abstract：:The concept of a rat-robot was initially introduced in 2002, bringing to the field, a novel area of research using modern research into neuroscience and robotics. This paper brings to the table, a study into the method best used for navigation systems in a rat-robot. Current research is epitomized by the use of reward...
journal_title：Behavioural brain research
pub_type： 杂志文章
doi：10.1016/j.bbr.2015.11.002
更新日期：2016-02-01 00:00:00
abstract：:Herein, we investigated the effect Salvia sahendica (S. sahenica) extract, an endemic plant of Iran on the improvement of learning and memory deficits in amyloid beta-(Aβ) injected rats. In order to test this hypothesis, we pretreated rats with S. sahendica 1 week prior to Aβ injection, then performed Morris water maz...
journal_title：Behavioural brain research
pub_type： 杂志文章
doi：10.1016/j.bbr.2012.11.026
更新日期：2013-03-15 00:00:00
abstract：:Autism-affected individuals are characterized by lower plasma oxytocin and its ectoenzyme regulator CD38. Oxytocin, a hypothalamic hormone secreted upon the release of CD38, plays a role in social behavior and bonding. All-trans retinoic acid is a potent inducer of CD38 and can be used as a novel therapeutic strategy ...
journal_title：Behavioural brain research
pub_type： 杂志文章
doi：10.1016/j.bbr.2017.09.041
更新日期：2019-05-17 00:00:00
abstract：:Catechol-O-methyltransferase, an enzyme involved in regulating brain catecholamine levels, has been implicated in anxiety, pain and/or stress responsivity. Elements of this putative association remain unclarified, notably whether: (a) COMT variation modulates responses to acute and/or chronic stress equally; (b) acute...
journal_title：Behavioural brain research
pub_type： 杂志文章
doi：10.1016/j.bbr.2011.12.014
更新日期：2012-03-17 00:00:00
abstract：:Our previous work suggests that pharmacological induction of oxidative stress causes anxiety-like behavior in rats. Interestingly, sleep deprivation is reported to cause oxidative damage in the brain and is also reported to be anxiogenic. Minimal mechanistic insights are available. In this study, using a behavioral an...
journal_title：Behavioural brain research
pub_type： 杂志文章
doi：10.1016/j.bbr.2011.05.010
更新日期：2011-10-31 00:00:00
abstract：:Functional recovery after an experimental stroke can be assessed by multiple behavioral tests, however, there is no consensus about which test to use in long-term stroke recovery studies or whether the tests are affected by stroke surgery, post-operative care or behavioral compensation due to repeated testing. This re...
journal_title：Behavioural brain research
pub_type： 杂志文章,评审
doi：10.1016/j.bbr.2017.07.039
更新日期：2018-10-15 00:00:00
abstract：:Cognitive-behavioral therapy (CBT), a first-line treatment for pediatric anxiety disorders, is based on principles of threat learning and extinction. However, CBT does not work sufficiently for up to 40% of clinically anxious youth. The neural and behavioral correlates of conditioned inhibition might provide promising...
journal_title：Behavioural brain research
pub_type： 杂志文章
doi：10.1016/j.bbr.2020.112994
更新日期：2021-02-05 00:00:00
abstract：:Neuroplasticity including long-term depression (LTD) has been implicated in both learning processes and addiction. LTD can be blocked by intravenous administration of the interference peptide Tat-GluA2(3Y) that prevents regulated endocytosis of the alpha-amino-3-hydroxy-5-methyl-isoxazole-4-propionic acid (AMPA) recep...
journal_title：Behavioural brain research
pub_type： 杂志文章
doi：10.1016/j.bbr.2012.05.026
更新日期：2012-08-01 00:00:00
abstract：:The ventral part of the anteromedial thalamic nucleus (AMv) is heavily targeted by the dorsal premammillary nucleus (PMd), which is the main hypothalamic site that is responsive to both predator and conspecific aggressor threats. This PMd-AMv pathway is likely involved in modulating memory processing, and previous fin...
journal_title：Behavioural brain research
pub_type： 杂志文章
doi：10.1016/j.bbr.2017.10.038
更新日期：2018-02-26 00:00:00
abstract：:Light can elicit both circadian and acute physiological responses in humans. In a dose response protocol men and women were exposed to illuminances ranging from 3 to 9100 lux for 6.5 h during the early biological night after they had been exposed to <3 lux for several hours. Light exerted an acute alerting response as...
journal_title：Behavioural brain research
pub_type： 临床试验,杂志文章
doi：10.1016/s0166-4328(00)00236-9
更新日期：2000-10-01 00:00:00
abstract：:Neuroimmune signalling underlies addiction and comorbid depression. Clinical observations indicate that infections and chronic lesions are more frequent in drug users and elevated inflammatory states are evident in cocaine dependents. Therefore, lipopolysaccharide (LPS) and inflammatory cytokines represent an importan...
journal_title：Behavioural brain research
pub_type： 杂志文章
doi：10.1016/j.bbr.2015.03.054
更新日期：2015-01-01 00:00:00
abstract：:Though accumulating literature implicates that cytokines are involved in the pathophysiology of mental disorders, the role of interleukin-6 (IL-6) in learning and memory functions remains unresolved. The present study was undertaken to investigate the effect of IL-6 on amygdala-dependent fear learning. Adult Wistar ra...
journal_title：Behavioural brain research
pub_type： 杂志文章
doi：10.1016/j.bbr.2014.08.052
更新日期：2014-12-15 00:00:00
abstract：:Carriers of premutation alleles (55-200 CGG repeats) of the fragile X mental retardation 1 (FMR1) gene are spared the major neurodevelopmental symptomatology of fragile X syndrome patients carrying a full mutation (>200 repeats). In a proportion of premutation carriers, the repeat expansion is associated with a specif...
journal_title：Behavioural brain research
pub_type： 杂志文章
doi：10.1016/j.bbr.2005.03.007
更新日期：2005-07-30 00:00:00
abstract：:In rats, exploratory activity and emotional reactivity towards novel stimuli reflect independent biological functions that are modulated differently by rearing experiences. Environmental enrichment is known to improve performance in exploratory tasks, while having inconsistent effects on emotionality. This study exami...
journal_title：Behavioural brain research
pub_type： 杂志文章
doi：10.1016/s0166-4328(00)00377-6
更新日期：2001-06-01 00:00:00
abstract：:Humans can perform, perceive, and imagine voluntary movement. Numerous investigations of these abilities have employed variants of goal-directed aiming tasks because the Fitts's law equation reliably captures the mathematical relationship between movement time (MT) and accuracy requirements. The emergence of Fitts's s...
journal_title：Behavioural brain research
pub_type： 杂志文章
doi：10.1016/j.bbr.2013.09.045
更新日期：2013-11-15 00:00:00
abstract：:To clarify the behavioral characteristics of rats neonatally treated with 6-hydroxydopamine (6-OHDA), their performance on 4 aversive learning tasks, 3 active (shuttle, one-way, and rearing) avoidance tasks and one passive (step-through) avoidance task, was examined. On days 2 and 4 after birth, each rat of F344/Du st...
journal_title：Behavioural brain research
pub_type： 杂志文章
doi：10.1016/0166-4328(95)00148-4
更新日期：1996-01-01 00:00:00
abstract：:Total hippocampal volume has previously been shown to correlate with performance on tests for verbal episodic memory. However, there are sparse evidence on how hippocampal subfield volumes are related to verbal episodic memory in healthy adults. The present study investigated the association between volumes of separat...
journal_title：Behavioural brain research
pub_type： 杂志文章
doi：10.1016/j.bbr.2018.06.008
更新日期：2018-10-01 00:00:00
abstract：:In order to study how the human brain acquires, records, and recalls the relationships that comprise the images of human memory, our laboratory initiated a research strategy more than two decades ago. The strategy began with the hypothesis that the complex patterns of human memory are constructed from numerous simple ...
journal_title：Behavioural brain research
pub_type： 杂志文章,评审
doi：10.1016/0166-4328(94)00142-3
更新日期：1995-01-23 00:00:00
abstract：:Dementia is one of the major medical challenges in the industrialized countries. An increasing number of demented patients shows ischemic brain lesions. One strategy to treat dementia could be the reinforcement of the multifarious neuroprotective actions of the endogenous cell modulator adenosine. This involves the mo...
journal_title：Behavioural brain research
pub_type： 杂志文章,评审
doi：10.1016/s0166-4328(97)86055-x
更新日期：1997-02-01 00:00:00
abstract：:Parkinson's disease (PD) is an age-dependent neurodegenerative disease that can be caused by a variety of factors. Growing evidence shows that prior to the motor phase of PD can express molecular or imaging markers. Many long non-coding RNAs (lncRNAs) have been identified in neurodegenerative disease. However, the bio...
journal_title：Behavioural brain research
pub_type： 杂志文章
doi：10.1016/j.bbr.2017.04.044
更新日期：2017-07-28 00:00:00
abstract：:We examined the long-term effects of administration of (S)-alpha-fluoromethylhistidine (FMH), a specific inhibitor of histidine decarboxylase, on the spontaneous locomotor activity, food intake and brain contents of histamine, catecholamines, serotonin and amino acids of ICR mice. The distance of ambulation and number...
journal_title：Behavioural brain research
pub_type： 杂志文章
doi：10.1016/0166-4328(96)00059-9
更新日期：1995-12-14 00:00:00
abstract：:Like human prehensile behavior, the pigeon's ingestive pecking response is elicited by visual stimuli conveying information about the location and size of the target. This information is used to generate localized ingestive pecks whose gapes are amplitude-scaled to seed size, prior to contact. We employed high-resolut...
journal_title：Behavioural brain research
pub_type： 杂志文章
doi：10.1016/s0166-4328(97)00121-6
更新日期：1998-03-01 00:00:00
abstract：:The ventral pallidum (VP) is a critical element of the mesocorticolimbic system that is inter-connected with motor and limbic structures and may be considered as an interface between motivational and effector neural signals. Dopamine is important in behavioral output of the VP, and dysfunctioning its dopamine quantity...
journal_title：Behavioural brain research
pub_type： 杂志文章
doi：10.1016/j.bbr.2011.10.041
更新日期：2012-02-01 00:00:00
abstract：:Ketamine, a noncompetitive N-methyl-d-aspartate (NMDA) receptor antagonist, produces quick and effective antidepressant results in depressed juvenile and adult individuals. The long-term consequences of using ketamine in juvenile populations are not well known, particularly as it affects vulnerability to drugs of abus...
journal_title：Behavioural brain research
pub_type： 杂志文章
doi：10.1016/j.bbr.2020.112626
更新日期：2020-07-01 00:00:00
abstract：:Among learning and memory processes, fear memories are crucial in some psychiatric disorders like post-traumatic stress disorder (PTSD). Accumulating evidence shows that the sigma-1 receptor (Sig-1R) has comprehensive involvement in cognitive impairment and neuroprotective effects. It has also been reported that BDNF ...
journal_title：Behavioural brain research
pub_type： 杂志文章
doi：10.1016/j.bbr.2016.05.056
更新日期：2016-09-15 00:00:00
abstract：:Animal models of anxiety have usually employed nocturnal species (e.g. rats and mice), and the tests used have been almost exclusively performed during the diurnal phase (lights on). Here, for the first time, we tested anxiety in a diurnal rodent, Octodon degus, according to its age (23 versus 40 months of age) and th...
journal_title：Behavioural brain research
pub_type： 杂志文章
doi：10.1016/j.bbr.2009.01.001
更新日期：2009-06-08 00:00:00
abstract：:Measurement of cardiac and respiratory activity during mental simulation of locomotion at increasing speed revealed a covariation of heart rate and pulmonary ventilation with the degree of imagined effort. The degree of vegetative activation of a subject mentally running at 12 km/h was comparable to that of a subject ...
journal_title：Behavioural brain research
pub_type： 杂志文章
doi：10.1016/s0166-4328(05)80033-6
更新日期：1991-01-31 00:00:00
