Abstract：
:The present study assessed the behavioural sequalae of unilateral excitotoxic cortical lesions made either in the medial agranular cortex (AGm) or in the medial prefrontal cortex (mPFC) using a visual reaction time task. The task required animals to sustain a nose-poke in a central hole, until a brief light stimulus was presented in either of two holes which were located on the same side of the box: this enabled performance on each side of the rat's body to be assessed independently. Lesions of the AGm impaired performance on the contralateral side, with rats biasing their responding to the nearer of the two response locations. Analysis of the deficit revealed that rats were able to discriminate between the two stimuli and suggested that AGm lesions disrupted the control of contralateral responding. Lesions of the mPFC produced similar response-related deficits, but these were more transient in nature. Neither AGm lesions nor mPFC lesions impaired performance on the ipsilateral side, consistent with the concept of an egocentrically coded deficit.
journal_name
Behav Brain Resjournal_title
Behavioural brain researchauthors
Brasted PJ,Dunnett SB,Robbins TWdoi
10.1016/s0166-4328(00)00147-9subject
Has Abstractpub_date
2000-06-15 00:00:00pages
139-51issue
1-2eissn
0166-4328issn
1872-7549pii
S0166432800001479journal_volume
111pub_type
杂志文章abstract：:The ventral pallidum (VP) is a critical element of the mesocorticolimbic system that is inter-connected with motor and limbic structures and may be considered as an interface between motivational and effector neural signals. Dopamine is important in behavioral output of the VP, and dysfunctioning its dopamine quantity...
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