Locomotor sites mapped with low current stimulation in intact and kainic acid damaged hypothalamus of anesthetized rats.

Abstract:

:To determine whether local neurons mediated the locomotor effects of electrical stimulation of the lateral hypothalamus, kainic acid injections (0.5-1.25 micrograms), intended to destroy neural somata as opposed to fibers of passage, were made unilaterally in the tuberal-posterior hypothalamus of 22 rats. The area of lesion and its contralateral homolog were mapped for locomotor stepping sites in Nembutal-anesthetized rats mounted in a stereotaxic apparatus such that locomotor stepping rotated a wheel. Stimulation (25 and 50 microA, 50 Hz, 0.5-ms cathodal pulses, 10-s trains) was delivered through 50-80 microns glass pipettes filled with 2 M saline. Contralateral to the lesion, locomotor stepping sites were common in the perifornical lateral and medial hypothalamus and less dense in the zona incerta. On the side of the kainic-acid lesion, locomotor sites were generally absent in the central part of the damaged area. If they did appear within the area of lesion, they tended to be near the border with intact tissue. In a few cases, locomotor stepping sites were found centrally located in the lesion amidst widespread loss of somata. In four rats, additional maps of anterior locomotor regions in the preoptic area ipsilateral to the lesion suggested that their descending fibers were largely spared by the kainic lesions. Local neurons appear to be major contributors to the locomotion elicited by electrical stimulation of the lateral hypothalamus, but fibers of passage may also participate.

journal_name

Behav Brain Res

authors

Sinnamon HM,Marciello M,Goerner DW

doi

10.1016/s0166-4328(05)80096-8

subject

Has Abstract

pub_date

1991-12-13 00:00:00

pages

49-61

issue

1

eissn

0166-4328

issn

1872-7549

pii

S0166-4328(05)80096-8

journal_volume

46

pub_type

杂志文章
  • Nefiracetam ameliorates learning deficits in older rabbits and may act via the hippocampus.

    abstract::Behavioral and neurobiological parallels between rabbits and humans in eyeblink classical conditioning (EBCC) make this paradigm potentially useful for preclinical and clinical trials. The known involvement of hippocampal pyramidal cells in EBCC in rabbits led us to evaluate the nootropic compound, nefiracetam. In Exp...

    journal_title:Behavioural brain research

    pub_type: 杂志文章

    doi:10.1016/s0166-4328(97)86065-2

    authors: Woodruff-Pak DS

    更新日期:1997-02-01 00:00:00

  • The dorsal periaqueductal gray modulates the increased fear-like behavior exhibited by experienced rats in the elevated plus-maze.

    abstract::Elevated plus-maze (EPM) experienced rats show reduced open arms exploration in a subsequent EPM exposure, expressing the increased open arms avoidance which is characteristic of anxiety/fear-like behavior. The midbrain dorsal periaqueductal gray (dPAG) is an important integrative area of the neuroaxis able to control...

    journal_title:Behavioural brain research

    pub_type: 杂志文章

    doi:10.1016/j.bbr.2009.09.001

    authors: Kincheski GC,Carobrez AP

    更新日期:2010-01-05 00:00:00

  • A role for the head-direction system in geometric learning.

    abstract::Several recent models of episodic memory have highlighted a potential contribution from the head-direction system; there is, however, surprisingly little known about the behavioural effects of selective lesions within the head-direction system. To address this issue, and determine what aspects of spatial memory are de...

    journal_title:Behavioural brain research

    pub_type: 杂志文章

    doi:10.1016/j.bbr.2011.05.033

    authors: Vann SD

    更新日期:2011-10-10 00:00:00

  • Effects of dopamine depletion from the caudate-putamen and nucleus accumbens septi on the acquisition and performance of a conditional discrimination task.

    abstract::Three experiments compared the effects of dopamine depletion from the caudate-putamen (CAUD; dorsal striatum) or nucleus accumbens septi (NAS; ventral striatum), or a systemically administered dopamine receptor antagonist (alpha-flupenthixol) on the acquisition and performance of a conditional discrimination task invo...

    journal_title:Behavioural brain research

    pub_type: 杂志文章

    doi:10.1016/0166-4328(90)90179-i

    authors: Robbins TW,Giardini V,Jones GH,Reading P,Sahakian BJ

    更新日期:1990-05-28 00:00:00

  • Lateral masking effects on contrast sensitivity in rats.

    abstract::Changes in target visibility may be produced by additional stimulus elements at adjacent locations. Such contextual effects may reflect lateral interactions of stimulus representations in early cortical areas. It has been reported that the organization of orientation preference found in primates and cats visual cortex...

    journal_title:Behavioural brain research

    pub_type: 杂志文章

    doi:10.1016/j.bbr.2017.07.046

    authors: Kurylo DD,Yeturo S,Lanza J,Bukhari F

    更新日期:2017-09-29 00:00:00

  • Studies on wakefulness-promoting effect of memantine in rats.

    abstract::We hypothesized that memantine, an anti-dementia drug, may be useful for the treatment of excessive daytime sleepiness. The effect of memantine on excessive sleepiness after 6 h sleep deprivation was studied in comparison with that of methylphenidate, and the involvement of the dopaminergic system in the wakefulness-p...

    journal_title:Behavioural brain research

    pub_type: 杂志文章

    doi:10.1016/j.bbr.2009.09.025

    authors: Ishida T,Obara Y,Kamei C

    更新日期:2010-01-20 00:00:00

  • Neuroimaging the temporal dynamics of human avoidance to sustained threat.

    abstract::Many forms of human psychopathology are characterized by sustained negative emotional responses to threat and chronic behavioral avoidance, implicating avoidance as a potential transdiagnostic factor. Evidence from both nonhuman neurophysiological and human neuroimaging studies suggests a distributed frontal-limbic-st...

    journal_title:Behavioural brain research

    pub_type: 杂志文章

    doi:10.1016/j.bbr.2013.09.042

    authors: Schlund MW,Hudgins CD,Magee S,Dymond S

    更新日期:2013-11-15 00:00:00

  • Effects of light stimulation of embryos on the use of position-specific and object-specific cues in binocular and monocular domestic chicks (Gallus gallus).

    abstract::Chicks hatched from eggs incubated in the dark (D-chicks) or from eggs exposed to light during the last 3 days before hatching (L-chicks) were trained on day 4 to peck at small cones for food reinforcement. The cones had different patterns (checked or striped) and were located in different positions (either on the lef...

    journal_title:Behavioural brain research

    pub_type: 杂志文章

    doi:10.1016/j.bbr.2005.03.024

    authors: Chiandetti C,Regolin L,Rogers LJ,Vallortigara G

    更新日期:2005-08-30 00:00:00

  • Continuous psychosocial stress stimulates BMP signaling in dorsal hippocampus concomitant with anxiety-like behavior associated with differential modulation of cell proliferation and neurogenesis.

    abstract::Bone morphogenetic protein (BMP) signaling in the hippocampus regulates psychiatric behaviors and hippocampal neurogenesis in non-stress conditions; however, stress-induced changes in hippocampal BMP signaling have not yet been reported. Therefore, we sought to examine whether psychosocial stress, which induces psychi...

    journal_title:Behavioural brain research

    pub_type: 杂志文章

    doi:10.1016/j.bbr.2020.112711

    authors: Mori M,Murata Y,Tsuchihashi M,Hanakita N,Terasaki F,Harada H,Kawanabe S,Terada K,Matsumoto T,Ohe K,Mine K,Enjoji M

    更新日期:2020-08-17 00:00:00

  • Injury during adolescence leads to sex-specific executive function deficits in adulthood in a pre-clinical model of mild traumatic brain injury.

    abstract::Adolescents are more likely than adults to develop chronic symptoms, such as impulsivity and difficulty concentrating, following a mild traumatic brain injury (mTBI) which may relate to disruption of pre-frontal cortex (PFC development). During adolescence the PFC is undergoing extensive remodelling, driving maturatio...

    journal_title:Behavioural brain research

    pub_type: 杂志文章

    doi:10.1016/j.bbr.2020.113067

    authors: Kaukas L,Holmes JL,Rahimi F,Collins-Praino L,Corrigan F

    更新日期:2020-12-14 00:00:00

  • Communal nesting, an early social enrichment, increases the adult anxiety-like response and shapes the role of social context in modulating the emotional behavior.

    abstract::Early experiences affect brain function and behavior at adulthood. Being reared in a communal nest (CN), consisting in a single nest where three mothers keep their pups together and share care-giving behavior from birth to weaning (postnatal day 25), provides a highly stimulating social environment to the developing p...

    journal_title:Behavioural brain research

    pub_type: 杂志文章

    doi:10.1016/j.bbr.2006.05.019

    authors: Branchi I,Alleva E

    更新日期:2006-09-25 00:00:00

  • Cognitive-motor interference during postural control indicates at-risk cerebellar profiles in females with the FMR1 premutation.

    abstract::Recent investigations report a higher risk of motor symptoms in females with the FMR1 premutation (PM-carriers) than has hitherto been appreciated. Here we examined basic sensorimotor and postural control under different sensory and attentional dual-task demands. Physiological performance and postural sway measures fr...

    journal_title:Behavioural brain research

    pub_type: 杂志文章

    doi:10.1016/j.bbr.2013.07.033

    authors: Kraan CM,Hocking DR,Georgiou-Karistianis N,Metcalfe SA,Archibald AD,Fielding J,Trollor J,Bradshaw JL,Cohen J,Cornish KM

    更新日期:2013-09-15 00:00:00

  • Lesion of the isthmo-optic nucleus impairs target selection for visually guided reaching.

    abstract::Neurons in the isthmo-optic nucleus (ION) of the avian midbrain receive input predominantly from the ipsilateral optic tectum and project to the contralateral retina. Therefore, lesion in the ION removes tectal efferent signals to the retina in birds. In the present study, we trained Japanese quail to reach a target s...

    journal_title:Behavioural brain research

    pub_type: 杂志文章

    doi:10.1016/j.bbr.2012.05.008

    authors: Uchiyama H,Ohno H,Kodama R

    更新日期:2012-08-01 00:00:00

  • Insular cortex lesions alter conditioned taste avoidance in rats differentially when using two methods of sucrose delivery.

    abstract::The insular gustatory cortex may be essential for the evaluation of saliency and representation of the incentive values of tastes. Gustatory cortex lesions should interfere with conditioned taste avoidance according to these factors, which depend on the conditioned taste avoidance protocol used. The present study was ...

    journal_title:Behavioural brain research

    pub_type: 杂志文章

    doi:10.1016/j.bbr.2003.12.011

    authors: Fresquet N,Angst MJ,Sandner G

    更新日期:2004-08-31 00:00:00

  • Impairments in spatial memory retention of GFAP-apoE4 female mice.

    abstract::The human apolipoprotein E isoforms, apoE2, apoE3, and apoE4, have differential effects on brain function. Compared to apoE3, apoE4 increases the risk of age-related cognitive decline in humans and female mice expressing apoE in neurons. Here, we show impaired spatial memory retention in female mice expressing apoE4 i...

    journal_title:Behavioural brain research

    pub_type: 杂志文章

    doi:10.1016/j.bbr.2006.10.024

    authors: van Meer P,Acevedo S,Raber J

    更新日期:2007-01-25 00:00:00

  • Revealing the cerebral regions and networks mediating vulnerability to depression: oxidative metabolism mapping of rat brain.

    abstract::The large variety of available animal models has revealed much on the neurobiology of depression, but each model appears as specific to a significant extent, and distinction between stress response, pathogenesis of depression and underlying vulnerability is difficult to make. Evidence from epidemiological studies sugg...

    journal_title:Behavioural brain research

    pub_type: 杂志文章

    doi:10.1016/j.bbr.2014.03.019

    authors: Harro J,Kanarik M,Kaart T,Matrov D,Kõiv K,Mällo T,Del Río J,Tordera RM,Ramirez MJ

    更新日期:2014-07-01 00:00:00

  • The inhibitory effect of norharman on morphine withdrawal syndrome in rats: comparison with ibogaine.

    abstract::Norharman (20 mg/kg, i.p.) and ibogaine (40 mg/kg, i.p.) significantly attenuated naloxone (4 mg/kg, i.p.)-precipitated withdrawal syndrome in morphine-dependent rats. Several withdrawal signs, such as teeth-chattering, chewing, penile licking and diarrhoea, were decreased by both norharman and ibogaine. In addition, ...

    journal_title:Behavioural brain research

    pub_type: 杂志文章

    doi:10.1016/0166-4328(94)90080-9

    authors: Cappendijk SL,Fekkes D,Dzoljic MR

    更新日期:1994-11-16 00:00:00

  • Neuroprotective effect of tanshinone IIA-incubated mesenchymal stem cells on Aβ25-35-induced neuroinflammation.

    abstract::Mesenchymal stem cell transplantation can regulate neuroinflammation and treat Alzheimer's disease (AD), but its effect is attenuated by in vitro expansion. To solve this problem, we used tanshinone IIA (TIIA)-incubated mesenchymal stem cells (MSCs) to treat neuroinflammation caused by amyloid β-protein (Aβ). Here, we...

    journal_title:Behavioural brain research

    pub_type: 杂志文章

    doi:10.1016/j.bbr.2019.03.001

    authors: Huang N,Li Y,Zhou Y,Zhou Y,Feng F,Shi S,Ba Z,Luo Y

    更新日期:2019-06-03 00:00:00

  • Simvastatin prevents morphine antinociceptive tolerance and withdrawal symptoms through antioxidative effect and nitric oxide pathway in mice.

    abstract::Oxidative stress and the nitric oxide (NO) pathway are involved in the development of opioid analgesic tolerance and dependence. Simvastatin modulates NO and oxidative stress, so the present study aimed to investigate its effect on the development and expression of morphine analgesic tolerance and withdrawal signs in ...

    journal_title:Behavioural brain research

    pub_type: 杂志文章

    doi:10.1016/j.bbr.2020.113104

    authors: Houshmand G,Pourasghar M,Shiran M,Arab Firozjae A,Goudarzi M,Manouchehr F,Shirzad S,Assadpour S,Nikbakht J,Ghorbanzadeh B

    更新日期:2021-01-05 00:00:00

  • Is repeated exposure to immobilization needed to induce adaptation of the hypothalamic-pituitary-adrenal axis? Influence of adrenal factors.

    abstract::We have previously observed that a single exposure to a severe stressor such as immobilization in wooden boards (IMO) resulted in a faster return of plasma corticosterone (and to a lesser extent of ACTH) to basal activity when the rats were exposed again to the same stressor. In addition, the effect enhanced with time...

    journal_title:Behavioural brain research

    pub_type: 杂志文章

    doi:10.1016/s0166-4328(01)00340-0

    authors: Dal-Zotto S,Martí O,Armario A

    更新日期:2002-02-01 00:00:00

  • Behavioral characteristics of rats predisposed to learned helplessness: reduced reward sensitivity, increased novelty seeking, and persistent fear memories.

    abstract::The congenitally helpless rat strain, which was selectively bred for increased susceptibility to learned helplessness, may model the predisposition to affective disorders, including depression and post-traumatic stress disorder. Other than the selected trait, the behavior of this strain is not well characterized. In t...

    journal_title:Behavioural brain research

    pub_type: 杂志文章

    doi:10.1016/j.bbr.2005.06.016

    authors: Shumake J,Barrett D,Gonzalez-Lima F

    更新日期:2005-11-07 00:00:00

  • Overpressure blast injury-induced oxidative stress and neuroinflammation response in rat frontal cortex and cerebellum.

    abstract:BACKGROUND & AIM:Overpressure blast-wave induced brain injury (OBI) and its long-term neurological outcome pose significant concerns for military personnel. Our aim is to investigate the mechanism of injury due to OBI. METHODS:Rats were divided into 3 groups: (1) Control, (2) OBI (exposed 30psi peak pressure, 2-2.5ms)...

    journal_title:Behavioural brain research

    pub_type: 杂志文章

    doi:10.1016/j.bbr.2017.04.025

    authors: Toklu HZ,Yang Z,Oktay S,Sakarya Y,Kirichenko N,Matheny MK,Muller-Delp J,Strang K,Scarpace PJ,Wang KKW,Tümer N

    更新日期:2018-03-15 00:00:00

  • Perinatal flutamide and mounting and lordosis behavior in adult female Wistar and Sprague-Dawley rats.

    abstract::The present study was designed to investigate the possible role of perinatal androgens acting via the androgen receptor, as opposed to the estrogen receptor, for the differentiation of adult mounting and lordosis behavior in female rats. Female Wistar (W) and Sprague-Dawley (SD) rats were exposed to the anti-androgen ...

    journal_title:Behavioural brain research

    pub_type: 杂志文章

    doi:10.1016/s0166-4328(05)80238-4

    authors: Brand T,Slob AK

    更新日期:1991-07-01 00:00:00

  • Noradrenergic and corticosteroid receptors regulate somatic and motivational symptoms of morphine withdrawal.

    abstract::Somatic and motivational symptoms accompanying opiate withdrawal are considered one of the major reasons for relapse to opiate-seeking and opiate-taking behaviors. These symptoms are accompanied by the activation of stress-related processes including hypothalamic-pituitary-adrenal axis activity and noradrenergic (NA) ...

    journal_title:Behavioural brain research

    pub_type: 杂志文章

    doi:10.1016/j.bbr.2018.11.041

    authors: Solecki WB,Kus N,Gralec K,Klasa A,Pradel K,Przewłocki R

    更新日期:2019-03-15 00:00:00

  • Anxiolytic properties of N-acetylcysteine in mice.

    abstract::Anxiety disorders are highly prevalent and often result in poor quality of life. Available anxiolytics show significant adverse effects as well as partial efficacy in a sizable part of patients. Innovative treatments with more favorable risk-benefit ratio are sorely needed. A growing body of clinical data indicates th...

    journal_title:Behavioural brain research

    pub_type: 杂志文章

    doi:10.1016/j.bbr.2016.10.010

    authors: Santos P,Herrmann AP,Benvenutti R,Noetzold G,Giongo F,Gama CS,Piato AL,Elisabetsky E

    更新日期:2017-01-15 00:00:00

  • Electrophysiological, biochemical, neurohormonal and behavioural studies with WAY-100635, a potent, selective and silent 5-HT1A receptor antagonist.

    abstract::Although considerable progress has been made in characterising the 5-HT1A receptor using agonists, partial agonists or non-selective antagonists, further studies of 5-HT1A receptor function have been hindered by the lack of highly selective antagonists. The term 'silent' antagonist has been used for such compounds in ...

    journal_title:Behavioural brain research

    pub_type: 杂志文章

    doi:10.1016/0166-4328(96)00118-0

    authors: Fletcher A,Forster EA,Bill DJ,Brown G,Cliffe IA,Hartley JE,Jones DE,McLenachan A,Stanhope KJ,Critchley DJ,Childs KJ,Middlefell VC,Lanfumey L,Corradetti R,Laporte AM,Gozlan H,Hamon M,Dourish CT

    更新日期:1996-01-01 00:00:00

  • Preservation of perceptual integration improves temporal stability of bimanual coordination in the elderly: an evidence of age-related brain plasticity.

    abstract::Despite the apparent age-related decline in perceptual-motor performance, recent studies suggest that the elderly people can improve their reaction time when relevant sensory information are available. However, little is known about which sensory information may improve motor behaviour itself. Using a synchronization ...

    journal_title:Behavioural brain research

    pub_type: 杂志文章

    doi:10.1016/j.bbr.2014.08.043

    authors: Blais M,Martin E,Albaret JM,Tallet J

    更新日期:2014-12-15 00:00:00

  • Enrichment-dependent differences in novelty exploration in rats can be explained by habituation.

    abstract::In rats, exploratory activity and emotional reactivity towards novel stimuli reflect independent biological functions that are modulated differently by rearing experiences. Environmental enrichment is known to improve performance in exploratory tasks, while having inconsistent effects on emotionality. This study exami...

    journal_title:Behavioural brain research

    pub_type: 杂志文章

    doi:10.1016/s0166-4328(00)00377-6

    authors: Zimmermann A,Stauffacher M,Langhans W,Würbel H

    更新日期:2001-06-01 00:00:00

  • Automated radial 8-arm maze: A voluntary and stress-free behavior test to assess spatial learning and memory in mice.

    abstract::The radial arm maze (RAM) is a common behavioral test to assess spatial working and reference memory in mice. However, conventional RAM experiments require a substantial degree of manual handling and animals are usually subjected to prolonged periods of food or water deprivation to achieve sufficient learning motivati...

    journal_title:Behavioural brain research

    pub_type: 杂志文章

    doi:10.1016/j.bbr.2019.112352

    authors: Mei J,Kohler J,Winter Y,Spies C,Endres M,Banneke S,Emmrich JV

    更新日期:2020-03-02 00:00:00

  • Social isolation in rats inhibits oxidative metabolism, decreases the content of mitochondrial K-Ras and activates mitochondrial hexokinase.

    abstract::Recent observations have suggested that Ras signaling includes combinations of extracellular-signal-regulated Ras activation at the plasma membrane and endomembranes, and translocation of Ras from the plasma membrane to intracellular compartments. In this study we have shown that social isolation of rat decreases the ...

    journal_title:Behavioural brain research

    pub_type: 杂志文章

    doi:10.1016/j.bbr.2009.07.009

    authors: Zhuravliova E,Barbakadze T,Zaalishvili E,Chipashvili M,Koshoridze N,Mikeladze D

    更新日期:2009-12-28 00:00:00