Abstract：
:Rats with lesions of the medial frontal, ventral frontal or posterior parietal cortex in adulthood were compared behaviorally and neuroanatomically in adulthood with rats with similar removals at 7 days of age. The neonatal lesions altered cortical morphogenesis, especially in the ventral frontal and parietal groups, in which there was a marked thinning of remaining cortex distal to the lesion site. Behavior was assessed on an extensive battery of sensorimotor and maze-learning tests. Although there was sparing of function on some tests, the overall result was very little sparing on sensorimotor tests and only partial sparing on tests of maze learning in the frontal groups. The parietal neonates showed sparing on only one sensorimotor task and, in addition, showed unexpected deficits on sensorimotor and maze-learning tasks that were not observed in the adult operates. The results suggest that there may be more localization of function in the infant cortex than is generally believed and that early cortical damage may produce different behavioral effects than similar damage in adulthood.
journal_name
Behav Brain Resjournal_title
Behavioural brain researchauthors
Kolb B,Whishaw IQdoi
10.1016/0166-4328(85)90005-1subject
Has Abstractpub_date
1985-09-01 00:00:00pages
25-43issue
1eissn
0166-4328issn
1872-7549pii
0166-4328(85)90005-1journal_volume
17pub_type
杂志文章abstract：:The present study was undertaken to test the hypothesis that dysregulation of the amygdala contributes to the exaggerated autonomic response to stress in an animal model of essential hypertension. Spontaneously hypertensive (SHR) and normotensive Wistar male rats were chronically instrumented and exposed to 20 min of ...
journal_title：Behavioural brain research
pub_type： 杂志文章
doi：10.1016/j.bbr.2010.08.036
更新日期：2011-01-20 00:00:00
abstract：:Cortical local field potentials (LFPs) are modulated in parallel with single neuron discharge, but the information they carry is often unclear. Multi-electrode recordings of both LFPs and single neuron activities were made in motor cortex as monkeys performed a delayed pointing task in which the probability of the mom...
journal_title：Behavioural brain research
pub_type： 杂志文章
doi：10.1016/j.bbr.2006.02.004
更新日期：2006-05-15 00:00:00
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journal_title：Behavioural brain research
pub_type： 杂志文章
doi：10.1016/s0166-4328(02)00085-2
更新日期：2003-02-17 00:00:00
abstract：:The negative impact of chemotherapy on cognitive function in cancer patients has gained increasing attention in the last decade. Whilst the short-term acute effects on cognition are expected following chemotherapy, the persistence of such impairments in the long-term is still in question. This is despite clinical evid...
journal_title：Behavioural brain research
pub_type： 杂志文章
doi：10.1016/j.bbr.2016.07.043
更新日期：2016-12-15 00:00:00
abstract：:In order to find out whether the inferior colliculus, in addition to its auditory decoding function, also has an auditory gating function in the sense that it treats self-produced sounds differently from external ones, we have explored the inferior colliculus and bordering tegmentum for neurones reacting differently t...
journal_title：Behavioural brain research
pub_type： 杂志文章
doi：10.1016/j.bbr.2003.09.008
更新日期：2004-05-05 00:00:00
abstract：:Administration of beta-phenylpyruvate at high concentrations reduces blood glucose levels and causes neurophysiological deterioration in insulin-deprived mice. We investigated whether beta-phenylpyruvate administration would cause long-term neurobehavioral and structural central neural damage in mice. Neonatal ICR mic...
journal_title：Behavioural brain research
pub_type： 杂志文章
doi：10.1016/s0166-4328(03)00075-5
更新日期：2003-07-14 00:00:00
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journal_title：Behavioural brain research
pub_type： 杂志文章
doi：10.1016/j.bbr.2014.04.027
更新日期：2014-08-01 00:00:00
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journal_title：Behavioural brain research
pub_type： 杂志文章
doi：10.1016/0166-4328(80)90043-1
更新日期：1980-02-01 00:00:00
abstract：:We recently reported that Pavlovian fear conditioning and hippocampal perforant-path long-term potentiation (LTP) are sexually dimorphic in rats. Males show greater contextual fear conditioning, which depends on the hippocampus, as well as greater hippocampal LTP. In order to examine the role of circulating gonadal ho...
journal_title：Behavioural brain research
pub_type： 杂志文章
doi：10.1016/s0166-4328(97)00115-0
更新日期：1998-04-01 00:00:00
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journal_title：Behavioural brain research
pub_type： 杂志文章
doi：10.1016/j.bbr.2015.02.037
更新日期：2015-06-01 00:00:00
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journal_title：Behavioural brain research
pub_type： 杂志文章
doi：10.1016/j.bbr.2021.113142
更新日期：2021-01-25 00:00:00
abstract：:Insulin resistance (IR) is a metabolic state preceding development of type 2 diabetes (DM2), cardiovascular disease, and neurodegenerative disorders, including Alzheimer's Disease (AD). Liraglutide, a glucagon-like peptide-1 (GLP) agonist, is an insulin-sensitizing agent with neuroprotective properties, as shown in an...
journal_title：Behavioural brain research
pub_type： 杂志文章,随机对照试验
doi：10.1016/j.bbr.2018.08.006
更新日期：2019-01-01 00:00:00
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journal_title：Behavioural brain research
pub_type： 杂志文章
doi：10.1016/j.bbr.2014.06.014
更新日期：2014-09-01 00:00:00
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journal_title：Behavioural brain research
pub_type： 杂志文章
doi：10.1016/j.bbr.2003.10.034
更新日期：2004-07-09 00:00:00
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journal_title：Behavioural brain research
pub_type： 杂志文章
doi：10.1016/0166-4328(88)90029-0
更新日期：1988-08-01 00:00:00
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journal_title：Behavioural brain research
pub_type： 杂志文章
doi：10.1016/j.bbr.2008.08.012
更新日期：2009-01-30 00:00:00
abstract：:Central administration of angiotensin IV (Ang IV) analogues attenuates scopolamine-induced amnesia. Ang IV mediates its effects by binding to a high affinity, binding site, AT(4) receptor, that has recently been identified as insulin regulated aminopeptidase (IRAP). The purpose of this study was to examine the effect ...
journal_title：Behavioural brain research
pub_type： 杂志文章
doi：10.1016/j.bbr.2004.02.012
更新日期：2004-09-23 00:00:00
abstract：:Bone morphogenetic protein (BMP) signaling in the hippocampus regulates psychiatric behaviors and hippocampal neurogenesis in non-stress conditions; however, stress-induced changes in hippocampal BMP signaling have not yet been reported. Therefore, we sought to examine whether psychosocial stress, which induces psychi...
journal_title：Behavioural brain research
pub_type： 杂志文章
doi：10.1016/j.bbr.2020.112711
更新日期：2020-08-17 00:00:00
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journal_title：Behavioural brain research
pub_type： 杂志文章,评审
doi：10.1016/0166-4328(94)00116-w
更新日期：1995-01-23 00:00:00
abstract：:Single unit activity was recorded from the ventral part of the lateral geniculate nucleus (vLGN) in rats anaesthetized with urethane. Most of the cells located laterally in the nucleus were excited by light. The studied vLGN neurones did not respond to electrical stimulation of the tail, but about half of them changed...
journal_title：Behavioural brain research
pub_type： 杂志文章
doi：10.1016/s0166-4328(05)80294-3
更新日期：1992-09-28 00:00:00
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journal_title：Behavioural brain research
pub_type： 杂志文章
doi：10.1016/j.bbr.2011.12.014
更新日期：2012-03-17 00:00:00
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journal_title：Behavioural brain research
pub_type： 杂志文章
doi：10.1016/j.bbr.2011.09.038
更新日期：2012-01-15 00:00:00
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journal_title：Behavioural brain research
pub_type： 杂志文章
doi：10.1016/j.bbr.2010.05.037
更新日期：2010-12-25 00:00:00
abstract：:One of the routine memory abilities impaired in amnesic patients with temporal-lobe damage is object-recognition memory--the ability to discriminate the familiarity of previously encountered objects. Reproducing this impairment has played a central role in animal models of amnesia during the past two decades, and unti...
journal_title：Behavioural brain research
pub_type： 杂志文章,评审
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更新日期：2001-12-14 00:00:00
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journal_title：Behavioural brain research
pub_type： 杂志文章
doi：10.1016/j.bbr.2006.07.021
更新日期：2006-11-01 00:00:00
abstract：:Within the Pavlovian conditioning framework, extinction is a procedure in which, after conditioning, the conditioned stimulus (CS) is repeatedly presented without the unconditioned stimulus (US). During this procedure the conditioned response (CR) is gradually attenuated. It has been suggested that extinction during t...
journal_title：Behavioural brain research
pub_type： 杂志文章
doi：10.1016/j.bbr.2014.08.009
更新日期：2014-11-01 00:00:00
abstract：:Experimental validation of cell replacement therapy as a treatment of neurodegenerative diseases requires the demonstration of graft-mediated behavioural recovery. The Corridor task proved to be simple and efficient to conduct with a robust ipsilateral retrieval bias in our rodent Huntington's disease model. The Corri...
journal_title：Behavioural brain research
pub_type： 杂志文章
doi：10.1016/j.bbr.2007.02.030
更新日期：2007-05-16 00:00:00
abstract：:Unilateral microinjections of bethanechol chloride into the CA3 subfield of the dorsal hippocampus in unrestrained rats produced a seizure-related type behavioural and disseminated brain damage syndrome. Injection of bethanechol in the dose of 50 micrograms resulted in locomotor activation, mouth movements, teeth chat...
journal_title：Behavioural brain research
pub_type： 杂志文章
doi：10.1016/0166-4328(83)90026-8
更新日期：1983-03-01 00:00:00
abstract：:Addiction is a behavioral disorder characterized by the compulsive seeking and taking of drugs despite serious negative consequences. In particular, the chronic use of drugs impairs memory and cognitive functions, which aggravates the loss of control over drug use and complicates treatment outcome. Therefore, cognitiv...
journal_title：Behavioural brain research
pub_type： 杂志文章,评审
doi：10.1016/j.bbr.2012.09.025
更新日期：2013-01-15 00:00:00
abstract：:This review gives an overview of those in vivo imaging studies on synaptic neurotransmission, which so far have been performed on patients with movement disorders and/or dementia. Thereby, the focus is on disease-related deficiencies within the functional entity of the dopaminergic, serotonergic, cholinergic, glutamat...
journal_title：Behavioural brain research
pub_type： 杂志文章,评审
doi：10.1016/j.bbr.2009.06.008
更新日期：2009-12-01 00:00:00
