Abstract:
:Addiction is a behavioral disorder characterized by the compulsive seeking and taking of drugs despite serious negative consequences. In particular, the chronic use of drugs impairs memory and cognitive functions, which aggravates the loss of control over drug use and complicates treatment outcome. Therefore, cognitive enhancers targeting acetylcholine have been proposed to treat addiction. Interestingly, histamine H(3) receptor (H(3)R) antagonists/inverse agonists stimulate acetylcholine transmission in different brain areas, facilitate memory in animal models and can reverse learning deficits induced by drugs such as scopolamine, dizocilpine and alcohol. Moreover, several studies found that compounds capable of activating the histaminergic system generally decrease the reinforcing effects of drugs, namely alcohol and opioids, in preclinical models of addiction. Finally, several H(3)R antagonists/inverse agonists increase histamine in the brain and have proven to be safe in humans. However, no studies have yet investigated the therapeutic potential of cognitive enhancing H(3)R antagonists/inverse agonists in the treatment of addiction in humans. The present review first describes the impact of addictive drugs on learning processes and cognitive functions that play an important role for addicts to remain abstinent. Second, our work briefly summarizes the relevant literature describing the function of histamine in learning, memory and drug addiction. Finally, the potential therapeutic use of histaminergic agents in the treatment of addiction is discussed. Our review suggests that histaminergic compounds like H(3)R antagonists/inverse agonists may improve the treatment outcome of addiction by reversing drug-induced cognitive deficits and/or diminishing the reinforcing properties of addictive drugs, especially opioids and alcohol.
journal_name
Behav Brain Resjournal_title
Behavioural brain researchauthors
Alleva L,Tirelli E,Brabant Cdoi
10.1016/j.bbr.2012.09.025subject
Has Abstractpub_date
2013-01-15 00:00:00pages
357-68eissn
0166-4328issn
1872-7549pii
S0166-4328(12)00611-0journal_volume
237pub_type
杂志文章,评审abstract::Severe temporal lobe epilepsy in humans is often associated with loss of neurons in the hippocampus and memory deficits. In Experiment 1, 60 min of continuous electrical stimulation of the perforant path sufficient to produce seizures resembling status epilepticus and loss of hilar and pyramidal cells in the hippocamp...
journal_title:Behavioural brain research
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abstract::Males from two substrains of C57BL/6J mice, which have been found to differ for open-field exploration, radial-maze learning, and the sizes of their hippocampal intra- and infra-pyramidal mossy fibre (IIPMF) terminal fields, were compared for offensive aggression, thermoregulatory nest-building, and their behaviour in...
journal_title:Behavioural brain research
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doi:10.1016/s0166-4328(98)00049-7
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abstract::In this paper, we develop an animal model of prehension movements by examining the kinematics of reaching and grasping in monkeys and by comparing the results to published data on humans. Hand movements were recorded in three dimensions in monkeys who were trained to either point at visual targets under unperturbed an...
journal_title:Behavioural brain research
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abstract::To determine whether monkeys can navigate a virtual environment, and whether they can represent a virtual environment in their brain, we trained two macaque monkeys to perform a navigation task in a virtual building and conducted behavioral analyses. After learning the task from the first starting point, they were tra...
journal_title:Behavioural brain research
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journal_title:Behavioural brain research
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journal_title:Behavioural brain research
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journal_title:Behavioural brain research
pub_type: 杂志文章
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journal_title:Behavioural brain research
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journal_title:Behavioural brain research
pub_type: 杂志文章
doi:10.1016/j.bbr.2008.09.007
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journal_title:Behavioural brain research
pub_type: 杂志文章
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doi:10.1016/0166-4328(81)90039-5
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journal_title:Behavioural brain research
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journal_title:Behavioural brain research
pub_type: 杂志文章
doi:10.1016/j.bbr.2014.04.027
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journal_title:Behavioural brain research
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doi:10.1016/j.bbr.2014.05.015
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journal_title:Behavioural brain research
pub_type: 杂志文章
doi:10.1016/j.bbr.2005.04.013
更新日期:2005-08-30 00:00:00
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journal_title:Behavioural brain research
pub_type: 杂志文章
doi:10.1016/0166-4328(85)90060-9
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journal_title:Behavioural brain research
pub_type: 杂志文章
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journal_title:Behavioural brain research
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journal_title:Behavioural brain research
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journal_title:Behavioural brain research
pub_type: 杂志文章
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journal_title:Behavioural brain research
pub_type: 杂志文章
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journal_title:Behavioural brain research
pub_type: 杂志文章
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journal_title:Behavioural brain research
pub_type: 杂志文章
doi:10.1016/j.bbr.2005.03.010
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journal_title:Behavioural brain research
pub_type: 杂志文章
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abstract::Male and female C57BL/6 J mice were tested on the predator odor response task, where they needed to cross through a chamber of scented bedding to reach a sucrose reward. Following the behavioral testing, mouse brains were immunohistochemically labeled for expression of the immediate early gene c-fos. In the presence o...
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journal_title:Behavioural brain research
pub_type: 杂志文章
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journal_title:Behavioural brain research
pub_type: 杂志文章
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journal_title:Behavioural brain research
pub_type: 杂志文章
doi:10.1016/j.bbr.2017.05.036
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