Behavioral outcome measures to improve experimental stroke research.

Abstract:

:Functional recovery after an experimental stroke can be assessed by multiple behavioral tests, however, there is no consensus about which test to use in long-term stroke recovery studies or whether the tests are affected by stroke surgery, post-operative care or behavioral compensation due to repeated testing. This review describes the tests most commonly used to assess motor and sensorimotor function, cognition and mood in stroke animals. Although it is difficult to predict the direction of future research, it may be possible to prevent false-positive results by selecting an appropriate task or a battery of tasks. It is also expected that the upcoming stroke recovery recommendations and the improved dialogue between academy, industry and healthcare professionals will further promote translational success.

journal_name

Behav Brain Res

authors

Balkaya MG,Trueman RC,Boltze J,Corbett D,Jolkkonen J

doi

10.1016/j.bbr.2017.07.039

subject

Has Abstract

pub_date

2018-10-15 00:00:00

pages

161-171

eissn

0166-4328

issn

1872-7549

pii

S0166-4328(17)30732-5

journal_volume

352

pub_type

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