当前位置： SCI文献检索 > BEHAVIOURAL BRAIN RESEARCH期刊下所有文献 > Ameliorative effect of tacrine on spatial memory deficit in chronic two-vessel occluded rats is reversible and mediated by muscarinic M1 receptor stimulation.

Ameliorative effect of tacrine on spatial memory deficit in chronic two-vessel occluded rats is reversible and mediated by muscarinic M1 receptor stimulation.

Abstract：

:Our previous study demonstrated that permanent two-vessel occlusion (2VO)-induced working memory deficit was improved by daily administration of tacrine, a cholinesterase inhibitor. In this study, we investigated the mechanism underlying the effects of tacrine in 2VO rats using the eight-arm radial maze task. Daily administration of tacrine (0.1 or 0.3 mg/kg i.p.) started 5 weeks after the 2VO operation significantly improved the maze performance. In the delay-interposition task, a significant impairment of maze performance was observed in the tacrine (0.3 mg/kg, i.p.)-treated rats at a delay of 90 min but not delays of 5 or 30 min. Sham-operated rats were not affected by delay. After leaving animals with no further treatment for 4 weeks, the tacrine-pretreated 2VO rats showed significantly impaired performance compared to the sham-operated control animals. However, the performance of the tacrine-pretreated 2VO rats was significantly improved by restarting the daily administration of tacrine (0.3 mg/kg, i.p.). The effect of tacrine was reversed by the muscarinic antagonist scopolamine and the selective M1 antagonist pirenzepine. Moreover, a microdialysis study revealed that tacrine (1 or 3 mg/kg, i.p.) increased the extracellular acetylcholine (ACh) level for a period of over 3 h in the cerebral cortex of 2VO rats. These findings suggest that the ameliorative effect of tacrine on the spatial memory deficit in 2VO rats is reversible and may be mediated by stimulating the muscarinic M1 receptor via elevation of the extracellular ACh level in the brain.

journal_name

Behav Brain Res

journal_title

Behavioural brain research

authors

Murakami Y,Ikenoya M,Matsumoto K,Li H,Watanabe H

doi

10.1016/s0166-4328(99)00162-x

subject

Has Abstract

pub_date

2000-04-01 00:00:00

pages

83-90

issue

1

eissn

0166-4328

issn

1872-7549

pii

S0166-4328(99)00162-X

journal_volume

109

pub_type

杂志文章

相关文献

BEHAVIOURAL BRAIN RESEARCH文献大全
  • The OXTR gene, implicit learning and social processing: Does empathy evolve from perceptual skills for details?

    abstract：:Oxytocin is an important messenger in the brain that has been linked to a variety of social functions in pharmacological studies. Besides, functional genetic variations on the oxytocin receptor gene have been repeatedly associated with social processing and functioning. Despite this knowledge, there are very few studi...

    journal_title：Behavioural brain research

    pub_type： 杂志文章

    doi：10.1016/j.bbr.2017.04.036

    authors： Melchers M,Montag C,Markett S,Niazy N,Groß-Bölting J,Zimmermann J,Reuter M

    更新日期：2017-06-30 00:00:00

  • The differential hippocampal phosphoproteome of Apodemus sylvaticus paralleling spatial memory retrieval in the Barnes maze.

    abstract：:Protein phosphorylation is a well-known and well-documented mechanism in memory processes. Although a large series of protein kinases involved in memory processes have been reported, information on phosphoproteins is limited. It was therefore the aim of the study to determine a partial and differential phosphoproteome...

    journal_title：Behavioural brain research

    pub_type： 杂志文章

    doi：10.1016/j.bbr.2014.01.047

    authors： Li L,Csaszar E,Szodorai E,Patil S,Pollak A,Lubec G

    更新日期：2014-05-01 00:00:00

  • Long-term effects on motor activity induced by apomorphine or scopolamine after intracerebral injections of cycloheximide or glutamate shortly after hatching in chickens.

    abstract：:Compared to controls, bilateral forebrain injections of cycloheximide or glutamate in 2-day-old chicks resulted in significantly less activity in response to intraperitoneal injections of the dopaminergic agonist, apomorphine, or the cholinergic antagonist, scopolamine, when tested on stabilimeters four weeks later. T...

    journal_title：Behavioural brain research

    pub_type： 杂志文章

    doi：10.1016/0166-4328(82)90038-9

    authors： Sanberg PR,Mark RF

    更新日期：1982-07-01 00:00:00

  • Synthetic cathinones and their phenethylamine analogues produce distinct psychomotor and reward behavior in crayfish.

    abstract：:Synthetic cathinones share potent sympathomimetic properties with amphetamines due to their shared phenethylamine backbone. Despite recent work focused on understanding the behavioral effects of synthetic cathinones, a systematic comparison of neuropharmacology, behavior, and physiological effects with other stimulant...

    journal_title：Behavioural brain research

    pub_type： 杂志文章

    doi：10.1016/j.bbr.2019.112368

    authors： Gore S,van Staaden MJ,Sprague JE,Huber R

    更新日期：2020-02-03 00:00:00

  • Early social stress in female guinea pigs induces a masculinization of adult behavior and corresponding changes in brain and neuroendocrine function.

    abstract：:This study was undertaken to investigate, in guinea pigs, the effects of pre- and early postnatal social stress on the functioning of hormonal-, autonomic-, behavioral-, and limbic-brain systems. Dams had either lived in groups with a constant composition (i.e. stable social environment) or in groups with changing com...

    journal_title：Behavioural brain research

    pub_type： 杂志文章

    doi：10.1016/s0166-4328(03)00077-9

    authors： Kaiser S,Kruijver FP,Swaab DF,Sachser N

    更新日期：2003-09-15 00:00:00

  • Muscimol inactivation of the septo-preoptic complex affects medial forebrain bundle self-stimulation only when directed at the complex's ventrolateral components.

    abstract：:Elements of the septo-preoptic basal forebrain complex, particularly the lateral and medial septum, the diagonal band of Broca, and the magnocellular preoptic area, have been linked to medial forebrain bundle (MFB) self-stimulation. This study examines the roles of these areas in MFB self-stimulation by temporarily in...

    journal_title：Behavioural brain research

    pub_type： 杂志文章

    doi：10.1016/j.bbr.2006.12.005

    authors： Waraczynski M

    更新日期：2007-03-12 00:00:00

  • ZENK expression in a restricted forebrain area correlates negatively with preference for an imprinted stimulus.

    abstract：:Sexual imprinting is an early learning process by which young birds acquire the characteristics of a potential sexual partner. The physiological basis of this learning process is an irreversible reduction of dendritic spines in two forebrain areas, the LNM (lateral nido-mesopallium) and the MNM (medial nido-mesopalliu...

    journal_title：Behavioural brain research

    pub_type： 杂志文章

    doi：10.1016/j.bbr.2006.03.034

    authors： Huchzermeyer C,Husemann P,Lieshoff C,Bischof HJ

    更新日期：2006-07-15 00:00:00

  • Behavioural effects of neocortical and cingulate lesions in the Mongolian gerbil.

    abstract：:The experiments examine the effects of cortical lesions on a variety of behaviours in the Mongolian gerbil (Meriones unguiculatus). Gerbils with either large anterior or posterior lesions were compared with normal gerbils by administering a battery of tests of rodent behaviours such as grooming, eating, social interac...

    journal_title：Behavioural brain research

    pub_type： 杂志文章

    doi：10.1016/0166-4328(90)90158-b

    authors： Ellard CG,Stewart DJ,Donaghy S,Vanderwolf CH

    更新日期：1990-01-01 00:00:00

  • Kindling of hippocampal field CA1 impairs spatial learning and retention in the Morris water maze.

    abstract：:We used two procedures to assess the spatial learning and memory of rats in the Morris water maze task subsequent to kindling of hippocampal field CA1: (1) seizures were kindled with stimulation of CA1 prior to training in the water maze (acquisition); and (2) maze training was imposed until performance stabilized, se...

    journal_title：Behavioural brain research

    pub_type： 杂志文章

    doi：10.1016/s0166-4328(97)81108-4

    authors： Gilbert TH,McNamara RK,Corcoran ME

    更新日期：1996-12-01 00:00:00

  • Availability and characterization of transgenic and knockout mice with behavioral manifestations: where to look and what to search for.

    abstract：:Mice altered by transgenesis or gene targeting ("knockouts") have increasingly been employed as alternative effective tools in elucidating the genetic basis of neurophysiology and behavior. Standardization of specific behavioral paradigms and phenotyping strategies will ensure that these behavioral mouse mutants offer...

    journal_title：Behavioural brain research

    pub_type： 杂志文章

    doi：10.1016/s0166-4328(01)00284-4

    authors： Anagnostopoulos AV,Sharp JJ,Mobraaten LE,Eppig JT,Davisson MT

    更新日期：2001-11-01 00:00:00

  • Resilience against predator stress and dendritic morphology of amygdala neurons.

    abstract：:Individual differences in coping response lie at the core of vulnerability to conditions like post-traumatic stress disorder (PTSD). Like humans, not all animals exposed to severe stress show lasting change in affect. Predator stress is a traumatic experience inducing long-lasting fear, but not in all rodents. Thus, i...

    journal_title：Behavioural brain research

    pub_type： 杂志文章

    doi：10.1016/j.bbr.2009.08.014

    authors： Mitra R,Adamec R,Sapolsky R

    更新日期：2009-12-28 00:00:00

  • Effects of oxytocin on serotonin 1B agonist-induced autism-like behavior in mice.

    abstract：:Social impairments in autism remain poorly understood and without approved pharmacotherapies. Novel animals models are needed to elucidate mechanisms and evaluate novel treatments for the social deficits in autism. Recently, serotonin 1B receptor (5-HT1B) agonist challenge in mice was shown to induce autism-like behav...

    journal_title：Behavioural brain research

    pub_type： 杂志文章

    doi：10.1016/j.bbr.2016.07.027

    authors： Lawson SK,Gray AC,Woehrle NS

    更新日期：2016-11-01 00:00:00

  • Combined effects of exposure to dim light at night and fine particulate matter on C3H/HeNHsd mice.

    abstract：:Air and light pollution contribute to fetal abnormalities, increase prevalence of cancer, metabolic and cardiorespiratory diseases, and central nervous system (CNS) disorders. A component of air pollution, particulate matter, and the phenomenon of dim light at night (dLAN) both result in neuroinflammation, which has b...

    journal_title：Behavioural brain research

    pub_type： 杂志文章

    doi：10.1016/j.bbr.2015.07.033

    authors： Hogan MK,Kovalycsik T,Sun Q,Rajagopalan S,Nelson RJ

    更新日期：2015-11-01 00:00:00

  • Nucleus accumbens lesions decrease sensitivity to rapid changes in the delay to reinforcement.

    abstract：:Both humans and non-humans discount the value of rewards that are delayed or uncertain, and individuals that discount delayed rewards at a relatively high rate are considered impulsive. To investigate the neural mechanisms that mediate delay discounting, the present study examined the effects of excitotoxic lesions of...

    journal_title：Behavioural brain research

    pub_type： 杂志文章

    doi：10.1016/j.bbr.2006.06.024

    authors： Acheson A,Farrar AM,Patak M,Hausknecht KA,Kieres AK,Choi S,de Wit H,Richards JB

    更新日期：2006-10-16 00:00:00

  • Amniotic fluid derived stem cells ameliorate focal cerebral ischaemia-reperfusion injury induced behavioural deficits in mice.

    abstract：:The present study has been designed to investigate the effect of amniotic fluid derived stem cells on focal cerebral ischaemia-reperfusion injury induced behavioural deficits in mice. Middle cerebral artery occlusion of 60 min followed by reperfusion for 7 days was employed in present study to produce ischaemia and re...

    journal_title：Behavioural brain research

    pub_type： 杂志文章

    doi：10.1016/j.bbr.2007.05.028

    authors： Rehni AK,Singh N,Jaggi AS,Singh M

    更新日期：2007-10-01 00:00:00

  • Early exposure to chronic variable stress facilitates the occurrence of anhedonia and enhanced emotional reactions to novel stressors: reversal by naltrexone pretreatment.

    abstract：:The present research studied the influence of an early chronic variable stress (CVS) paradigm - an animal model of depression - on behavioral responses to subsequent environmental challenges suggested to model anhedonia and emotional reactions such as anxiety and fear. In order to explore a potential involvement of an...

    journal_title：Behavioural brain research

    pub_type： 杂志文章

    doi：10.1016/s0166-4328(00)00302-8

    authors： Zurita A,Martijena I,Cuadra G,Brandão ML,Molina V

    更新日期：2000-12-20 00:00:00

  • Transcranial direct current stimulation (tDCS) of frontal cortex decreases performance on the WAIS-IV intelligence test.

    abstract：:Transcranial direct current stimulation (tDCS) modulates excitability of motor cortex. However, there is conflicting evidence about the efficacy of this non-invasive brain stimulation modality to modulate performance on cognitive tasks. Previous work has tested the effect of tDCS on specific facets of cognition and ex...

    journal_title：Behavioural brain research

    pub_type： 杂志文章

    doi：10.1016/j.bbr.2015.04.031

    authors： Sellers KK,Mellin JM,Lustenberger CM,Boyle MR,Lee WH,Peterchev AV,Fröhlich F

    更新日期：2015-09-01 00:00:00

  • The temporal locus of transfer of training between hands: an interference study.

    abstract：:Two experiments are presented which used a dual-task interference procedure to examine the temporal locus of lateral transfer of training. In Experiment 1, 120 undergraduates practised a sequential tapping task with either the left or the right hand, and then switched to the opposite, untrained hand for the test trial...

    journal_title：Behavioural brain research

    pub_type： 杂志文章

    doi：10.1016/s0166-4328(05)80091-9

    authors： Parlow SE,Dewey D

    更新日期：1991-12-13 00:00:00

  • Voluntary exercise reduces plasma cortisol levels and improves transitory memory impairment in young and aged Octodon degus.

    abstract：:Sleep deprivation (SD) has been reported to induce transient cognitive impairment in functional domains commonly affected in dementia, including memory. Indeed, sleep disturbance has been proposed as an early marker for Alzheimer's disease (AD). SD emulates many aging-related modifications, including important memory ...

    journal_title：Behavioural brain research

    pub_type： 杂志文章

    doi：10.1016/j.bbr.2019.112066

    authors： Estrada C,Cuenca L,Cano-Fernandez L,Gil-Martinez AL,Sanchez-Rodrigo C,González-Cuello AM,Fernandez-Villalba E,Herrero MT

    更新日期：2019-11-05 00:00:00

  • The effects of the intraamygdalar melatonin injections on the anxiety like behavior and the spatial memory performance in male Wistar rats.

    abstract：:In the present study, the effects of intraamygdalar administrations of melatonin (1 and 100μg/kg), saline and diazepam on the anxiety-like behavior and spatial memory performance in pinealectomized and sham-pinealectomized Wistar rats were investigated. The animals were tested by open field and elevated plus maze test...

    journal_title：Behavioural brain research

    pub_type： 杂志文章

    doi：10.1016/j.bbr.2011.03.029

    authors： Karakaş A,Coşkun H,Kaya A,Kücük A,Gündüz B

    更新日期：2011-09-12 00:00:00

  • Nucleus accumbens, entorhinal cortex and latent inhibition: a neural network model.

    abstract：:A neural network model of classical conditioning (Schmajuk, Lam, and Gray, J. Exp. Psychol.: Anim. Behav. Process, 22, 1996, 321-349) is applied to the description of the neural substrates of latent inhibition. Experimental data suggest that latent inhibition might be controlled by a circuit that involves the hippocam...

    journal_title：Behavioural brain research

    pub_type： 杂志文章

    doi：10.1016/s0166-4328(00)00319-3

    authors： Schmajuk NA,Cox L,Gray JA

    更新日期：2001-01-29 00:00:00

  • Modulating activity in the prefrontal cortex changes decision-making for risky gains and losses: a transcranial direct current stimulation study.

    abstract：:When making choices under uncertainty, people usually consider both the risks and benefits of each option. Previous studies have found that weighing of risks and benefits during decision-making involves a complex neural network that includes the dorsolateral prefrontal cortex (DLPFC), but the causal effect of this net...

    journal_title：Behavioural brain research

    pub_type： 杂志文章

    doi：10.1016/j.bbr.2015.02.037

    authors： Ye H,Chen S,Huang D,Wang S,Luo J

    更新日期：2015-06-01 00:00:00

  • Behavioral response to novelty correlates with dopamine receptor availability in striatum of Göttingen minipigs.

    abstract：:Behavioral response to novelty in rats has been linked both to dopamine transmission in the ventral striatum, and to propensity to self-administer psychostimulant drugs. In order to probe the relationship between behavioral response to novelty and dopamine systems we have developed a behavioral model for correlation w...

    journal_title：Behavioural brain research

    pub_type： 杂志文章

    doi：10.1016/j.bbr.2005.06.008

    authors： Lind NM,Gjedde A,Moustgaard A,Olsen AK,Jensen SB,Jakobsen S,Arnfred SM,Hansen AK,Hemmingsen RP,Cumming P

    更新日期：2005-11-07 00:00:00

  • Rearing with artificially scented mothers attenuates conditioned odor aversion in adulthood but not its amygdala dependency.

    abstract：:The aim of the present study was to investigate whether neonatal odor experience associated with the mother affects food avoidance learning and basolateral amygdala (BLA) involvement in adulthood. Odorization of mother's nipples with banana or almond solutions from birth to weaning resulted in an impairment at adultho...

    journal_title：Behavioural brain research

    pub_type： 杂志文章

    doi：10.1016/j.bbr.2008.11.003

    authors： Sevelinges Y,Lévy F,Mouly AM,Ferreira G

    更新日期：2009-03-17 00:00:00

  • The study on the frontoparietal networks by continuous theta burst stimulation in healthy human subjects.

    abstract：:Frontoparietal networks (FPNs) including the regions of the posterior parietal cortex (PPC) and dorsolateral prefrontal cortex (DLPFC) have been implicated in visuospatial attention. However, the functional interactions among different regions of dorsal FPNs remain elusive. The Attention Network Test (ANT) and continu...

    journal_title：Behavioural brain research

    pub_type： 杂志文章,随机对照试验

    doi：10.1016/j.bbr.2012.11.015

    authors： Xu G,Lan Y,Huang D,Chen S,Chen L,Zeng J,Pei Z

    更新日期：2013-03-01 00:00:00

  • Affective profiling for anxiety-like behavior in a rodent model of mTBI.

    abstract：:Mild traumatic brain injury is a common outcome of blast exposure, and current literature indicates high rates of comorbid posttraumatic stress disorder (PTSD) in military personnel. Blast-exposed rats display PTSD-like behavior, suggesting relationships may exist between PTSD and blast exposure. Other studies demonst...

    journal_title：Behavioural brain research

    pub_type： 杂志文章

    doi：10.1016/j.bbr.2019.04.009

    authors： Statz JK,Ciarlone SL,Goodrich JA,McCarron RM,Walker PB,Norris JN,Ahlers ST,Tschiffely AE

    更新日期：2019-08-05 00:00:00

  • Preservation of perceptual integration improves temporal stability of bimanual coordination in the elderly: an evidence of age-related brain plasticity.

    abstract：:Despite the apparent age-related decline in perceptual-motor performance, recent studies suggest that the elderly people can improve their reaction time when relevant sensory information are available. However, little is known about which sensory information may improve motor behaviour itself. Using a synchronization ...

    journal_title：Behavioural brain research

    pub_type： 杂志文章

    doi：10.1016/j.bbr.2014.08.043

    authors： Blais M,Martin E,Albaret JM,Tallet J

    更新日期：2014-12-15 00:00:00

  • Amygdalar activation of group I metabotropic glutamate receptors produces anti- and pro-conflict effects depending upon animal sex in a sexually dimorphic conditioned conflict-based anxiety model.

    abstract：:Women are more susceptible than men to develop anxiety disorders, however, the mechanisms involved are still unclear. In this study, we investigated the role of group I metabotropic glutamate receptors (mGluRs), a target for anxiety disorders, and whether estradiol may modulate conflict-based anxiety in female rats by...

    journal_title：Behavioural brain research

    pub_type： 杂志文章

    doi：10.1016/j.bbr.2016.01.009

    authors： De Jesús-Burgos MI,González-García S,Cruz-Santa Y,Pérez-Acevedo NL

    更新日期：2016-04-01 00:00:00

  • Deficit in emotional learning in neurotrimin knockout mice.

    abstract：:Neurotrimin (Ntm) belongs to the IgLON family of cell adhesion molecules with Lsamp, Obcam and kilon that regulate the outgrowth of neurites mostly by forming heterodimers. IgLONs have been associated with psychiatric disorders, intelligence, body weight, heart disease and tumours. This study provides an initial behav...

    journal_title：Behavioural brain research

    pub_type： 杂志文章

    doi：10.1016/j.bbr.2016.09.064

    authors： Mazitov T,Bregin A,Philips MA,Innos J,Vasar E

    更新日期：2017-01-15 00:00:00

  • Age-related deficits in the retention of memories for cued fear conditioning are reversed by galantamine treatment.

    abstract：:Aging has diverse effects on different behaviors and underlying neural systems. This study utilized fear conditioning to determine if aged mice have deficits in the acquisition and/or retention of memories for contextual or cued fear conditioning, and to determine if galantamine, an acetylcholinesterase (AChE) inhibit...

    journal_title：Behavioural brain research

    pub_type： 杂志文章

    doi：10.1016/j.bbr.2005.06.040

    authors： Gould TJ,Feiro OR

    更新日期：2005-12-07 00:00:00