Abstract：
:In earlier experiments we have demonstrated that group-housing in a rather impoverished "standard" environment can be a crucial stress factor in male C57Bl/6 mice. The present study aimed at investigating the effect of combining a probable genetic vulnerability--postulated by the "Neurotrophin Hypothesis of Depression"--with the potentially modulating influence of a stressful environment such as "impoverished" standard housing conditions. For that purpose mice with a partial deletion of brain-derived neurotrophic factor (BDNF) were group-housed under standard and enriched housing conditions and analysed in a well-established test battery for emotional behaviours. Standard group-housing affected emotional behaviour in male and female BDNF heterozygous mice, causing an increase in anxiety, changes in exploration as well as nociception. Providing the animals' cages with supplementary enrichment, however, led to a rescue of emotional alterations, which emphasises the significance of external factors and their relevance for a valid investigation of genetic aspects in these mutants as well as others, which may be examined in terms of stress-responsiveness or emotionality.
journal_name
Behav Brain Resjournal_title
Behavioural brain researchauthors
Chourbaji S,Brandwein C,Vogt MA,Dormann C,Hellweg R,Gass Pdoi
10.1016/j.bbr.2008.04.015subject
Has Abstractpub_date
2008-10-10 00:00:00pages
254-8issue
2eissn
0166-4328issn
1872-7549pii
S0166-4328(08)00228-3journal_volume
192pub_type
杂志文章abstract：:There is no satisfactory therapeutic intervention for neonatal hypoxic-ischemic (HI) encephalopathy. Progesterone is known to be effective in treating traumatic brain injury in adult animals but its effects in neonatal brains have not been reported. Brain injuries were induced by a unilateral common carotid artery lig...
journal_title：Behavioural brain research
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abstract：:This study investigated the role of the noradrenergic (NA) and the serotoninergic (5-HT) centrifugal fibers on the olfactory bulb (OB). For this purpose, behavioral responses largely depending on olfactory information were measured in rats after discrete bilateral injections into the OB with either 6-hydroxydopamine (...
journal_title：Behavioural brain research
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abstract：:Mildronate (3-(2,2,2-trimethylhydrazinium) propionate) is an inhibitor of l-carnitine biosynthesis and an anti-ischemic drug. In the present study, we investigated the effects of mildronate in rats following focal cerebral ischemia. Male Wistar rats were subjected to transient occlusion of the middle cerebral artery (...
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abstract：:Latent inhibition (LI) is a behavioural procedure used to evaluate the potential propsychotic and antipsychotic properties of psychoactive drugs. In the present study, a conditioned taste aversion (CTA) procedure was used to investigate the effects of the nitric oxide (NO) synthase inhibitor, N(G)-nitro-L-arginine met...
journal_title：Behavioural brain research
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abstract：:Intake despite negative consequences (compulsivity) contributes strongly to the harm of alcohol use disorder, making the underlying psychological and circuit mechanisms of great importance. To gain insight into possible underlying action strategies, we compared rat licking microstructure across compulsion-like and non...
journal_title：Behavioural brain research
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journal_title：Behavioural brain research
pub_type： 杂志文章
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更新日期：2014-03-01 00:00:00
abstract：:Since the discovery that certain flavonoids (namely flavones) specifically recognise the central BDZ receptors, several efforts have been made to identify naturally occurring GABA(A) receptor benzodiazepine binding site ligands. Flavonoid derivatives with a flavone-like structure such as apigenin, chrysin and wogonin ...
journal_title：Behavioural brain research
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doi：10.1016/j.bbr.2007.12.010
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abstract：:We investigated the neurobiological bases of variation in response to predator stress (PS). Sixteen days after treatment (PS or handling), rats were grouped according to anxiety in the elevated plus maze (EPM). Acoustic startle was also measured. We examined the structure of dendritic trees of basolateral amygdala (BL...
journal_title：Behavioural brain research
pub_type： 杂志文章
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更新日期：2012-01-01 00:00:00
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abstract：:Mice self-administer morphine into the lateral septum (LS), but the neuronal connections underlying this behaviour remain unknown. The present study tested whether the acquisition of intra-LS morphine self-administration depends on dopaminergic mechanisms. Mice were allowed to self-inject morphine (5 or 20ng/50nl) or ...
journal_title：Behavioural brain research
pub_type： 杂志文章
doi：10.1016/j.bbr.2007.03.014
更新日期：2007-06-18 00:00:00
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journal_title：Behavioural brain research
pub_type： 杂志文章
doi：10.1016/s0166-4328(02)00422-9
更新日期：2003-06-16 00:00:00
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journal_title：Behavioural brain research
pub_type： 杂志文章
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更新日期：2021-01-15 00:00:00
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journal_title：Behavioural brain research
pub_type： 杂志文章
doi：10.1016/j.bbr.2018.12.048
更新日期：2019-04-19 00:00:00
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journal_title：Behavioural brain research
pub_type： 杂志文章
doi：10.1016/j.bbr.2015.05.009
更新日期：2015-09-15 00:00:00
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journal_title：Behavioural brain research
pub_type： 杂志文章
doi：10.1016/j.bbr.2011.05.033
更新日期：2011-10-10 00:00:00
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journal_title：Behavioural brain research
pub_type： 杂志文章
doi：10.1016/j.bbr.2009.09.016
更新日期：2010-01-20 00:00:00
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journal_title：Behavioural brain research
pub_type： 杂志文章,评审
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更新日期：2009-05-16 00:00:00
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journal_title：Behavioural brain research
pub_type： 杂志文章
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更新日期：2018-10-01 00:00:00
abstract：:Previous exposure to amphetamine attenuates its ability to induce conditioned taste aversion (CTA). Because amphetamine, unlike emetic agents like LiCl, possesses appetitive properties that sensitize when it is administered repeatedly, the present study assessed the contribution of sensitization to this US-pre-exposur...
journal_title：Behavioural brain research
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abstract：:Experimental validation of cell replacement therapy as a treatment of neurodegenerative diseases requires the demonstration of graft-mediated behavioural recovery. The Corridor task proved to be simple and efficient to conduct with a robust ipsilateral retrieval bias in our rodent Huntington's disease model. The Corri...
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journal_title：Behavioural brain research
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journal_title：Behavioural brain research
pub_type： 杂志文章
doi：10.1016/j.bbr.2007.09.005
更新日期：2008-03-05 00:00:00
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更新日期：2013-04-15 00:00:00
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journal_title：Behavioural brain research
pub_type： 杂志文章
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更新日期：1982-12-01 00:00:00
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journal_title：Behavioural brain research
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journal_title：Behavioural brain research
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更新日期：2013-11-15 00:00:00
abstract：:Deep brain stimulation (DBS) has gained interest as a potential therapy for advanced treatment-resistant dementia. However, possible targets for DBS and the optimal stimulation parameters are not yet clear. Here, we compared the effects of DBS of the CA1 sub-region of the hippocampus, mammillothalamic tract, anterior ...
journal_title：Behavioural brain research
pub_type： 杂志文章
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更新日期：2015-10-01 00:00:00
abstract：:Previous data have shown that the rat model of melatonin deficit can cause a number of neurobiological aberrations. The aim of the present study was to determine whether the antidepressant drug agomelatine, a MT1/MT2 melatoninergic receptor agonist/5-HT2C receptor antagonist is able to prevent some of the behavioral, ...
journal_title：Behavioural brain research
pub_type： 杂志文章
doi：10.1016/j.bbr.2015.12.043
更新日期：2016-04-01 00:00:00
