Abstract：
:The APOE-ɛ4 allele is associated with increased cognitive decline during normal aging and Alzheimer's disease. However, several studies intriguingly found a beneficial effect on cognition in young adult human APOE-ɛ4 carriers. Here, we show that 3-month old bigenic hAPP-Yac/apoE4-TR mice outperformed their hAPP-Yac/apoE3-TR counterparts on learning and memory performances in the highly hippocampus-dependent, hidden-platform version of the Morris water maze task. The two mouse lines did not differ in a non-spatial visible-platform version of the task. This hAPP-Yac/apoE-TR model may thus provide a useful tool to study the mechanisms involved in the antagonistic pleiotropic effects of APOE-ɛ4 on cognitive functions.
journal_name
Behav Brain Resjournal_title
Behavioural brain researchauthors
Moreau PH,Bott JB,Zerbinatti C,Renger JJ,Kelche C,Cassel JC,Mathis Cdoi
10.1016/j.bbr.2012.12.043subject
Has Abstractpub_date
2013-04-15 00:00:00pages
1-5eissn
0166-4328issn
1872-7549pii
S0166-4328(12)00833-9journal_volume
243pub_type
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