Abstract:
:Previous exposure to amphetamine attenuates its ability to induce conditioned taste aversion (CTA). Because amphetamine, unlike emetic agents like LiCl, possesses appetitive properties that sensitize when it is administered repeatedly, the present study assessed the contribution of sensitization to this US-pre-exposure effect (US-PEE). It was found that not all sensitizing regimens of systemic amphetamine injections produce a US-PEE. In addition, previous exposure to amphetamine in the VTA, where it acts to induce sensitization but not CTA, did not produce a US-PEE. It is concluded that amphetamine sensitization alone does not modulate this drug's ability to produce CTA. Implications of these findings for anatomically based associative and non-associative models of CTA and the US-PEE are discussed.
journal_name
Behav Brain Resjournal_title
Behavioural brain researchauthors
Scott-Railton J,Arnold G,Vezina Pdoi
10.1016/j.bbr.2006.08.036subject
Has Abstractpub_date
2006-12-15 00:00:00pages
305-14issue
2eissn
0166-4328issn
1872-7549pii
S0166-4328(06)00495-5journal_volume
175pub_type
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