Abstract:
UNLABELLED:Evidence from in situ studies supports the role of anti-apoptotic factors in the antidepressant responses of certain psychotropics. The availability of anti-ceramidase pro-apoptocic compound (LCL385) provides an opportunity to test in vivo the relation between hippocampal apopotosis and learned helplessness. METHOD:40 Sprague-Dawley male rodents underwent an FST after a treatment with LCL385, desipramine (DMI), or placebo (SAL) over 3 days. Behavioral responses, including immobility, swimming and climbing were counted during the 6min test. Western blot labeling was used to detect anti-apoptosis in hippocampus. RESULTS:DMI alone was associated with reduced immobility and increased climbing whereas LCL385 alone showed a decrease in Bcl-2/beta-actin ratio. CONCLUSIONS:Direct modulation of Bcl-2 expression in the hippocampus is not associated with learned helplessness in stressed rats. Three-day administration of DMI and LCL385 show divergent effects on behavioral and anti-apoptotic measures.
journal_name
Behav Brain Resjournal_title
Behavioural brain researchauthors
Nahas Z,Jiang Y,Zeidan YH,Bielawska A,Szulc Z,Devane L,Kalivas P,Hannun YAdoi
10.1016/j.bbr.2008.07.040subject
Has Abstractpub_date
2009-01-30 00:00:00pages
41-4issue
1eissn
0166-4328issn
1872-7549pii
S0166-4328(08)00410-5journal_volume
197pub_type
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