Abstract：
:We have found that protein malnutrition (PM) causes a significant impairment of memory-related behavior on the 15th and 20th day after the start of PM (5% casein) feeding in prepubertal mice but not in postpubertal mice, as measured by a passive-avoidance task. This impairment was almost completely reversed by merely switching to a standard protein (20% casein) diet on the 10th day after the start of PM. However, the reversal was not observed when the switching to a standard protein regimen was done on the 15th day of the PM diet. Interestingly, the impairment of memory-related behavior on the 20th day was improved by the chronic administration of physostigmine (0.1 mg/kg/day x last 10 days, i.p.), a cholinesterase inhibitor. To correlate brain cholinergic neuron function with the memory-related behavior impairment induced by PM, microphotometry was used to determine the histological distribution of the imunofluorescence intensity for choline acetyltransferase (ChAT), a functional marker of presynapse in cholinergic neurons. The change in the intensity of fluorescence indicated that ChAT protein was decreased in the hippocampus (CA1, CA3 and dentate gyrus) on the 20th day after PM feeding in comparison with controls. These results suggest the possibility that the memory-related behavior deficits observed in prepubertal mice with PM are caused by a dysfunction of the cholinergic neurons in the hippocampus.
journal_name
Behav Brain Resjournal_title
Behavioural brain researchauthors
Nakagawasai O,Yamadera F,Sato S,Taniguchi R,Hiraga H,Arai Y,Murakami H,Mawatari K,Niijima F,Tan-No K,Tadano Tdoi
10.1016/j.bbr.2005.08.024subject
Has Abstractpub_date
2006-02-15 00:00:00pages
111-7issue
1eissn
0166-4328issn
1872-7549pii
S0166-4328(05)00376-1journal_volume
167pub_type
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