Abstract：
:In order to investigate the relative contribution of dopaminergic projections to the nucleus accumbens and prefrontal cortex in the regulation of spontaneous and drug-induced locomotor activity, separate groups of rats were prepared with 6-OHDA lesions of the ventral tegmental area alone, or additional grafts of dopamine-rich tissue reinnervating either the nucleus accumbens or medial prefrontal cortex. A fourth unoperated group served as normal controls. The lesions induced no change in spontaneous, daytime activity, but increased overnight activity. The lesioned rats were also hyperactive to apomorphine, while the activational effects of amphetamine were blocked. Grafts of dopamine-rich tissue, whether into the prefrontal cortex or nucleus accumbens, resulted in a significant normalization of both drug responses towards control levels. Neither graft influenced overnight hyperactivity, whereas spontaneous daytime activity was increased above both control and lesion levels by the accumbens grafts alone. The results are interpreted as suggesting that dopaminergic projections to prefrontal cortex and nucleus accumbens are similarly rather than antagonistically involved in the regulation of drug-induced locomotor activation.
journal_name
Behav Brain Resjournal_title
Behavioural brain researchauthors
Dunnett SB,Bunch ST,Gage FH,Björklund Adoi
10.1016/0166-4328(84)90031-7subject
Has Abstractpub_date
1984-07-01 00:00:00pages
71-82issue
1eissn
0166-4328issn
1872-7549pii
0166-4328(84)90031-7journal_volume
13pub_type
杂志文章abstract：:The human apolipoprotein E isoforms, apoE2, apoE3, and apoE4, have differential effects on brain function. Compared to apoE3, apoE4 increases the risk of age-related cognitive decline in humans and female mice expressing apoE in neurons. Here, we show impaired spatial memory retention in female mice expressing apoE4 i...
journal_title：Behavioural brain research
pub_type： 杂志文章
doi：10.1016/j.bbr.2006.10.024
更新日期：2007-01-25 00:00:00
abstract：:The effects of various hippocampal manipulations on the classically conditioned nictitating membrane (NM) response were simulated by a real-time attentional-associative model. The model incorporates: (a) a mechanism capable of establishing associations between conditioned (CS) and unconditioned stimuli (US) and betwee...
journal_title：Behavioural brain research
pub_type： 杂志文章
doi：10.1016/s0166-4328(89)80083-x
更新日期：1989-03-01 00:00:00
abstract：:Both humans and non-humans discount the value of rewards that are delayed or uncertain, and individuals that discount delayed rewards at a relatively high rate are considered impulsive. To investigate the neural mechanisms that mediate delay discounting, the present study examined the effects of excitotoxic lesions of...
journal_title：Behavioural brain research
pub_type： 杂志文章
doi：10.1016/j.bbr.2006.06.024
更新日期：2006-10-16 00:00:00
abstract：:Mild traumatic brain injury (mTBI), caused by an insult to the head, results in a cascade of molecular imbalance that includes altered glucose metabolism, mitochondrial dysfunction, and increases in reactive oxygen species. Although glucose is the primary energy source for the brain, it becomes an inefficient substrat...
journal_title：Behavioural brain research
pub_type： 杂志文章
doi：10.1016/j.bbr.2019.112225
更新日期：2019-12-30 00:00:00
abstract：:Maternal alcohol consumption during pregnancy may cause neurocognitive and behavioral disorders that can persist until adulthood. Epidemiological data has revealed an alarming increase in the frequency of alcohol intake in pregnant women. Nutritional variables may also have an impact on the behavioral alterations occa...
journal_title：Behavioural brain research
pub_type： 杂志文章
doi：10.1016/j.bbr.2019.112022
更新日期：2019-10-17 00:00:00
abstract：:The present study aimed at determining whether or not the comprehension of symbolic gestures, and corresponding-in-meaning words, makes use of cortical circuits involved in movement execution control. Participants were presented with videos of an actress producing meaningful or meaningless gestures, pronouncing corres...
journal_title：Behavioural brain research
pub_type： 杂志文章
doi：10.1016/j.bbr.2013.11.025
更新日期：2014-02-01 00:00:00
abstract：:Diminished dopamine D1 stimulation may contribute to cognitive impairment in Alzheimer's and Parkinson's diseases, schizophrenia, and other neuropsychiatric disorders. However, orthosteric D1 receptor (D1R) agonists produce receptor desensitization and an inverted U-shaped dose-response curve, but positive allosteric ...
journal_title：Behavioural brain research
pub_type： 杂志文章
doi：10.1016/j.bbr.2018.12.006
更新日期：2019-04-01 00:00:00
abstract：:Serotonin plays a major role in sensory processing especially with in the primary auditory cortex. The so-called loudness dependence of auditory evoked potentials is generated by pyramidal cells of the primary auditory cortex (LDAEP) which are modulated by serotonergic projection fibers to the main regulators of pyram...
journal_title：Behavioural brain research
pub_type： 杂志文章,评审
doi：10.1016/j.bbr.2014.05.042
更新日期：2015-01-15 00:00:00
abstract：:New granule neurons are born in the dentate gyrus region of the hippocampus throughout life. Behavioral effects of slowing or stopping this ongoing neurogenesis are generally observed only in complex cognitive tasks involving high levels of cue or memory interference or in tests of emotion presented after stress expos...
journal_title：Behavioural brain research
pub_type： 杂志文章
doi：10.1016/j.bbr.2019.112152
更新日期：2019-12-30 00:00:00
abstract：:Sleep deprivation impairs performance in emotional memory tasks, however this effect on memory is not completely understood. Possible mechanisms may involve an alteration in neurotransmission systems, as shown by the fact that many drugs that modulate neural pathways can prevent memory impairment by sleep loss. Gastri...
journal_title：Behavioural brain research
pub_type： 杂志文章
doi：10.1016/j.bbr.2017.05.027
更新日期：2017-07-28 00:00:00
abstract：:Exploration in a dark open field undergoes three progressive changes: (i) an initial phase of spending equal amounts of time in various zones of the arena changes to staying in the corners, and ultimately spending most of the time in one corner; (ii) travel paths are first circular and scattered all over the arena, bu...
journal_title：Behavioural brain research
pub_type： 杂志文章
doi：10.1016/j.bbr.2006.04.006
更新日期：2006-08-10 00:00:00
abstract：:The rat medial prefrontal cortex has been suggested to be involved in executive functions and, more specifically, in working memory and response selection. Here, we looked for prefrontal neural correlates as rats performed a modified radial arm maze task that taxed such functions. Rats had to learn the position of fou...
journal_title：Behavioural brain research
pub_type： 杂志文章
doi：10.1016/j.bbr.2010.02.004
更新日期：2010-06-19 00:00:00
abstract：:Taste memory depends on motivational and post-ingestional consequences after a single taste-illness pairing. During conditioned taste aversion (CTA), the taste and visceral pathways reach the nucleus of the solitary tract (NTS), which is the first relay in the CNS and has a vital function in receiving vagal chemical s...
journal_title：Behavioural brain research
pub_type： 杂志文章
doi：10.1016/j.bbr.2014.09.023
更新日期：2015-02-01 00:00:00
abstract：:Previous work has established that the development of cocaine sensitization is prevented by co-administration of the non-competitive NMDA receptor antagonist MK-801 or by prior ibotenic acid lesions of the medial prefrontal cortex (PFC). The present study examined the effect of these treatments on the expression of co...
journal_title：Behavioural brain research
pub_type： 杂志文章
doi：10.1016/s0166-4328(99)00060-1
更新日期：1999-10-01 00:00:00
abstract：:With increasing age comes an increased risk for sustaining traumatic brain injuries (TBI). However, the effect of age is rarely studied in animal models of TBI. The present study evaluated the effect of increased age on recovery of function following bilateral medial frontal cortex injury. Groups of young (3 months) a...
journal_title：Behavioural brain research
pub_type： 杂志文章
doi：10.1016/j.bbr.2003.11.012
更新日期：2004-08-12 00:00:00
abstract：:Neural activation following sexual behavior was studied in the male and female rat brain, using Fos-immunoreactivity (Fos-IR) as a measure. In accordance with the available literature, we observed increased expression of c-fos in the medial preoptic nucleus (MPN), in the posteromedial subdivision of the bed nucleus of...
journal_title：Behavioural brain research
pub_type： 杂志文章
doi：10.1016/s0166-4328(97)00190-3
更新日期：1998-05-01 00:00:00
abstract：:The avian hippocampal formation has been proposed to play a critical role in the neural regulation of a navigational system used by homing pigeons to locate their loft once in the familiar area near home. In support of this hypothesis, the homing performance of pigeons with target lesions of either the hippocampus or ...
journal_title：Behavioural brain research
pub_type： 杂志文章
doi：10.1016/0166-4328(90)90079-t
更新日期：1990-11-30 00:00:00
abstract：:Recent evidence indicates that the hippocampus contributes to the control of defensive behaviors in rodents. Here, electrical stimulation (1s, 60 Hz) of the rat dorsal hippocampus inhibited defense in the elevated plus maze (increased open arm exploration) and shock-probe burying test (reduced burying duration), while...
journal_title：Behavioural brain research
pub_type： 杂志文章
doi：10.1016/j.bbr.2007.07.030
更新日期：2008-01-10 00:00:00
abstract：:Several animal studies demonstrated that the volatile anesthetic isoflurane could influence the blood-brain barrier (BBB) integrity, which involved the cognitive impairment. Increasing evidence has also shown that the receptor for advanced glycation end-products (RAGE) played a major role in maintaining the integrity ...
journal_title：Behavioural brain research
pub_type： 杂志文章
doi：10.1016/j.bbr.2017.01.012
更新日期：2017-03-30 00:00:00
abstract：:This study addresses whether or not mild, forced treadmill exercise improves learning and increases neurotrophin levels in the basal forebrain (BF). Neurotrophin deficits in the BF have been implicated in Alzheimer's disease, and physical exercise increases neurotrophins. Aged rats exercised for 7 weeks found the hidd...
journal_title：Behavioural brain research
pub_type： 杂志文章
doi：10.1016/j.bbr.2005.11.008
更新日期：2006-04-03 00:00:00
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journal_title：Behavioural brain research
pub_type： 杂志文章
doi：10.1016/j.bbr.2021.113142
更新日期：2021-01-25 00:00:00
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journal_title：Behavioural brain research
pub_type： 杂志文章
doi：10.1016/j.bbr.2009.04.009
更新日期：2009-09-14 00:00:00
abstract：:The Wistar-Kyoto (WKY) rat has been proposed as a model of anxiety vulnerability as it exhibits pronounced behavioral inhibition, passive avoidance, exaggerated startle response, enhanced HPA-axis activation, and active avoidance that is resistant to extinction. Accumulating evidence suggests that WKY rats respond dif...
journal_title：Behavioural brain research
pub_type： 杂志文章
doi：10.1016/j.bbr.2016.07.017
更新日期：2016-10-15 00:00:00
abstract：:Levels of weight gain have hit an epidemic level with rates of overweight and obesity diagnoses topping all-time highs. Elevated body weight has been linked to increased rates of cardiac problems, blood pressure issues, and risk of developing type 2 diabetes. Leptin, a hormone produced by the body that is involved in ...
journal_title：Behavioural brain research
pub_type： 杂志文章
doi：10.1016/j.bbr.2020.112507
更新日期：2020-04-06 00:00:00
abstract：:Injection of the GABA(A) receptor agonist muscimol into the nucleus accumbens shell (AcbSh) elicits robust feeding in satiated rats, but has no effect on water intake. The current study was designed to examine whether intra-AcbSh muscimol injections influence the intake of ethanol solutions in rats trained to drink us...
journal_title：Behavioural brain research
pub_type： 杂志文章
doi：10.1016/j.bbr.2010.08.032
更新日期：2011-01-20 00:00:00
abstract：:Cohorts of rats with excitotoxic retrosplenial cortex lesions were tested on four behavioural tasks sensitive to dysfunctions in prelimbic cortex, anterior cingulate cortex, or both. In this way the study tested whether retrosplenial cortex has nonspatial functions that reflect its anatomical interactions with these f...
journal_title：Behavioural brain research
pub_type： 杂志文章
doi：10.1016/j.bbr.2017.08.010
更新日期：2017-09-29 00:00:00
abstract：:The cyclic adenosine monophosphate (cAMP) is a second messenger and a central component of intracellular signaling pathways that regulate a wide range of biological functions, including memory. Hence, in this work, firstly the time-course of memory formation was determined in an autoshaping learning task, which had al...
journal_title：Behavioural brain research
pub_type： 杂志文章
doi：10.1016/j.bbr.2008.07.033
更新日期：2008-12-16 00:00:00
abstract：:The hippocampus is essentially involved in learning and memory, and is known to be a target for androgen actions. Androgen receptors are densely expressed in CA1 of rat hippocampus, and mediate the effects of testosterone (T) on learning and memory. T depletion or administration can modulate neural function and cognit...
journal_title：Behavioural brain research
pub_type： 杂志文章
doi：10.1016/j.bbr.2007.10.017
更新日期：2008-03-17 00:00:00
abstract：:Rodents previously (Trial 1) experienced in the elevated plus-maze (EPM) apparatus no longer respond to anxiolytic-like drugs during retesting (Trial 2). In view of the fact that the dorsolateral periaqueductal gray (dlPAG) modulates fear/anxiety-like behavior, the present study sought to determine its role in this ph...
journal_title：Behavioural brain research
pub_type： 杂志文章
doi：10.1016/j.bbr.2005.03.010
更新日期：2005-07-01 00:00:00
abstract：:Cocaine-induced hyperactivity was inhibited by a single administration of naloxone (2 and 5 mg/kg, i.p.), an opioid receptor antagonist, and naloxone administered prior to and during the chronic injection of cocaine attenuated the development of both cocaine-induced reverse tolerance and conditioned place preference (...
journal_title：Behavioural brain research
pub_type： 杂志文章
doi：10.1016/s0166-4328(96)00162-3
更新日期：1997-04-01 00:00:00
