Abstract:
:Levels of weight gain have hit an epidemic level with rates of overweight and obesity diagnoses topping all-time highs. Elevated body weight has been linked to increased rates of cardiac problems, blood pressure issues, and risk of developing type 2 diabetes. Leptin, a hormone produced by the body that is involved in energy balance by inhibiting hunger has been implicated as an underlying mechanism that differentially contributes to food-seeking motivation. Using a scientifically validated animal model of obesity, the fatty Zucker rat, which has mutated leptin receptor genes, leptin's role in behavioral motivation can be assessed. Animals were on a 2 -h food access restriction with one-hour access to rewards in session and one hour of free-feeding access. Pre-session and post-session food access differences were evaluated in looking at motivation for food rewards during satiation while responding on differing levels of fixed-ratio schedules. The results showed robust differential behavior from satiation, demonstrating a basis for a biological mechanism involving leptin sensitivity that could underlie obesity. Although further experimentation is needed, understanding leptin could help bridge the gap in our understanding of satiation and non-satiation.
journal_name
Behav Brain Resjournal_title
Behavioural brain researchauthors
Jarmolowicz DP,Schneider TD,Carrillo A,Hudnall JL,Stancato SSdoi
10.1016/j.bbr.2020.112507subject
Has Abstractpub_date
2020-04-06 00:00:00pages
112507eissn
0166-4328issn
1872-7549pii
S0166-4328(19)31261-6journal_volume
383pub_type
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