Abstract：
:Postnatal maternal separation (PMS) has been shown to be associated with an increased vulnerability to psychiatric illnesses in adulthood. However, the underlying neurological mechanisms are not well understood. Here we evaluated its effects on neurogenesis and tonic GABA currents of cortical layer 5 (L5) pyramidal neurons. PMS not only increased cell proliferation in the subventricular zone, cortical layer 1 and hippocampal dentate gyrus in the adult brain, but also promoted the newly generated cells to differentiate into GABAergic neurons, and PMS adult brain maintained higher ratios of GABAergic neurons in the survival of newly generated cells within 5 days immediately post PMS. Additionally, PMS increased the tonic currents at P7-10 and P30-35 in cortical L5 pyramidal cells. Our results suggest that the newly generated GABAergic neurons and the low GABA concentration-activated tonic currents may be involved in the development of psychiatric disorders after PMS.
journal_name
Behav Brain Resjournal_title
Behavioural brain researchauthors
Feng M,Sheng G,Li Z,Wang J,Ren K,Jin X,Jiang Kdoi
10.1016/j.bbr.2013.11.040subject
Has Abstractpub_date
2014-03-01 00:00:00pages
74-82eissn
0166-4328issn
1872-7549pii
S0166-4328(13)00727-4journal_volume
260pub_type
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