Abstract：
:In an effort to develop spatial learning tasks not requiring food or water deprivation for use in studies of recovery of function after brain damage, T-maze spatial alternation learning was examined in intact rats using water maze swim-escape procedures. Consistent with previous studies, rewarded spatial alternation involving food or water deprivation was readily learned by intact rats. However, none of the groups of rats trained in the swim-escape tasks learned to alternate goal arm choices in the water maze at reliable rates. This was true regardless of whether non-correction or correction procedures were used, and regardless of intertrial delay intervals. Although average alternation rates over sessions did increase from chance levels, the majority of the rats did not reach criterion levels, even with as many as 38 consecutive days of testing. In contrast, a conditional spatial alternation task in the water maze, using a win-shift procedure, was readily learned. Surprisingly, a win-stay version of this conditional spatial task was not learned over 21 days of testing. These unexpected constraints on spatial learning and memory processes in rats cannot be attributed simply to failure of spatial information processing, nor to strict limitations on working memory in swim-escape tasks, since excellent spatial navigation abilities have been documented, and mastery of at least some working-memory tasks have now been demonstrated in swim-escape tasks.
journal_name
Behav Brain Resjournal_title
Behavioural brain researchauthors
Goodlett CR,Nonneman AJ,Valentino ML,West JRdoi
10.1016/0166-4328(88)90130-1subject
Has Abstractpub_date
1988-06-01 00:00:00pages
275-86issue
3eissn
0166-4328issn
1872-7549pii
0166-4328(88)90130-1journal_volume
28pub_type
杂志文章abstract：:Cocaine-induced hyperactivity was inhibited by a single administration of naloxone (2 and 5 mg/kg, i.p.), an opioid receptor antagonist, and naloxone administered prior to and during the chronic injection of cocaine attenuated the development of both cocaine-induced reverse tolerance and conditioned place preference (...
journal_title：Behavioural brain research
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journal_title：Behavioural brain research
pub_type： 杂志文章
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journal_title：Behavioural brain research
pub_type： 杂志文章,评审
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journal_title：Behavioural brain research
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journal_title：Behavioural brain research
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journal_title：Behavioural brain research
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更新日期：2002-07-18 00:00:00
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journal_title：Behavioural brain research
pub_type： 杂志文章
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更新日期：2019-02-01 00:00:00
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更新日期：2016-04-01 00:00:00
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journal_title：Behavioural brain research
pub_type： 杂志文章,随机对照试验
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更新日期：2009-01-03 00:00:00
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journal_title：Behavioural brain research
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更新日期：2017-06-01 00:00:00
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journal_title：Behavioural brain research
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更新日期：2004-08-12 00:00:00
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journal_title：Behavioural brain research
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更新日期：2017-06-30 00:00:00
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journal_title：Behavioural brain research
pub_type： 临床试验,杂志文章
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更新日期：2002-10-17 00:00:00
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pub_type： 杂志文章
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更新日期：1999-01-01 00:00:00
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更新日期：1986-01-01 00:00:00
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journal_title：Behavioural brain research
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更新日期：2007-03-12 00:00:00
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journal_title：Behavioural brain research
pub_type： 杂志文章
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更新日期：1998-12-01 00:00:00
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journal_title：Behavioural brain research
pub_type： 杂志文章
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更新日期：2019-09-16 00:00:00
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journal_title：Behavioural brain research
pub_type： 杂志文章
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