Abstract:
:Paw use in a task consisting of the removal of a piece of adhesive paper from the snout was investigated in 80 mongrel and pure-bred domestic dogs (Canis familiaris). Population lateralisation was observed, but in opposite directions in the two sexes (animals were not desexed): males preferentially used their left paw, females their right paw. The relationship between immune function and paw preference was then investigated. Some immune parameters (total number of white blood cells including lymphocytes, granulocytes and monocytes; leukocyte formula; total proteins; gamma-globulins) were investigated in a sample of left-pawed (n = 6), right-pawed (n = 6) and ambidextrous (n = 6) dogs. The results showed that the percentage of lymphocytes was higher in left-pawed than in right-pawed and ambidextrous dogs, whereas granulocytes percentage was lower in left-pawed than in right-pawed and ambidextrous dogs. Moreover, total number of lymphocytes cells was higher in left-pawed than in right-pawed and ambidextrous dogs, whereas the number of gamma-globulins was lower in left-pawed than in right-pawed and ambidextrous dogs. These findings represent the first evidence that brain asymmetry modulates immune responses in dogs.
journal_name
Behav Brain Resjournal_title
Behavioural brain researchauthors
Quaranta A,Siniscalchi M,Frate A,Vallortigara Gdoi
10.1016/j.bbr.2004.01.009subject
Has Abstractpub_date
2004-08-31 00:00:00pages
521-5issue
2eissn
0166-4328issn
1872-7549pii
S0166432804000129journal_volume
153pub_type
杂志文章abstract::THY-Tau22 mice constitute an animal model for tau aggregation, a hallmark in Alzheimer's disease (AD) and Tauopathies. Our previous studies have shown learning and memory deficits and changes in synaptic plasticity in the hippocampus in THY-Tau22 mice that are consistent with the learning impairments seen in AD-patien...
journal_title:Behavioural brain research
pub_type: 杂志文章
doi:10.1016/j.bbr.2012.12.008
更新日期:2013-04-01 00:00:00
abstract::The present study investigated the impact of a spared nerve injury (SNI) on the daily performance of rats tested in two instrumental conditioning procedures: the progressive ratio (PR) schedule of food reinforcement to study motivation for an appetitive stimulus, and the 5-choice serial reaction time task (5-CSRTT), a...
journal_title:Behavioural brain research
pub_type: 杂志文章
doi:10.1016/j.bbr.2015.02.050
更新日期:2015-06-01 00:00:00
abstract::Though accumulating literature implicates that cytokines are involved in the pathophysiology of mental disorders, the role of interleukin-6 (IL-6) in learning and memory functions remains unresolved. The present study was undertaken to investigate the effect of IL-6 on amygdala-dependent fear learning. Adult Wistar ra...
journal_title:Behavioural brain research
pub_type: 杂志文章
doi:10.1016/j.bbr.2014.08.052
更新日期:2014-12-15 00:00:00
abstract::Testing of cognitive functions in rodent disease models constitutes a substantial sector of behavioral neuroscience. It is most often needed in phenotyping genetically modified new rodent (usually mouse) lines or in preclinical testing of cognitive effects of new CNS drugs. This review concerns present pitfalls and fu...
journal_title:Behavioural brain research
pub_type: 杂志文章,评审
doi:10.1016/j.bbr.2017.05.040
更新日期:2018-10-15 00:00:00
abstract::Bilateral lesions were made, confined to the orbitofrontal part of the prefrontal cortex (OF) of male WEZOB rats at 3 different ages (30, 45 and 60 days) and behavioural changes were studied in adulthood. In a test situation for intermale aggression OF-lesioned animals showed a higher level of aggression than their co...
journal_title:Behavioural brain research
pub_type: 杂志文章
doi:10.1016/0166-4328(83)90032-3
更新日期:1983-12-01 00:00:00
abstract::Norepinephrine (NE) is involved in a variety of behaviors across vertebrate species. In songbirds, NE is involved in singing and auditory perception, fundamental components of pair formation. Mechanisms of pairing remain poorly understood in avian species. NE is likely involved given its role in vocal communication an...
journal_title:Behavioural brain research
pub_type: 杂志文章
doi:10.1016/j.bbr.2013.05.056
更新日期:2013-09-01 00:00:00
abstract::The Wistar-Kyoto (WKY) rat has been proposed as a model of anxiety vulnerability as it exhibits pronounced behavioral inhibition, passive avoidance, exaggerated startle response, enhanced HPA-axis activation, and active avoidance that is resistant to extinction. Accumulating evidence suggests that WKY rats respond dif...
journal_title:Behavioural brain research
pub_type: 杂志文章
doi:10.1016/j.bbr.2016.07.017
更新日期:2016-10-15 00:00:00
abstract::Using a Y-maze preference test paradigm, we examined the characteristics of the neural networks that integrate trains of rewarding stimulation pulses. Rats compared the rewarding effectiveness of various durations of a test reinforcement to those of 3 durations of a standard reinforcement. By changing the duration of ...
journal_title:Behavioural brain research
pub_type: 杂志文章
doi:10.1016/0166-4328(85)90030-0
更新日期:1985-12-01 00:00:00
abstract::Bipolar disorder is a psychiatric condition characterised by episodes of mania, depression, and underlying mood instability. Anticonvulsant drugs have an established place in the treatment of the disorder, but identifying novel drugs in this class is complicated by the absence of validated animal models. We have evalu...
journal_title:Behavioural brain research
pub_type: 杂志文章
doi:10.1016/j.bbr.2004.08.015
更新日期:2005-03-07 00:00:00
abstract::It has been recently shown that Roman high- (RHA) and low- (RLA) avoidance rats show behavioural divergence in successive negative contrast (SNC) induced in one-way avoidance learning [Torres C, Cándido A, Escarabajal MD, de la Torre L, Maldonado A, Tobeña A, et al. Successive negative contrast effect in one-way avoid...
journal_title:Behavioural brain research
pub_type: 杂志文章
doi:10.1016/j.bbr.2007.07.027
更新日期:2007-12-11 00:00:00
abstract::Many studies have demonstrated that aging is associated with declines in skill acquisition. In the current study, we tested whether older adults could acquire general, transferable knowledge about skill learning processes. Older adult participants learned five different motor tasks. Two older adult control groups perf...
journal_title:Behavioural brain research
pub_type: 杂志文章
doi:10.1016/j.bbr.2007.05.024
更新日期:2007-10-01 00:00:00
abstract::Methylphenidate (MPH) is the most commonly prescribed medication used to treat the symptoms associated with attention-deficit hyperactivity disorder (ADHD). The increase in ADHD diagnosis and MPH use has raised concerns regarding the long-term consequences of early exposure to psychostimulants. Animals studies indicat...
journal_title:Behavioural brain research
pub_type: 杂志文章
doi:10.1016/j.bbr.2009.03.015
更新日期:2009-08-24 00:00:00
abstract::The inferior olive (IO) is a required component of neural circuits controlling the classical conditioning of eyeblink responses. Previous reports indicated that lesioning or inactivating the IO abolishes conditioned eyeblinks (CRs), but there was disagreement regarding the timing of the CR performance deficit. As a re...
journal_title:Behavioural brain research
pub_type: 杂志文章
doi:10.1016/j.bbr.2006.12.012
更新日期:2007-03-12 00:00:00
abstract::Identifying the mechanisms underlying the adverse effects of developmental neurotoxicants enables the design of therapies that can potentially reverse neurobehavioral deficits in adulthood. We administered chlorpyrifos (CPF), a model organophosphate pesticide to pregnant mice and identified visuospatial deficits in ad...
journal_title:Behavioural brain research
pub_type: 杂志文章
doi:10.1016/j.bbr.2009.08.006
更新日期:2009-12-28 00:00:00
abstract::The large variety of available animal models has revealed much on the neurobiology of depression, but each model appears as specific to a significant extent, and distinction between stress response, pathogenesis of depression and underlying vulnerability is difficult to make. Evidence from epidemiological studies sugg...
journal_title:Behavioural brain research
pub_type: 杂志文章
doi:10.1016/j.bbr.2014.03.019
更新日期:2014-07-01 00:00:00
abstract::NC-1900, an active fragment analog of arginine vasopressin [arginine vasopressin-(4-9)], has proved to be capable of improving the spatial memory deficits and the impairments in passive avoidance test. In this study, a novel drug carrier for brain delivery, cationic bovine serum albumin conjugated pegylated nanopartic...
journal_title:Behavioural brain research
pub_type: 杂志文章
doi:10.1016/j.bbr.2006.06.001
更新日期:2006-10-02 00:00:00
abstract::The object recognition task is a commonly used test for the assessment of memory functions in rodents. In this paper different aspects concerning the analysis of object recognition data are discussed. Using a set of experimental studies and fictive data sets, it was shown that the absolute discrimination measure (d1) ...
journal_title:Behavioural brain research
pub_type: 杂志文章
doi:10.1016/j.bbr.2012.03.024
更新日期:2012-07-01 00:00:00
abstract::Sex differences in humans on virtual water maze navigation are well established when overall performance is measured, e.g., by the total time taken to find the hidden platform, total path length, or quadrant dwell time during probe trials. Currently, it is unknown whether males are better spatial learners than females...
journal_title:Behavioural brain research
pub_type: 杂志文章
doi:10.1016/j.bbr.2009.12.019
更新日期:2010-04-02 00:00:00
abstract::Alzheimer's disease (AD) is the most common form of age-related dementia (ARD). Most research directed at understanding the causes of AD is focused on the genetic-based pathology associated with the familial form of this disorder. This is important work and significant progress has been made but 85% of all AD patients...
journal_title:Behavioural brain research
pub_type: 杂志文章
doi:10.1016/j.bbr.2010.05.005
更新日期:2010-12-06 00:00:00
abstract::In a short-distance homing task, golden hamsters derive the homing direction both from visual extra-maze cues and from the integration of the outward journey. The relative importance of visual configurations in the control of homing was assessed by presenting these cues in conflict with path integration. The hamsters ...
journal_title:Behavioural brain research
pub_type: 杂志文章
doi:10.1016/0166-4328(90)90175-e
更新日期:1990-05-28 00:00:00
abstract::Systematically distinguishing genetic liability from other contributing factors is critical for designing a preventive strategy for post-traumatic stress disorder (PTSD). To address this issue, we investigated a murine model exposing C57BL/6j, DBA/2j and BALB/cj mice to repeated stress via exposure to conspecific aggr...
journal_title:Behavioural brain research
pub_type: 杂志文章
doi:10.1016/j.bbr.2015.05.038
更新日期:2015-10-01 00:00:00
abstract::Huntington's disease (HD) is a progressive neurodegenerative disorder, characterised by severe degeneration of basal ganglia, motor abnormalities, impaired cognitive function and emotional disturbances. Many of the distinct neuropathological features of HD are reproduced in rats by intrastriatal injections of the exci...
journal_title:Behavioural brain research
pub_type: 杂志文章
doi:10.1016/j.bbr.2006.10.004
更新日期:2007-01-25 00:00:00
abstract::Zinc is an important element in all cells of the body, having structural, enzymatic, and regulatory functions. In some neurons, zinc is loaded into synaptic vesicles by zinc transporter 3 (ZnT3) and released into the synaptic cleft, where it can modulate neuronal function. ZnT3 knockout (KO) mice lack ZnT3 and thus la...
journal_title:Behavioural brain research
pub_type: 杂志文章
doi:10.1016/j.bbr.2016.12.028
更新日期:2017-03-15 00:00:00
abstract::The effects of two cognition enhancers on avoidance impairment induced by the tricyclic antidepressant amitriptyline were assessed during shuttle-box avoidance acquisition and in previously trained mice of the DBA/2 strain. The nootropic agent piracetam (50, 100 or 200 mg/kg, i.p.) had slight or no effect in mice rece...
journal_title:Behavioural brain research
pub_type: 杂志文章
doi:10.1016/s0166-4328(97)00066-1
更新日期:1997-12-01 00:00:00
abstract::Neurons in the isthmo-optic nucleus (ION) of the avian midbrain receive input predominantly from the ipsilateral optic tectum and project to the contralateral retina. Therefore, lesion in the ION removes tectal efferent signals to the retina in birds. In the present study, we trained Japanese quail to reach a target s...
journal_title:Behavioural brain research
pub_type: 杂志文章
doi:10.1016/j.bbr.2012.05.008
更新日期:2012-08-01 00:00:00
abstract::Physical exercise could be a protective factor against the development of substance use disorders; however, a number of preclinical studies report reward-enhancing effects of exercise for various drugs of abuse. We examined the effects of chronic wheel-running on brain reward sensitivity, reaction to novelty, reward-f...
journal_title:Behavioural brain research
pub_type: 杂志文章
doi:10.1016/j.bbr.2020.112831
更新日期:2020-09-15 00:00:00
abstract::Behavioural, electroencephalographic and neuropathological responses to increasing doses of pilocarpine (100-400 mg/kg) administered intraperitoneally to rats were studied. At the dose of 400 mg/kg pilocarpine produced a sequence of behavioural alterations including staring spells, olfactory and gustatory automatisms ...
journal_title:Behavioural brain research
pub_type: 杂志文章
doi:10.1016/0166-4328(83)90136-5
更新日期:1983-09-01 00:00:00
abstract::Maternal immune activation (MIA) is a newly developed animal model of schizophrenia. It has recently been reported that when MIA is induced with the cytokine inducer polyinosinic-polycytidilic acid (poly I:C) rats do not show deficits in prepulse inhibition (PPI), a test that is often considered a validity benchmark. ...
journal_title:Behavioural brain research
pub_type: 杂志文章
doi:10.1016/j.bbr.2008.02.021
更新日期:2008-06-26 00:00:00
abstract::Amotivation is a major symptom of several psychiatric disorders. However, which specific motivations are most affected in various illnesses is not well understood. In major depressive disorder (MDD), anecdotal evidence suggests the motivation to explore may be especially affected, but direct evidence from either patie...
journal_title:Behavioural brain research
pub_type: 杂志文章
doi:10.1016/j.bbr.2016.09.055
更新日期:2017-01-15 00:00:00
abstract::Mucopolysaccharidosis IIIB (MPSIIIB) is a lysosomal storage disease characterised by progressive central nervous system degeneration in patients, with death usually in the late teens. Serious behavioural problems have been reported in children at the early stages of the disease, such as hyperactivity and severe sleep ...
journal_title:Behavioural brain research
pub_type: 杂志文章
doi:10.1016/j.bbr.2010.01.045
更新日期:2010-06-19 00:00:00