A new measure of hindlimb stepping ability in neonatally spinalized rats.

Abstract:

:One of the most widely used animal models for assessing recovery of locomotor functioning is the spinal rat. Although true differences in locomotor abilities of these animals are exhibited during treadmill testing, current measurement techniques often fail to detect them. The HiJK (Hillyer-Joynes Kinematics) scale was developed in an effort to distinguish more effectively between groups of spinal rats. Scale items were compiled after extensive review of the literature concerning development and analysis of rat locomotion and a thorough examination of the current tools. Treadmill tests for 137 Sprague-Dawley rats were taped and scored. The structure of the scale was tested with principle components and factor analysis, in which six of the eight items accounted for 59% of the variance, while all eight accounted for 78%. Validity tests demonstrate that HiJK is measuring locomotor performance accurately and powerfully. First, the HiJK scale correlates highly (>.8) with the widely used BBB scale and second, as shown with ANOVA, can distinguish between different groups of spinal rats. Reliability of the scale was also analyzed. Cronbach's alpha was shown to be .91, indicating considerable internal consistency. Additionally, inter-rater and intra-rater reliabilities were substantial, with correlations for most items reaching above .80. We believe that the HiJK scale will help researchers verify existing experimental differences, advance the field of spinal cord research, and, hopefully, lead to discovery of methods to enhance recovery of function.

journal_name

Behav Brain Res

authors

Hillyer JE,Joynes RL

doi

10.1016/j.bbr.2009.04.009

subject

Has Abstract

pub_date

2009-09-14 00:00:00

pages

291-302

issue

2

eissn

0166-4328

issn

1872-7549

pii

S0166-4328(09)00226-5

journal_volume

202

pub_type

杂志文章
  • Neural correlates of affective empathy and reinforcement learning in boys with conduct problems: fMRI evidence from a gambling task.

    abstract:BACKGROUND:Conduct problems (CP) comprise abnormal behaviors associated with aberrant aspects of affective empathy as well as learning. However, behavioral measures for affective empathy are challenging, and previous results concerning learning in patients with CP are inconsistent. METHODS:Nineteen boys with CP and 24...

    journal_title:Behavioural brain research

    pub_type: 杂志文章

    doi:10.1016/j.bbr.2016.11.037

    authors: Schwenck C,Ciaramidaro A,Selivanova M,Tournay J,Freitag CM,Siniatchkin M

    更新日期:2017-03-01 00:00:00

  • Older adults can learn to learn new motor skills.

    abstract::Many studies have demonstrated that aging is associated with declines in skill acquisition. In the current study, we tested whether older adults could acquire general, transferable knowledge about skill learning processes. Older adult participants learned five different motor tasks. Two older adult control groups perf...

    journal_title:Behavioural brain research

    pub_type: 杂志文章

    doi:10.1016/j.bbr.2007.05.024

    authors: Seidler RD

    更新日期:2007-10-01 00:00:00

  • 5-HT3 and 5-HT4 receptors in terminal regions of the mesolimbic system.

    abstract::In this brief review, we present the evidence for the regulation of the mesolimbic dopamine system by 5-HT3 and 5-HT4 receptors. A range of studies show good evidence that 5-HT3 receptor antagonists reduce raised mesolimbic dopamine activity by blocking 5-HT3 receptors in terminal parts of the mesolimbic dopamine syst...

    journal_title:Behavioural brain research

    pub_type: 杂志文章,评审

    doi:10.1016/0166-4328(96)00063-0

    authors: Kilpatrick GJ,Hagan RM,Gale JD

    更新日期:1996-01-01 00:00:00

  • The threshold for eliciting the jaw opening reflex in rats is not increased by neonatal capsaicin.

    abstract::Neonatal capsaicin administration has previously been shown to increase the threshold for withdrawal and escape response to noxious thermal, chemical and mechanical stimuli. The reason for these effects is destruction of afferent C-fibers and associated reduction in central substance P levels. In contrast, neonatal ca...

    journal_title:Behavioural brain research

    pub_type: 杂志文章

    doi:10.1016/0166-4328(84)90150-5

    authors: Tal M

    更新日期:1984-08-01 00:00:00

  • Spatial learning induces neurogenesis in the avian brain.

    abstract::It is known from previous work that neurones are born continuously in the ventricular zone of the bird brain. In this study, we show that the amount of cell proliferation in the ventricular zone of the hippocampus (HP) and the hyperstriatum ventrale (HV) is influenced by behavioural experience. Two groups of birds (ma...

    journal_title:Behavioural brain research

    pub_type: 杂志文章

    doi:10.1016/s0166-4328(97)00051-x

    authors: Patel SN,Clayton NS,Krebs JR

    更新日期:1997-12-01 00:00:00

  • The effects of novel cholinesterase inhibitors and selective muscarinic receptor agonists in tests of reference and working memory.

    abstract::In recent years muscarinic receptor agonists and cholinesterase inhibitors have been developed for the treatment of Alzheimer's disease. We have evaluated examples from both classes of compounds in rodent tests of reference and working memory, as well as tests that are sensitive to the side-effects of these compounds....

    journal_title:Behavioural brain research

    pub_type: 杂志文章

    doi:10.1016/0166-4328(93)90130-i

    authors: Dawson GR,Iversen SD

    更新日期:1993-11-30 00:00:00

  • Retinal ganglion cells regenerating through the peripheral nerve graft retain their electroretinographic responses and mediate light-induced behavior.

    abstract::To assess the light-induced electrical activity of rodent retinal ganglion cells (RGCs) regenerating into a peripheral nerve (PN) graft we used non-invasive recording of electroretinographic responses to the contrast-reversal of sinusoidal gratings (p-ERG). On comparing the retinas that received a PN graft and retinas...

    journal_title:Behavioural brain research

    pub_type: 杂志文章

    doi:10.1016/s0166-4328(00)00184-4

    authors: Kittlerová P,Valousková V

    更新日期:2000-07-01 00:00:00

  • Alcohol enhances unprovoked 22-28 kHz USVs and suppresses USV mean frequency in High Alcohol Drinking (HAD-1) male rats.

    abstract::Heightened emotional states increase impulsive behaviors such as excessive ethanol consumption in humans. Though positive and negative affective states in rodents can be monitored in real-time through ultrasonic vocalization (USV) emissions, few animal studies have focused on the role of emotional status as a stimulus...

    journal_title:Behavioural brain research

    pub_type: 杂志文章

    doi:10.1016/j.bbr.2016.01.042

    authors: Thakore N,Reno JM,Gonzales RA,Schallert T,Bell RL,Maddox WT,Duvauchelle CL

    更新日期:2016-04-01 00:00:00

  • Hypobaric hypoxia induces dendritic plasticity in cortical and hippocampal pyramidal neurons in rat brain.

    abstract::Hypobaric hypoxia (HH), a predisposing environmental condition at high altitude (HA) encountered by many mountaineers jeopardizes their normal physiology like motor coordination and cognitive functions. Our previous studies revealed that the HH induces oxidative stress and neurodegeneration, which is associated with s...

    journal_title:Behavioural brain research

    pub_type: 杂志文章

    doi:10.1016/j.bbr.2008.01.007

    authors: Maiti P,Muthuraju S,Ilavazhagan G,Singh SB

    更新日期:2008-06-03 00:00:00

  • The effects of early exposure to MK-801 during environmental enrichment on spatial memory, methamphetamine self-administration and cue-induced renewal in rats.

    abstract:OBJECTIVE:Accumulating evidence indicates an association between improved cognition and the early introduction of environmental enrichment (EE). The beneficial effect of EE has also been examined in the field of methamphetamine (METH) dependence. The present study was designed to examine whether early cognitive alterat...

    journal_title:Behavioural brain research

    pub_type: 杂志文章

    doi:10.1016/j.bbr.2019.01.032

    authors: Zhang P,Pan J,Mao Z,Xu X,Lin D,Wu B,Zhou W,Liu Y

    更新日期:2019-05-02 00:00:00

  • Brain substrates of classical eyeblink conditioning: a highly localized but also distributed system.

    abstract::The rabbit classical nictitating membrane/eyeblink conditioning preparation has proven highly valuable for delineating neural structures and systems involved in associative learning. Research conducted over the last 20 years has revealed that the essential neural circuitry for acquisition and performance of this simpl...

    journal_title:Behavioural brain research

    pub_type: 杂志文章,评审

    doi:10.1016/s0166-4328(99)00181-3

    authors: Steinmetz JE

    更新日期:2000-06-01 00:00:00

  • Detection of PCC functional connectivity characteristics in resting-state fMRI in mild Alzheimer's disease.

    abstract::Resting-state networks dissociate in the early stage of Alzheimer's disease (AD). The posterior cingulate cortex (PCC) in AD brain is vulnerable to isolation from the rest of brain. However, it remains unclear how this functional connectivity is related to PCC changes. We employed resting-state functional MRI (fMRI) t...

    journal_title:Behavioural brain research

    pub_type: 杂志文章

    doi:10.1016/j.bbr.2008.08.012

    authors: Zhang HY,Wang SJ,Xing J,Liu B,Ma ZL,Yang M,Zhang ZJ,Teng GJ

    更新日期:2009-01-30 00:00:00

  • Sleep function(s) and cerebral metabolism.

    abstract::The function(s) of sleep would probably be better understood if the metabolic processes taking place within the central nervous system (CNS) during sleep were known in greater detail. The general pattern of the energy requirements of the brain during sleep is now outlined. Brain energy metabolism dramatically decrease...

    journal_title:Behavioural brain research

    pub_type: 杂志文章,评审

    doi:10.1016/0166-4328(95)00017-n

    authors: Maquet P

    更新日期:1995-07-01 00:00:00

  • Paw preference in dogs: relations between lateralised behaviour and immunity.

    abstract::Paw use in a task consisting of the removal of a piece of adhesive paper from the snout was investigated in 80 mongrel and pure-bred domestic dogs (Canis familiaris). Population lateralisation was observed, but in opposite directions in the two sexes (animals were not desexed): males preferentially used their left paw...

    journal_title:Behavioural brain research

    pub_type: 杂志文章

    doi:10.1016/j.bbr.2004.01.009

    authors: Quaranta A,Siniscalchi M,Frate A,Vallortigara G

    更新日期:2004-08-31 00:00:00

  • Training-stage related neuronal plasticity in limbic thalamus and cingulate cortex during learning: a possible key to mnemonic retrieval.

    abstract::This study is part of an ongoing project concerned with the analysis of the neural substrates of discriminative avoidance learning in rabbits. Multi-unit activity was recorded in 5 anterior and lateral thalamic nuclei and in 4 layers of 2 posterior cingulate cortical areas (29c/d and 29b) during learning. The rabbits ...

    journal_title:Behavioural brain research

    pub_type: 杂志文章

    doi:10.1016/s0166-4328(05)80111-1

    authors: Gabriel M,Vogt BA,Kubota Y,Poremba A,Kang E

    更新日期:1991-12-20 00:00:00

  • Is repeated exposure to immobilization needed to induce adaptation of the hypothalamic-pituitary-adrenal axis? Influence of adrenal factors.

    abstract::We have previously observed that a single exposure to a severe stressor such as immobilization in wooden boards (IMO) resulted in a faster return of plasma corticosterone (and to a lesser extent of ACTH) to basal activity when the rats were exposed again to the same stressor. In addition, the effect enhanced with time...

    journal_title:Behavioural brain research

    pub_type: 杂志文章

    doi:10.1016/s0166-4328(01)00340-0

    authors: Dal-Zotto S,Martí O,Armario A

    更新日期:2002-02-01 00:00:00

  • The right hemisphere is dominant in organization of visual search-A study in stroke patients.

    abstract::Cancellation tasks are widely used for diagnosis of lateralized attentional deficits in stroke patients. A disorganized fashion of target cancellation has been hypothesized to reflect disturbed spatial exploration. In the current study we aimed to examine which lesion locations result in disorganized visual search dur...

    journal_title:Behavioural brain research

    pub_type: 杂志文章

    doi:10.1016/j.bbr.2016.02.004

    authors: Ten Brink AF,Biesbroek JM,Kuijf HJ,Van der Stigchel S,Oort Q,Visser-Meily JM,Nijboer TC

    更新日期:2016-05-01 00:00:00

  • Alterations in cognitive function in prepubertal mice with protein malnutrition: relationship to changes in choline acetyltransferase.

    abstract::We have found that protein malnutrition (PM) causes a significant impairment of memory-related behavior on the 15th and 20th day after the start of PM (5% casein) feeding in prepubertal mice but not in postpubertal mice, as measured by a passive-avoidance task. This impairment was almost completely reversed by merely ...

    journal_title:Behavioural brain research

    pub_type: 杂志文章

    doi:10.1016/j.bbr.2005.08.024

    authors: Nakagawasai O,Yamadera F,Sato S,Taniguchi R,Hiraga H,Arai Y,Murakami H,Mawatari K,Niijima F,Tan-No K,Tadano T

    更新日期:2006-02-15 00:00:00

  • Intraventricular murine Aβ infusion elicits hippocampal inflammation and disrupts the consolidation, but not retrieval, of conditioned fear in C57BL6/J mice.

    abstract::Although one of the defining characteristics of Alzheimer's disease is the presence of amyloid-beta (Aβ) plaques, the early accumulation of soluble Aβ oligomers (AβOs) may disrupt synaptic function and trigger cognitive impairments long before the appearance of plaques. Furthermore, murine models aimed at understandin...

    journal_title:Behavioural brain research

    pub_type: 杂志文章

    doi:10.1016/j.bbr.2019.112303

    authors: White JD,Urbano CM,Taylor JO,Peterman JL,Cooksey M,Eimerbrink M,Eriksson MD,Cooper BG,Chumley MJ,Boehm GW

    更新日期:2020-01-27 00:00:00

  • Flupirtine attenuates chronic restraint stress-induced cognitive deficits and hippocampal apoptosis in male mice.

    abstract::Chronic restraint stress (CRS) causes hippocampal neurodegeneration and hippocampus-dependent cognitive deficits. Flupirtine represents neuroprotective effects and we have previously shown that flupirtine can protect against memory impairment induced by acute stress. The present study aimed to investigate whether flup...

    journal_title:Behavioural brain research

    pub_type: 杂志文章

    doi:10.1016/j.bbr.2015.04.004

    authors: Huang P,Li C,Fu T,Zhao D,Yi Z,Lu Q,Guo L,Xu X

    更新日期:2015-07-15 00:00:00

  • Non-effective increase of fMRI-activation for motor performance in elder individuals.

    abstract::Motor performance declines with increasing age and it has been proposed that elder people might compensate for these deficits with increased cerebral activation. However, it is not known, whether increased activation - especially in motor areas of the contralateral and the ipsilateral cerebral hemisphere - might effec...

    journal_title:Behavioural brain research

    pub_type: 杂志文章

    doi:10.1016/j.bbr.2011.04.040

    authors: Loibl M,Beutling W,Kaza E,Lotze M

    更新日期:2011-10-01 00:00:00

  • Overpressure blast injury-induced oxidative stress and neuroinflammation response in rat frontal cortex and cerebellum.

    abstract:BACKGROUND & AIM:Overpressure blast-wave induced brain injury (OBI) and its long-term neurological outcome pose significant concerns for military personnel. Our aim is to investigate the mechanism of injury due to OBI. METHODS:Rats were divided into 3 groups: (1) Control, (2) OBI (exposed 30psi peak pressure, 2-2.5ms)...

    journal_title:Behavioural brain research

    pub_type: 杂志文章

    doi:10.1016/j.bbr.2017.04.025

    authors: Toklu HZ,Yang Z,Oktay S,Sakarya Y,Kirichenko N,Matheny MK,Muller-Delp J,Strang K,Scarpace PJ,Wang KKW,Tümer N

    更新日期:2018-03-15 00:00:00

  • Unilateral lesions of the medial agranular cortex impair responding on a lateralised reaction time task.

    abstract::The present study assessed the behavioural sequalae of unilateral excitotoxic cortical lesions made either in the medial agranular cortex (AGm) or in the medial prefrontal cortex (mPFC) using a visual reaction time task. The task required animals to sustain a nose-poke in a central hole, until a brief light stimulus w...

    journal_title:Behavioural brain research

    pub_type: 杂志文章

    doi:10.1016/s0166-4328(00)00147-9

    authors: Brasted PJ,Dunnett SB,Robbins TW

    更新日期:2000-06-15 00:00:00

  • Roles of the pre-SMA and rIFG in conditional stopping revealed by transcranial magnetic stimulation.

    abstract::Although both the presupplementary motor area (pre-SMA) and the right inferior frontal gyrus (rIFG) have been demonstrated to be critical for response inhibition, there is still considerable disagreement over the roles they play in the process. In the present study, we investigated the causal relations of the pre-SMA ...

    journal_title:Behavioural brain research

    pub_type: 杂志文章

    doi:10.1016/j.bbr.2015.08.024

    authors: Lee HW,Lu MS,Chen CY,Muggleton NG,Hsu TY,Juan CH

    更新日期:2016-01-01 00:00:00

  • Animal model of autism using GSTM1 knockout mice and early post-natal sodium valproate treatment.

    abstract::Autism is a heterogeneous, behaviorally defined developmental disorder with unknown etiology but thought to be the result of environmental insult acting upon the developing brain of a genetically susceptible individual. Approximately 30% of individuals with autism have normal development up to the age of about 30 mont...

    journal_title:Behavioural brain research

    pub_type: 杂志文章

    doi:10.1016/j.bbr.2010.02.032

    authors: Yochum CL,Bhattacharya P,Patti L,Mirochnitchenko O,Wagner GC

    更新日期:2010-07-11 00:00:00

  • The study on the frontoparietal networks by continuous theta burst stimulation in healthy human subjects.

    abstract::Frontoparietal networks (FPNs) including the regions of the posterior parietal cortex (PPC) and dorsolateral prefrontal cortex (DLPFC) have been implicated in visuospatial attention. However, the functional interactions among different regions of dorsal FPNs remain elusive. The Attention Network Test (ANT) and continu...

    journal_title:Behavioural brain research

    pub_type: 杂志文章,随机对照试验

    doi:10.1016/j.bbr.2012.11.015

    authors: Xu G,Lan Y,Huang D,Chen S,Chen L,Zeng J,Pei Z

    更新日期:2013-03-01 00:00:00

  • Neural cell adhesion molecule (NCAM) null mice do not show a deficit in odour discrimination learning.

    abstract::Polysialylated neural cell adhesion molecule (PSA-NCAM) is predominantly expressed during development where it regulates biological functions including axon targeting and neuronal precursor cell migration. Although dramatically down regulated after birth in most regions of the nervous system, PSA-NCAM remains highly e...

    journal_title:Behavioural brain research

    pub_type: 杂志文章

    doi:10.1016/j.bbr.2003.10.011

    authors: Schellinck HM,Arnold A,Rafuse VF

    更新日期:2004-07-09 00:00:00

  • Renewal of extinguished behavior in pigeons (Columba livia) does not require memory consolidation of acquisition or extinction in a free-operant appetitive conditioning paradigm.

    abstract::Extinction learning is a fundamental capacity for adaptive and flexible behavior. As extinguished conditioned responding is prone to relapse under certain conditions, the necessity of memory consolidation for recovery phenomena to occur has been highlighted recently. Several studies have demonstrated that both acquisi...

    journal_title:Behavioural brain research

    pub_type: 杂志文章

    doi:10.1016/j.bbr.2019.111947

    authors: Packheiser J,Güntürkün O,Pusch R

    更新日期:2019-09-16 00:00:00

  • Postural performance in decerebrated rabbit.

    abstract::It is known that animals decerebrated at the premammillary level are capable of standing and walking without losing balance, in contrast to postmammillary ones which do not exhibit such behavior. The main goals of the present study were, first, to characterize the postural performance in premammillary rabbits, and, se...

    journal_title:Behavioural brain research

    pub_type: 杂志文章

    doi:10.1016/j.bbr.2008.02.011

    authors: Musienko PE,Zelenin PV,Lyalka VF,Orlovsky GN,Deliagina TG

    更新日期:2008-06-26 00:00:00

  • Repeated corticosterone injections in adult mice alter stress hormonal receptor expression in the cerebellum and motor coordination without affecting spatial learning.

    abstract::Receptors for glucocorticoid (GR) and corticotropin-releasing hormone (CRH) are largely found in brain sensorimotor structures, particularly in cerebellum, underlining a potential role of stress hormones in the regulation of motor function. Since CRH is involved in neuroplasticity, known for its trophic effect on syna...

    journal_title:Behavioural brain research

    pub_type: 杂志文章

    doi:10.1016/j.bbr.2017.02.035

    authors: Harlé G,Lalonde R,Fonte C,Ropars A,Frippiat JP,Strazielle C

    更新日期:2017-05-30 00:00:00