Abstract：
:Sleep deprivation impairs performance in emotional memory tasks, however this effect on memory is not completely understood. Possible mechanisms may involve an alteration in neurotransmission systems, as shown by the fact that many drugs that modulate neural pathways can prevent memory impairment by sleep loss. Gastrin releasing peptide (GRP) is a neuropeptide that emerged as a regulatory molecule of emotional memory through the modulation of other neurotransmission systems. Thus, the present study addressed the effect of intraperitoneal (IP) administration of bombesin (BB) (2.5, 5.0 and 10.0μg/kg), a GRP agonist, on the performance of Wistar rats in a multiple trail inhibitory avoidance (MTIA) task, after sleep deprivation, using the modified multiple platforms method (MMPM). Sleep deprived animals exhibited acquisition and retention impairment that was not prevented by BB injection. In addition, non-sleep deprived animals treated with BB before and after the training session, but not before the test, have shown a retention deficit. In summary, BB did not improve the memory impairment by sleep loss and, under normal conditions, produced a memory consolidation deficit.
journal_name
Behav Brain Resjournal_title
Behavioural brain researchauthors
Ferreira LBT,Oliveira SLB,Raya J,Esumi LA,Hipolide DCdoi
10.1016/j.bbr.2017.05.027subject
Has Abstractpub_date
2017-07-28 00:00:00pages
20-24eissn
0166-4328issn
1872-7549pii
S0166-4328(17)30250-4journal_volume
331pub_type
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