Abstract:
:Disruption of conditioned taste aversion (CTA) by tetrodotoxin (TTX) blockade of parabrachial nuclei elicited after ingestion of the gustatory CS and before administration of the visceral US is revealed by unchanged CS preference in retrieval test performed two days after acquisition. The universality of the above amnesia was examined in rats. In Experiment 1, parabrachial TTX disrupted CTAs when sodium saccharin (0.1%), quinine hydrochloride (0.0072%), sodium chloride (0.9%) or a garlic extract were used as the CS and i.p. LiCl (0.15 M, 2% body weight) as the US. In Experiment 2, parabrachial TTX disrupted CTAs when 0.9% NaCl was used as the CS and i.p. injection of LiCl (0.15 M, 2% body weight), D-amphetamine (3 mg/kg) or carbachol (0.15 mg/kg) served as the US. Experiment 3 showed that post-drinking parabrachial TTX blocked also CTA induced by LiCl drinking, i.e. under conditions of CS-US identity. Experiments 4 and 5 demonstrated that the amnesia is not confounded by TTX-induced reduction of fluid intake because the CTA disruption was well expressed even when tested after recovery of normal fluid intake 3 days after TTX injection and in animals receiving 12 days of preacquisition adaptation to limited fluid access. It is concluded that parabrachial nuclei represent an important point of convergence for various classes of CTA eliciting stimuli.
journal_name
Behav Brain Resjournal_title
Behavioural brain researchauthors
Bielavska E,Bures Jdoi
10.1016/0166-4328(94)90060-4subject
Has Abstractpub_date
1994-01-31 00:00:00pages
35-42issue
1eissn
0166-4328issn
1872-7549pii
0166-4328(94)90060-4journal_volume
60pub_type
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