Abstract：
:Administration of Triazolam (Tz)--a short acting benzodiazepine (BZ)--induces permanent phase-shifts in locomotor activity of golden hamsters (Mesocricetus auratus). However, the target area(s) as well as the mechanism involved in the Tz-induced changes are not known. Previous results indicated that raphe nuclei (RN) would appear to be a likely site for Tz-induced phase shifts. Therefore, we specifically destroyed the 5-HT fibers connecting the RN with the SCN--the site of the endogenous mammalian clock--by microinjections of the selective neurotoxin 5,7 dihydroxytryptamine (5,7-DHT) at the level of SCN. Infusion of 5,7-DHT resulted in long lasting damage of the ascending serotonergic projection from RN to the hypothalamus. Subsequently, the phase-shifting effect of Tz was investigated. Only complete or almost complete depletion of the 5-HT input to the SCN was accompanied with a pronounced reduction of the phase shift together with a significant reduction of wheel-running activity during the 6 h following Tz injection. Our present results support the view that the 5-HT innervation of the SCN represents an essential link in the phase-shifting action following peripheral Tz injections.
journal_name
Behav Brain Resjournal_title
Behavioural brain researchauthors
Cutrera RA,Kalsbeek A,Pévet Pdoi
10.1016/0166-4328(94)90034-5subject
Has Abstractpub_date
1994-05-30 00:00:00pages
21-8issue
1eissn
0166-4328issn
1872-7549pii
0166-4328(94)90034-5journal_volume
62pub_type
杂志文章abstract：:The present experiment was designed to examine the effects of prenatal stress and gender in latent inhibition. Prenatal stress has been proposed as a risk factor both for depression and for schizophrenia, and both of these syndromes are associated with alterations in the functional state of the dopamine system. There ...
journal_title：Behavioural brain research
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journal_title：Behavioural brain research
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journal_title：Behavioural brain research
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pub_type： 杂志文章
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journal_title：Behavioural brain research
pub_type： 杂志文章
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journal_title：Behavioural brain research
pub_type： 杂志文章
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journal_title：Behavioural brain research
pub_type： 杂志文章
doi：10.1016/s0166-4328(99)00070-4
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journal_title：Behavioural brain research
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更新日期：2015-01-01 00:00:00
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journal_title：Behavioural brain research
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journal_title：Behavioural brain research
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更新日期：2011-03-17 00:00:00
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journal_title：Behavioural brain research
pub_type： 杂志文章
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更新日期：2002-11-15 00:00:00
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journal_title：Behavioural brain research
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更新日期：2013-08-01 00:00:00
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pub_type： 杂志文章
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journal_title：Behavioural brain research
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更新日期：2014-11-01 00:00:00
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journal_title：Behavioural brain research
pub_type： 杂志文章
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