Abstract：
:Rats were trained in a two-way active avoidance task followed immediately by a lateral hypothalamic intracranial self-stimulation (ICSS) treatment, during 5 consecutive days. The effects of the number of ICSS trains allowed (0, 500, 2500 or 4500) were studied upon acquisition and long-term retention (LTR, 10 and 30 days). The number of ICSS trains administered and the number of avoidances at the last acquisition session (5th) showed a positive lineal relation, that is, the more number of ICSS trains, the more number of avoidances. The level of learning achieved during the 5th session was maintained after the LTR periods in all experimental groups. It is concluded that the number of ICSS trains could be a critical parameter in the facilitatory effect of lateral hypothalamic ICSS upon learning, and it is suggested that the facilitatory effect of post-training lateral hypothalamic ICSS might be due to the activation of general activatory neural systems.
journal_name
Behav Brain Resjournal_title
Behavioural brain researchauthors
Segura-Torres P,Portell-Cortés I,Morgado-Bernal Idoi
10.1016/s0166-4328(05)80007-5subject
Has Abstractpub_date
1991-02-28 00:00:00pages
161-7issue
2eissn
0166-4328issn
1872-7549pii
S0166-4328(05)80007-5journal_volume
42pub_type
杂志文章abstract：:The present study investigated the effects of a single intravenous (i.v.) dose of Vitamin C (ascorbate, ASC) on spatial memory in APP/PSEN1 mice, an Alzheimer's disease model. First, we confirmed the uptake time course in ASC-depleted gulo (-/-) mice, which cannot synthesize ASC. Differential tissue uptake was seen ba...
journal_title：Behavioural brain research
pub_type： 杂志文章
doi：10.1016/j.bbr.2014.01.044
更新日期：2014-05-01 00:00:00
abstract：:Explicit encoding requires humans to select the information relevant to their goals, yet not all irrelevant information is discarded. The present study addressed how different quantity and relevance of information modulate the electrophysiological activity during the encoding and retrieval phases of a recognition memo...
journal_title：Behavioural brain research
pub_type： 杂志文章
doi：10.1016/j.bbr.2012.11.041
更新日期：2013-03-15 00:00:00
abstract：:Taste recognition memory in rodents is evident as taste neophobia disappears upon repeated taste exposures without aversive consequences, thus increasing the consumption of familiar edibles. The attenuation of taste neophobia (AN) induced by taste familiarity is auditory context-dependent in mice since neophobia to a ...
journal_title：Behavioural brain research
pub_type： 杂志文章
doi：10.1016/j.bbr.2020.112687
更新日期：2020-08-05 00:00:00
abstract：:The performance of subjects walking blindly to previously inspected visual targets (located at 5, 10 or 15 m from the subjects) was studied in 2 experiments. In Expt. 1, subjects selected as good visual imagers were instructed to build up a mental representation of the target. Then they had to either actually walk or ...
journal_title：Behavioural brain research
pub_type： 杂志文章
doi：10.1016/s0166-4328(89)80088-9
更新日期：1989-08-01 00:00:00
abstract：:The neurophysiology of human associative memory has been studied with electroencephalographic techniques since the 1930s. This research has revealed that different types of electrophysiological processes in the human brain can be modified by conditioning: sensory evoked potentials, sensory induced gamma-band activity,...
journal_title：Behavioural brain research
pub_type： 杂志文章,评审
doi：10.1016/j.bbr.2015.09.011
更新日期：2016-01-01 00:00:00
abstract：:The endogenous opioid system is involved in ethanol reinforcement. Ethanol-induced changes in opioidergic transmission have been extensively studied in adult organisms. However, the impact of ethanol exposure at low or moderate doses during early ontogeny has been barely explored. We investigated the effect of prenata...
journal_title：Behavioural brain research
pub_type： 杂志文章
doi：10.1016/j.bbr.2014.08.022
更新日期：2014-11-01 00:00:00
abstract：:Administration of Triazolam (Tz)--a short acting benzodiazepine (BZ)--induces permanent phase-shifts in locomotor activity of golden hamsters (Mesocricetus auratus). However, the target area(s) as well as the mechanism involved in the Tz-induced changes are not known. Previous results indicated that raphe nuclei (RN) ...
journal_title：Behavioural brain research
pub_type： 杂志文章
doi：10.1016/0166-4328(94)90034-5
更新日期：1994-05-30 00:00:00
abstract：:Clinical research has identified developmental delay and physical malformations in children prenatally exposed to the antiepileptic drug (AED) valproic acid (VPA). However, the early signs of neurodevelopmental deficits, their evolution during postnatal development and growth, and the dose effects of VPA are not well ...
journal_title：Behavioural brain research
pub_type： 杂志文章
doi：10.1016/j.bbr.2016.05.023
更新日期：2016-09-15 00:00:00
abstract：:Prolonged and sustained stimulation of the hypothalamo-pituitary-adrenal axis have adverse effects on numerous brain regions, including the cerebellum. Motor coordination and motor learning are essential for animal and require the regulation of cerebellar neurons. The G-protein-coupled cannabinoid CB1 receptor coordin...
journal_title：Behavioural brain research
pub_type： 杂志文章
doi：10.1016/j.bbr.2016.01.036
更新日期：2016-04-15 00:00:00
abstract：:Research into object recognition memory has been galvanised by the introduction of spontaneous preference tests for rodents. The standard task, however, contains a number of inherent shortcomings that reduce its power. Particular issues include the problem that individual trials are time consuming, so limiting the tot...
journal_title：Behavioural brain research
pub_type： 杂志文章,评审
doi：10.1016/j.bbr.2014.07.049
更新日期：2015-05-15 00:00:00
abstract：:The study examined the relationship between risk-taking behavior during selection of monetary rewards and activations in the anterior cingulate cortex (ACC), orbitofrontal cortex (OFC) and medial prefrontal cortex (mPFC), brain regions that are associated with decision-making. Thirty-three adolescents with no personal...
journal_title：Behavioural brain research
pub_type： 杂志文章
doi：10.1016/j.bbr.2010.09.033
更新日期：2011-02-02 00:00:00
abstract：:Neuromedin U (NmU) is a widely distributed and multifunctional peptide in the central nervous system and the peripheral tissues. Little is know about the mechanisms of NmU on brain functions. The rodent isoform of the NmU, NmU-23, has been shown to have anxiolytic effects involved in the β-adrenergic and cholinergic n...
journal_title：Behavioural brain research
pub_type： 杂志文章
doi：10.1016/j.bbr.2013.11.005
更新日期：2014-02-01 00:00:00
abstract：:Mild traumatic brain injury (mTBI), caused by an insult to the head, results in a cascade of molecular imbalance that includes altered glucose metabolism, mitochondrial dysfunction, and increases in reactive oxygen species. Although glucose is the primary energy source for the brain, it becomes an inefficient substrat...
journal_title：Behavioural brain research
pub_type： 杂志文章
doi：10.1016/j.bbr.2019.112225
更新日期：2019-12-30 00:00:00
abstract：:Adolescents are more likely than adults to develop chronic symptoms, such as impulsivity and difficulty concentrating, following a mild traumatic brain injury (mTBI) which may relate to disruption of pre-frontal cortex (PFC development). During adolescence the PFC is undergoing extensive remodelling, driving maturatio...
journal_title：Behavioural brain research
pub_type： 杂志文章
doi：10.1016/j.bbr.2020.113067
更新日期：2020-12-14 00:00:00
abstract：:Women are more susceptible than men to develop anxiety disorders, however, the mechanisms involved are still unclear. In this study, we investigated the role of group I metabotropic glutamate receptors (mGluRs), a target for anxiety disorders, and whether estradiol may modulate conflict-based anxiety in female rats by...
journal_title：Behavioural brain research
pub_type： 杂志文章
doi：10.1016/j.bbr.2016.01.009
更新日期：2016-04-01 00:00:00
abstract：:Catechol-O-methyltransferase, an enzyme involved in regulating brain catecholamine levels, has been implicated in anxiety, pain and/or stress responsivity. Elements of this putative association remain unclarified, notably whether: (a) COMT variation modulates responses to acute and/or chronic stress equally; (b) acute...
journal_title：Behavioural brain research
pub_type： 杂志文章
doi：10.1016/j.bbr.2011.12.014
更新日期：2012-03-17 00:00:00
abstract：:We evaluated repeated exposures of mice to a trained aggressor mouse as a model (adapted from "social stress" models of traumatic stress) for aspects of post-traumatic stress disorder (PTSD). Using a "cage-within-cage resident-intruder" protocol, subject C57BL/6J mice were exposed to aggressors for 6 h daily for 5 or ...
journal_title：Behavioural brain research
pub_type： 杂志文章
doi：10.1016/j.bbr.2012.07.022
更新日期：2012-11-01 00:00:00
abstract：:The prefrontal cortex (PFC) is known to be involved in associative learning; however, its specific role in acquisition of cued classical conditioning has not yet been determined. Furthermore, the role of regional differences within the PFC in the acquisition of cued conditioning is not well described. These issues wer...
journal_title：Behavioural brain research
pub_type： 杂志文章
doi：10.1016/j.bbr.2003.09.014
更新日期：2003-11-30 00:00:00
abstract：:Oxytocin is an important messenger in the brain that has been linked to a variety of social functions in pharmacological studies. Besides, functional genetic variations on the oxytocin receptor gene have been repeatedly associated with social processing and functioning. Despite this knowledge, there are very few studi...
journal_title：Behavioural brain research
pub_type： 杂志文章
doi：10.1016/j.bbr.2017.04.036
更新日期：2017-06-30 00:00:00
abstract：:At present neurobiological interests are directing more attention towards the major role of the amygdalar GABA(A) receptor on orexin-dependent behaviors. This telencephalic region has been widely studied especially in view of its control on various psychiatric disorders such as anxiety and depression. Recently, cross-...
journal_title：Behavioural brain research
pub_type： 杂志文章
doi：10.1016/j.bbr.2010.11.014
更新日期：2011-04-15 00:00:00
abstract：:The aim of this study was to trace by molecular imaging techniques the neural substrates of attention deficit hyperactivity disorder (ADHD) using the spontaneously hypertensive rat (SHR) as animal model. Adult SHR and Wistar-Kyoto (WKY) controls were used throughout this study. In experiment 1, naive male SHR and WKY ...
journal_title：Behavioural brain research
pub_type： 杂志文章
doi：10.1016/s0166-4328(97)00180-0
更新日期：1998-07-01 00:00:00
abstract：:In order to automate a simultaneous visual discrimination system, a Sutherland jumping-stand box was modified by adding two lateral alleys which connect the feeder compartment with the starting box. By means of a digital interface, this modified box was connected to an Apple IIe PC. A group of rats (n = 8) was trained...
journal_title：Behavioural brain research
pub_type： 杂志文章
doi：10.1016/s0166-4328(05)80126-3
更新日期：1992-04-10 00:00:00
abstract：:The aim of study was to search for new biomarkers with a magnetic resonance technique to identify the early stages of dementia, induced by D-galactose, and evaluate Simvastatin therapy. Localized proton magnetic resonance spectroscopy measurements showed a significant decrease in the concentration of N-acetylaspartate...
journal_title：Behavioural brain research
pub_type： 杂志文章
doi：10.1016/j.bbr.2015.02.016
更新日期：2015-05-01 00:00:00
abstract：:Voice disorders manifest in the early stages of Parkinson disease (PD), suggesting the vulnerability of the laryngeal sensorimotor system to mild alterations in dopamine signaling. Previous research has demonstrated that manipulations of central dopamine result in acoustic changes in rat ultrasonic vocalization (USV) ...
journal_title：Behavioural brain research
pub_type： 杂志文章
doi：10.1016/j.bbr.2013.06.006
更新日期：2013-09-01 00:00:00
abstract：:Sleep deprivation induces oxidative stress and impairs learning and memory processes. Vitamin E, on the other hand, is a strong antioxidant that has neuroprotective effect on the brain. In this study, we examined the potential protective effect of chronic administration of vitamin E on chronic sleep deprivation-induce...
journal_title：Behavioural brain research
pub_type： 杂志文章
doi：10.1016/j.bbr.2011.09.017
更新日期：2012-01-01 00:00:00
abstract：:This study compared repeated treatment with methamphetamine (4.0 mg/kg, i.p.) plus scopolamine (0.5 mg/kg, i.p.) and methamphetamine alone in behavioral sensitization and drug conditioning with respect to a reciprocal balance between the dopaminergic and cholinergic systems. Repeated methamphetamine plus scopolamine t...
journal_title：Behavioural brain research
pub_type： 杂志文章
doi：10.1016/0166-4328(96)00032-0
更新日期：1996-10-01 00:00:00
abstract：:Neuroendocrinology of chronic stress seems to be characterized by HPA axis hyperactivity and early childhood stressors have been hypothesized to predispose individuals to adult onset depression by means of dysregulation of the HPA axis. Pivagabine (PVG), a hydrophobic 4-aminobutyric acid derivative, has been used expe...
journal_title：Behavioural brain research
pub_type： 临床试验,杂志文章,随机对照试验
doi：10.1016/s0166-4328(01)00177-2
更新日期：2001-07-01 00:00:00
abstract：BACKGROUND:As an atypical antipsychotic drug, quetiapine had been approved for bipolar disorder and for adjunctive therapy in major depressive disorder and schizophrenia. Recently quetiapine has been suggested to be a promising pharmacotherapy for alcohol dependence. This study was performed to determine the effects of...
journal_title：Behavioural brain research
pub_type： 杂志文章
doi：10.1016/j.bbr.2020.112561
更新日期：2020-05-15 00:00:00
abstract：:Gangliosides are compounds that are abundant throughout the CNS, participating actively in neuroplasticity. We previously described that exogenous GM1 ganglioside pretreatment enhances the rewarding properties of cocaine, evidenced by a lower number of sessions and/or dosage necessary to induce conditioned place prefe...
journal_title：Behavioural brain research
pub_type： 杂志文章
doi：10.1016/j.bbr.2014.10.013
更新日期：2015-02-01 00:00:00
abstract：:Depression is the most common psychiatric comorbidity to be diagnosed following traumatic brain injury (TBI). In clinical populations, TBI-induced depression may be particularly difficult to treat due to both unique underlying causes and the propensity for treatment resistance. Preclinical assays are needed to charact...
journal_title：Behavioural brain research
pub_type： 杂志文章
doi：10.1016/j.bbr.2020.112879
更新日期：2020-10-01 00:00:00
