Abstract：
:Prolonged and sustained stimulation of the hypothalamo-pituitary-adrenal axis have adverse effects on numerous brain regions, including the cerebellum. Motor coordination and motor learning are essential for animal and require the regulation of cerebellar neurons. The G-protein-coupled cannabinoid CB1 receptor coordinates synaptic transmission throughout the CNS and is of highest abundance in the cerebellum. Accordingly, the aim of this study was to investigate the long-lasting effects of chronic psychosocial stress on motor coordination and motor learning, CB1 receptor expression, endogenous cannabinoid ligands and gene expression in the cerebellum. After chronic psychosocial stress, motor coordination and motor learning were impaired as indicated the righting reflex and the rota-rod. The amount of the endocannabinoid 2-AG increased while CB1 mRNA and protein expression were downregulated after chronic stress. Transcriptome analysis revealed 319 genes differentially expressed by chronic psychosocial stress in the cerebellum; mainly involved in synaptic transmission, transmission of nerve impulse, and cell-cell signaling. Calreticulin was validated as a stress candidate gene. The present study provides evidence that chronic stress activates calreticulin and might be one of the pathological mechanisms underlying the motor coordination and motor learning dysfunctions seen in social defeat mice.
journal_name
Behav Brain Resjournal_title
Behavioural brain researchauthors
Tomas-Roig J,Piscitelli F,Gil V,Del Río JA,Moore TP,Agbemenyah H,Salinas-Riester G,Pommerenke C,Lorenzen S,Beißbarth T,Hoyer-Fender S,Di Marzo V,Havemann-Reinecke Udoi
10.1016/j.bbr.2016.01.036subject
Has Abstractpub_date
2016-04-15 00:00:00pages
34-43eissn
0166-4328issn
1872-7549pii
S0166-4328(16)30032-8journal_volume
303pub_type
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