Abstract:
:Three experiments compared the effects of dopamine depletion from the caudate-putamen (CAUD; dorsal striatum) or nucleus accumbens septi (NAS; ventral striatum), or a systemically administered dopamine receptor antagonist (alpha-flupenthixol) on the acquisition and performance of a conditional discrimination task involving temporal frequency. In Expt. 1, rats receiving 6-hydroxydopamine (6-OHDA) lesions of the CAUD were impaired in the acquisition of a visual version of the task, and rats with 6-OHDA lesions of the NAS were not reliably impaired. Even when the rats with CAUD lesions had acquired the discrimination, they were still significantly slower to collect earned food pellets. Both CAUD and NAS lesions reduced a bias to respond to the faster of the two discriminative stimuli. In Expt. 2, rats with 6-OHDA lesions of CAUD were markedly impaired in their accuracy and speed of responding when they had been trained to criterion preoperatively. These effects could not be mimicked in controls by prefeeding (which had only minor effects on performance). Rats with 6-OHDA-induced lesions of the NAS were unimpaired in either visual or auditory discrimination performance, but were slower to extinguish responding than controls. In Expt. 3, alpha-flupenthixol (0.1-0.56 mg/kg, i.p.) produced dose-dependent impairments in both latency to respond and choice accuracy in visual and auditory versions of the task. In conjunction with other results, these data suggest that (1) dopamine receptor blockade and central dopamine depletion can impair discrimination performance under certain conditions (2) dopamine depletion from the ventral and dorsal striatum, respectively, have dissociable effects on behaviour controlled by conditioned reinforcers and discriminative stimuli and (3) the disruption of discrimination performance by dorsal striatal dopamine depletion is probably attributable to several factors.
journal_name
Behav Brain Resjournal_title
Behavioural brain researchauthors
Robbins TW,Giardini V,Jones GH,Reading P,Sahakian BJdoi
10.1016/0166-4328(90)90179-isubject
Has Abstractpub_date
1990-05-28 00:00:00pages
243-61issue
3eissn
0166-4328issn
1872-7549pii
0166-4328(90)90179-Ijournal_volume
38pub_type
杂志文章abstract::The ability of the somatosensory cortex in differentiating various tactile sensations is very important for a person to perceive the surrounding environment. In this study, we utilize a lab-made multi-channel functional near-infrared spectroscopy (fNIRS) to discriminate the hemodynamic responses (HRs) of four differen...
journal_title:Behavioural brain research
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更新日期:2017-08-30 00:00:00
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journal_title:Behavioural brain research
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journal_title:Behavioural brain research
pub_type: 杂志文章
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journal_title:Behavioural brain research
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journal_title:Behavioural brain research
pub_type: 杂志文章
doi:10.1016/0166-4328(88)90082-4
更新日期:1988-04-01 00:00:00
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journal_title:Behavioural brain research
pub_type: 杂志文章,评审
doi:10.1016/0166-4328(94)00116-w
更新日期:1995-01-23 00:00:00
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journal_title:Behavioural brain research
pub_type: 杂志文章
doi:10.1016/j.bbr.2017.08.036
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journal_title:Behavioural brain research
pub_type: 杂志文章
doi:10.1016/0166-4328(90)90059-n
更新日期:1990-01-22 00:00:00
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journal_title:Behavioural brain research
pub_type: 杂志文章
doi:10.1016/j.bbr.2019.02.041
更新日期:2019-05-17 00:00:00
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journal_title:Behavioural brain research
pub_type: 杂志文章
doi:10.1016/j.bbr.2020.112561
更新日期:2020-05-15 00:00:00
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journal_title:Behavioural brain research
pub_type: 杂志文章
doi:10.1016/s0166-4328(01)00460-0
更新日期:2002-08-21 00:00:00
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journal_title:Behavioural brain research
pub_type: 杂志文章
doi:10.1016/j.bbr.2020.112687
更新日期:2020-08-05 00:00:00
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journal_title:Behavioural brain research
pub_type: 杂志文章
doi:10.1016/s0166-4328(89)80102-0
更新日期:1989-09-01 00:00:00
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journal_title:Behavioural brain research
pub_type: 杂志文章
doi:10.1016/j.bbr.2017.08.022
更新日期:2017-09-29 00:00:00
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journal_title:Behavioural brain research
pub_type: 杂志文章
doi:10.1016/j.bbr.2016.11.037
更新日期:2017-03-01 00:00:00
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journal_title:Behavioural brain research
pub_type: 杂志文章
doi:10.1016/s0166-4328(89)80002-6
更新日期:1989-10-01 00:00:00
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journal_title:Behavioural brain research
pub_type: 杂志文章,评审
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更新日期:2002-03-10 00:00:00
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journal_title:Behavioural brain research
pub_type: 杂志文章
doi:10.1016/0166-4328(85)90030-0
更新日期:1985-12-01 00:00:00
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doi:10.1016/j.bbr.2016.11.035
更新日期:2017-03-01 00:00:00
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journal_title:Behavioural brain research
pub_type: 杂志文章
doi:10.1016/j.bbr.2013.08.020
更新日期:2013-11-01 00:00:00
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journal_title:Behavioural brain research
pub_type: 杂志文章
doi:10.1016/j.bbr.2018.04.054
更新日期:2018-09-03 00:00:00
abstract::This study was aimed at determining whether granule cell degeneration induced by intragyral injections of a neutral fluid (0.9% NaCl with 0.6% glucose, pH 7.0, 2 sites per hippocampus, 2 microliters/site, 1 microliter/min) produced behavioural deficits in rats which, 2 weeks prior to the injections had received either...
journal_title:Behavioural brain research
pub_type: 杂志文章
doi:10.1016/0166-4328(94)90088-4
更新日期:1994-08-31 00:00:00
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journal_title:Behavioural brain research
pub_type: 杂志文章
doi:10.1016/j.bbr.2016.01.007
更新日期:2016-04-01 00:00:00
abstract::The present study has been designed to investigate the effect of amniotic fluid derived stem cells on focal cerebral ischaemia-reperfusion injury induced behavioural deficits in mice. Middle cerebral artery occlusion of 60 min followed by reperfusion for 7 days was employed in present study to produce ischaemia and re...
journal_title:Behavioural brain research
pub_type: 杂志文章
doi:10.1016/j.bbr.2007.05.028
更新日期:2007-10-01 00:00:00
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journal_title:Behavioural brain research
pub_type: 杂志文章
doi:10.1016/j.bbr.2016.11.046
更新日期:2017-03-01 00:00:00
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journal_title:Behavioural brain research
pub_type: 杂志文章
doi:10.1016/j.bbr.2007.07.030
更新日期:2008-01-10 00:00:00
abstract::Catechol-O-methyltransferase, an enzyme involved in regulating brain catecholamine levels, has been implicated in anxiety, pain and/or stress responsivity. Elements of this putative association remain unclarified, notably whether: (a) COMT variation modulates responses to acute and/or chronic stress equally; (b) acute...
journal_title:Behavioural brain research
pub_type: 杂志文章
doi:10.1016/j.bbr.2011.12.014
更新日期:2012-03-17 00:00:00
abstract::The area postrema (AP), a chemosensitive organ located in the fourth ventricle, has been shown to mediate the formation of a lithium-induced conditioned taste avoidance (CTA) in rats. The present experiments examined the role of the AP in the discrimination between two equimolar solutions of sodium chloride (NaCl) and...
journal_title:Behavioural brain research
pub_type: 杂志文章
doi:10.1016/s0166-4328(97)02279-1
更新日期:1997-08-01 00:00:00