Abstract:
:Circadian rhythms are regulated by clock proteins through post-translational modifications. Indeed, Casein kinase I epsilon (CKIvarepsilon) promotes reversible phosphorylation of PER proteins, and a deficiency in this phosphorylation has been implicated in human sleep disorders. Here, we investigated the CKIvarepsilon S408N polymorphism in a Brazilian population sample. The N408 allele was previously described to be much less frequent in individuals with Delayed Sleep-Phase Syndrome (DSPS), than in the general Japanese population, suggesting a protective function for the allele against the disease. We found that this polymorphism is very rare in the Brazilian population (1.37%), indicating that it has no influence on susceptibility to circadian rhythm sleep disorders. Therefore, it is necessary to account for adaptative influences in genetic background, analyzing different groups with different photoperiods, to validate the effects of this and other polymorphisms on sleep and circadian disorders.
journal_name
Behav Brain Resjournal_title
Behavioural brain researchauthors
Castro RM,Barbosa AA,Pedrazzoli M,Tufik Sdoi
10.1016/j.bbr.2008.05.005subject
Has Abstractpub_date
2008-11-03 00:00:00pages
156-7issue
1eissn
0166-4328issn
1872-7549pii
S0166-4328(08)00259-3journal_volume
193pub_type
杂志文章abstract::Previous research in humans and animals suggests that prior exposure to stress alters responsivity to drugs of abuse, including psychostimulants. Male rats show an augmented striatal dopamine response to methamphetamine following exposure to chronic unpredictable stress (CUS). Compared to males, female rats have been ...
journal_title:Behavioural brain research
pub_type: 杂志文章
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更新日期:2019-12-30 00:00:00
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journal_title:Behavioural brain research
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journal_title:Behavioural brain research
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更新日期:2019-04-01 00:00:00
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journal_title:Behavioural brain research
pub_type: 杂志文章
doi:10.1016/j.bbr.2016.01.007
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journal_title:Behavioural brain research
pub_type: 杂志文章
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更新日期:2009-12-28 00:00:00
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journal_title:Behavioural brain research
pub_type: 杂志文章
doi:10.1016/j.bbr.2005.10.016
更新日期:2006-03-15 00:00:00
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journal_title:Behavioural brain research
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更新日期:2019-08-05 00:00:00
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journal_title:Behavioural brain research
pub_type: 杂志文章
doi:10.1016/j.bbr.2003.11.012
更新日期:2004-08-12 00:00:00
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journal_title:Behavioural brain research
pub_type: 杂志文章
doi:10.1016/j.bbr.2012.05.027
更新日期:2012-08-01 00:00:00
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journal_title:Behavioural brain research
pub_type: 杂志文章
doi:10.1016/j.bbr.2019.03.026
更新日期:2019-07-02 00:00:00
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journal_title:Behavioural brain research
pub_type: 杂志文章
doi:10.1016/j.bbr.2004.02.012
更新日期:2004-09-23 00:00:00
abstract::Substantial evidence from preclinical models of pain suggests that basal and noxious nociceptive sensitivity, as well as antinociceptive responses to drugs, show significant heritability. Individual differences to these responses have been observed across species from rodents to humans. The use of closely related C57B...
journal_title:Behavioural brain research
pub_type: 杂志文章
doi:10.1016/j.bbr.2020.112698
更新日期:2020-07-15 00:00:00
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journal_title:Behavioural brain research
pub_type: 杂志文章
doi:10.1016/s0166-4328(97)00121-6
更新日期:1998-03-01 00:00:00
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journal_title:Behavioural brain research
pub_type: 杂志文章
doi:10.1016/j.bbr.2015.03.018
更新日期:2015-01-01 00:00:00
abstract::Alterations in default mode network (DMN) functional connectivity (FC) might accompany the dysfunction of Alzheimer's disease (AD). Indeed, episodic memory impairment is a hallmark of AD, and mild cognitive impairment (MCI) has been associated with a high risk for AD. Phosphatidylinositol-binding clathrin assembly pro...
journal_title:Behavioural brain research
pub_type: 杂志文章
doi:10.1016/j.bbr.2017.05.043
更新日期:2017-07-28 00:00:00
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journal_title:Behavioural brain research
pub_type: 杂志文章
doi:10.1016/j.bbr.2007.06.003
更新日期:2007-11-02 00:00:00
abstract::Hepatic encephalopathy (HE) is a complex neuropsychiatric syndrome resulting from acute or chronic hepatic impairments. The clinical features of HE include attention as well as a mild cognitive deficits associated with impaired attentional and executive networks in patients as well as in animal models of HE. The under...
journal_title:Behavioural brain research
pub_type: 杂志文章
doi:10.1016/j.bbr.2019.03.046
更新日期:2019-07-23 00:00:00
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journal_title:Behavioural brain research
pub_type: 杂志文章
doi:10.1016/s0166-4328(01)00324-2
更新日期:2002-02-01 00:00:00
abstract::Animal (monkey, rat, mouse) models are widely used to investigate degenerative processes and potential therapeutic treatments for human Parkinson's disease (PD). One task that has proved useful in these investigations is a reach-to-grasp task (skilled reaching) in which an animal reaches for a piece of food that it th...
journal_title:Behavioural brain research
pub_type: 临床试验,杂志文章
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更新日期:2002-07-18 00:00:00
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journal_title:Behavioural brain research
pub_type: 杂志文章
doi:10.1016/j.bbr.2014.03.019
更新日期:2014-07-01 00:00:00
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journal_title:Behavioural brain research
pub_type: 杂志文章
doi:10.1016/j.bbr.2017.03.015
更新日期:2017-05-30 00:00:00
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journal_title:Behavioural brain research
pub_type: 杂志文章
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更新日期:2020-09-01 00:00:00
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journal_title:Behavioural brain research
pub_type: 杂志文章
doi:10.1016/s0166-4328(99)00046-7
更新日期:1999-10-01 00:00:00
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journal_title:Behavioural brain research
pub_type: 杂志文章
doi:10.1016/j.bbr.2018.09.007
更新日期:2019-01-01 00:00:00
abstract::Nicotine replacement treatments are being alternatively applied as an aid to smoking cessation during pregnancy. However, the effects of nicotine exposed at the prenatal stage on the emotional behaviors in offspring are not well understood due to the lack of systematic investigations. The current study has therefore i...
journal_title:Behavioural brain research
pub_type: 杂志文章
doi:10.1016/j.bbr.2012.10.058
更新日期:2013-02-15 00:00:00
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journal_title:Behavioural brain research
pub_type: 杂志文章,评审
doi:10.1016/j.bbr.2008.12.005
更新日期:2009-05-16 00:00:00
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journal_title:Behavioural brain research
pub_type: 杂志文章
doi:10.1016/0166-4328(90)90030-i
更新日期:1990-08-20 00:00:00
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journal_title:Behavioural brain research
pub_type: 杂志文章
doi:10.1016/0166-4328(80)90024-8
更新日期:1980-08-01 00:00:00
abstract::Previous research has shown that children living in clandestine methamphetamine (MA) labs are passively exposed to the drug [1]. The long-term effects of this early exposure on the dopaminergic systems are unknown, but may be important for adult behaviors mediated by dopamine, such as drug addiction. The current study...
journal_title:Behavioural brain research
pub_type: 杂志文章
doi:10.1016/j.bbr.2012.01.013
更新日期:2012-04-01 00:00:00
abstract::The effects of 6-hydroxydopamine-induced depletion of forebrain noradrenaline (NA) on oral intake of ethanol were studied in male Wistar rats. Prior depletion of NA produced a smaller and significantly less variable intake of a concentrated solution of ethanol than that of control rats, and this effect was not accompa...
journal_title:Behavioural brain research
pub_type: 杂志文章
doi:10.1016/0166-4328(83)90168-7
更新日期:1983-04-01 00:00:00