Abstract:
:Women are at greater risk than men for developing posttraumatic stress disorder (PTSD) after trauma exposure. Sleep, especially rapid-eye-movement sleep (REMS), has been considered a contributing factor to the development of PTSD symptoms through its effects on the processing of emotional memories. However, it remains unknown if sex and sex hormones play a role in the hypothesized impact of sleep on the development of PTSD. Animal models have methodological advantages over human studies in investigating this research question; however, animal models of sleep in PTSD have been tested only with males. C57BL/6 mice (7 males and 15 females) were exposed to 15 footshocks in a footshock chamber, and 5 min after the last footshock, were returned to their home cages for telemetric electroencephalographic sleep recording. Nine to thirteen days later, mice were returned to the footshock chamber for 10 min without footshocks. Fear recall rates were computed by comparing freezing behaviors in the footshock chamber immediately after the footshocks to those during fear context reexposure. Males had significantly lower recall rates compared to metestrous females (that received footshocks on metestrus). Overall, males slept more than both proestrous females (that received footshocks on proestrus) and metestrous females during the dark period. Regression analyses revealed that average REMS episode durations after footshocks were differentially associated with recall rates across groups, such that the association was positive in males, but negative in proestrous females. Results suggest that both sex and the estrous cycle modulate the associations between REMS continuity and fear memory consolidation.
journal_name
Behav Brain Resjournal_title
Behavioural brain researchauthors
Kobayashi I,Hatcher M,Wilson C,Boadi L,Poindexter M,Allard JS,Polston EKdoi
10.1016/j.bbr.2019.112156subject
Has Abstractpub_date
2020-01-27 00:00:00pages
112156eissn
0166-4328issn
1872-7549pii
S0166-4328(19)30896-4journal_volume
378pub_type
杂志文章abstract::It has recently been reported that psychotic symptoms in patients such as those with Parkinson's disease dementia (PDD) and Lewy body dementia (LBD) may worsen following treatment with memantine, a non-competitive NMDA receptor antagonist. Prepulse inhibition (PPI) of the acoustic startle response (ASR) is used as a m...
journal_title:Behavioural brain research
pub_type: 杂志文章
doi:10.1016/j.bbr.2010.11.053
更新日期:2011-03-17 00:00:00
abstract::The negative impact of chemotherapy on cognitive function in cancer patients has gained increasing attention in the last decade. Whilst the short-term acute effects on cognition are expected following chemotherapy, the persistence of such impairments in the long-term is still in question. This is despite clinical evid...
journal_title:Behavioural brain research
pub_type: 杂志文章
doi:10.1016/j.bbr.2016.07.043
更新日期:2016-12-15 00:00:00
abstract::The objective of this experiment was to examine the rewarding effect of electrical stimulation of the external lateral parabrachial nucleus (LPBe) and of the lateral hypothalamus (LH) in concurrent Conditioned Place Preference (cCPP) and Brain Self-Stimulation Rewarding tasks. As expected, LH-stimulated animals readil...
journal_title:Behavioural brain research
pub_type: 杂志文章
doi:10.1016/j.bbr.2009.07.028
更新日期:2009-12-28 00:00:00
abstract::Neonatal capsaicin administration has previously been shown to increase the threshold for withdrawal and escape response to noxious thermal, chemical and mechanical stimuli. The reason for these effects is destruction of afferent C-fibers and associated reduction in central substance P levels. In contrast, neonatal ca...
journal_title:Behavioural brain research
pub_type: 杂志文章
doi:10.1016/0166-4328(84)90150-5
更新日期:1984-08-01 00:00:00
abstract::The effect of ritanserin (5-HT2 antagonist) on scopolamine (muscarinic cholinergic antagonist)-induced amnesia in Morris water maze (MWM) was investigated. Rats were divided into eight groups and bilaterally cannulated into CA1 region of the hippocampus. One week later, they received repeatedly vehicles (saline, DMSO,...
journal_title:Behavioural brain research
pub_type: 杂志文章
doi:10.1016/j.bbr.2005.11.016
更新日期:2006-04-03 00:00:00
abstract::In order to better understand animal models of Alzheimer's disease, novel phenotyping strategies have been established for transgenic mouse models. In line with this, the current study characterised male APPxPS1 transgenic mice on mixed C57BL/6JxC3H/HeJ background for the first time for social recognition memory, sens...
journal_title:Behavioural brain research
pub_type: 杂志文章
doi:10.1016/j.bbr.2013.02.008
更新日期:2013-05-15 00:00:00
abstract::Low concentrations of ovarian hormones, among other factors, are associated with greater vulnerability to negative effects of environmental stressors and may trigger anxiety symptoms in females. The flavonoid chrysin (5,7-dihydroxyflavone) exerts anxiolytic-like effects in male and ovariectomized female rats, but it i...
journal_title:Behavioural brain research
pub_type: 杂志文章
doi:10.1016/j.bbr.2020.112952
更新日期:2021-01-15 00:00:00
abstract::Chronic cerebral hypoperfusion (CCH) may be a prodromal feature of aging-related dementias, and chronic hypertension is a major risk factor. We used a permanent, four-vessel occlusion/internal carotid artery (4-VO/ICA) model to evaluate the cognitive and neurohistological outcomes of CCH in both young and middle-aged ...
journal_title:Behavioural brain research
pub_type: 杂志文章
doi:10.1016/j.bbr.2013.05.043
更新日期:2013-09-01 00:00:00
abstract::We hypothesized that memantine, an anti-dementia drug, may be useful for the treatment of excessive daytime sleepiness. The effect of memantine on excessive sleepiness after 6 h sleep deprivation was studied in comparison with that of methylphenidate, and the involvement of the dopaminergic system in the wakefulness-p...
journal_title:Behavioural brain research
pub_type: 杂志文章
doi:10.1016/j.bbr.2009.09.025
更新日期:2010-01-20 00:00:00
abstract::Cancellation tasks are widely used for diagnosis of lateralized attentional deficits in stroke patients. A disorganized fashion of target cancellation has been hypothesized to reflect disturbed spatial exploration. In the current study we aimed to examine which lesion locations result in disorganized visual search dur...
journal_title:Behavioural brain research
pub_type: 杂志文章
doi:10.1016/j.bbr.2016.02.004
更新日期:2016-05-01 00:00:00
abstract::While the rat was performing a go/no-go alternation task with a 10-s delay period, neuronal activity was recorded from electrodes chronically implanted in the prefrontal cortex (PFC) and the dorsomedial thalamus (DMT). In both PFC and DMT, neuronal activity during the delay period prior to a 'go' response was differen...
journal_title:Behavioural brain research
pub_type: 杂志文章
doi:10.1016/0166-4328(86)90229-9
更新日期:1986-06-01 00:00:00
abstract::The Morris water maze and the object displacement task are two popular tools used to investigate spatial learning and memory. Research has focused mainly on the acquisition of spatial tasks while little attention has been given to the retention phase. We examined the effects of different training procedures on retenti...
journal_title:Behavioural brain research
pub_type: 杂志文章
doi:10.1016/s0166-4328(02)00270-x
更新日期:2003-02-17 00:00:00
abstract:BACKGROUND:The predominant view of chronic cocaine use maintains that it causes a broad range of cognitive deficits. However, concerns about the possibly deleterious impact of cocaine on cognitive functioning have yet to be thoroughly vetted. This review addresses the impact of cocaine use on such cognitive domains as ...
journal_title:Behavioural brain research
pub_type: 杂志文章,评审
doi:10.1016/j.bbr.2018.04.005
更新日期:2018-08-01 00:00:00
abstract::In a recent study with the Poffenberger paradigm, Brizzolara et al. reported longer estimates of interhemispheric transfer time (IHTT) for children aged 7 years than for adults. They interpreted this finding as evidence for incomplete functional maturity of the corpus callosum in young children. The present study was ...
journal_title:Behavioural brain research
pub_type: 杂志文章
doi:10.1016/s0166-4328(96)02261-9
更新日期:1997-07-01 00:00:00
abstract::Despite considerable evidence for potential effects of estrogen on emotional processing, several studies of postmenopausal women who began hormone therapy (HT) remote from menopause report no effects of HT on emotional measures. As early HT initiation may preserve brain mechanisms, we examined effects of HT on emotion...
journal_title:Behavioural brain research
pub_type: 杂志文章
doi:10.1016/j.bbr.2011.09.012
更新日期:2012-01-01 00:00:00
abstract::Previous study has indicated that chronic treatment with lithium protects brain against ischemic injury by reducing apoptotic death. To investigate whether lithium improves the behavioral disorder induced by transient global cerebral ischemia, we examined the effects of lithium treatment on the performance of rats in ...
journal_title:Behavioural brain research
pub_type: 杂志文章
doi:10.1016/j.bbr.2006.11.021
更新日期:2007-02-27 00:00:00
abstract::Apolipoprotein (apo) E4, one of three human apoE (h-apoE) isoforms, has been identified as a major genetic risk factor for Alzheimer's disease and for cognitive deficits associated with aging. However, the biological mechanisms involving apoE in learning and memory processes are unclear. A potential isoform-dependent ...
journal_title:Behavioural brain research
pub_type: 杂志文章
doi:10.1016/j.bbr.2008.05.008
更新日期:2008-11-21 00:00:00
abstract::The global increase in obesity rates has been tied to the rise in junk-food availability and consumption. Increasingly, children are exposed to a junk-food diet during gestation and early development. Excessive consumption of junk-food during this period may negatively impact the development of brain motivation and re...
journal_title:Behavioural brain research
pub_type: 杂志文章
doi:10.1016/j.bbr.2016.09.041
更新日期:2017-01-15 00:00:00
abstract::Three experiments compared the effects of dopamine depletion from the caudate-putamen (CAUD; dorsal striatum) or nucleus accumbens septi (NAS; ventral striatum), or a systemically administered dopamine receptor antagonist (alpha-flupenthixol) on the acquisition and performance of a conditional discrimination task invo...
journal_title:Behavioural brain research
pub_type: 杂志文章
doi:10.1016/0166-4328(90)90179-i
更新日期:1990-05-28 00:00:00
abstract::Recent rodent studies have demonstrated that parental cocaine exposure can influence offspring behavior, supporting the idea that environmental insults can impact subsequent generations. However, studies on the effects of paternal cocaine exposure are limited and multiple inconsistencies exist. In the current study, w...
journal_title:Behavioural brain research
pub_type: 杂志文章
doi:10.1016/j.bbr.2017.05.054
更新日期:2017-08-14 00:00:00
abstract::Rats were trained in a two-way active avoidance task followed immediately by a lateral hypothalamic intracranial self-stimulation (ICSS) treatment, during 5 consecutive days. The effects of the number of ICSS trains allowed (0, 500, 2500 or 4500) were studied upon acquisition and long-term retention (LTR, 10 and 30 da...
journal_title:Behavioural brain research
pub_type: 杂志文章
doi:10.1016/s0166-4328(05)80007-5
更新日期:1991-02-28 00:00:00
abstract::The endogenous opioid system is involved in ethanol reinforcement. Ethanol-induced changes in opioidergic transmission have been extensively studied in adult organisms. However, the impact of ethanol exposure at low or moderate doses during early ontogeny has been barely explored. We investigated the effect of prenata...
journal_title:Behavioural brain research
pub_type: 杂志文章
doi:10.1016/j.bbr.2014.08.022
更新日期:2014-11-01 00:00:00
abstract::The radial arm maze (RAM) is a common behavioral test to assess spatial working and reference memory in mice. However, conventional RAM experiments require a substantial degree of manual handling and animals are usually subjected to prolonged periods of food or water deprivation to achieve sufficient learning motivati...
journal_title:Behavioural brain research
pub_type: 杂志文章
doi:10.1016/j.bbr.2019.112352
更新日期:2020-03-02 00:00:00
abstract::Although human spatial cognition is at the focus of intense research efforts, experimental evidence on how search strategies differ among age and gender groups remains elusive. To address this problem, we investigated the interaction between age, sex, and strategy usage within a novel virtual water maze-like procedure...
journal_title:Behavioural brain research
pub_type: 杂志文章
doi:10.1016/j.bbr.2009.11.022
更新日期:2010-03-17 00:00:00
abstract::In humans, the Simon effect refers to the fact that choice reaction time (RT) is shorter when the stimulus corresponds spatially to the response than when it does not, albeit the location of the stimulus is irrelevant to the task. This effect has motivated innumerable empirical and theoretical studies and is considere...
journal_title:Behavioural brain research
pub_type: 杂志文章
doi:10.1016/j.bbr.2007.01.012
更新日期:2007-04-16 00:00:00
abstract::Autism is characterized by deficits in social interaction and social recognition. Although animal models of autism have demonstrated that model animals engage less in social interaction or attend less to conspecifics than control animals, no animal model has yet replicated the deficit in recognition of complex social ...
journal_title:Behavioural brain research
pub_type: 杂志文章
doi:10.1016/j.bbr.2015.06.006
更新日期:2015-10-01 00:00:00
abstract::Sensory-motor development begins early during embryogenesis and is influenced by sensory experience. Little is known about the prenatal factors that influence the development of motor coordination. Here we investigated whether and to what extent prenatal light experience can influence the development of motor coordina...
journal_title:Behavioural brain research
pub_type: 杂志文章
doi:10.1016/j.bbr.2017.03.039
更新日期:2017-06-01 00:00:00
abstract::A primary aim in the neuroscientific study of depression is to identify the brain areas involved in the pathogenesis of symptoms. In this review, we describe evidence from studies employing various experimental approaches in humans (functional imaging, lesion method, and brain stimulation) that converge to implicate t...
journal_title:Behavioural brain research
pub_type: 杂志文章,评审
doi:10.1016/j.bbr.2009.03.004
更新日期:2009-08-12 00:00:00
abstract::Herein, we investigated the effect Salvia sahendica (S. sahenica) extract, an endemic plant of Iran on the improvement of learning and memory deficits in amyloid beta-(Aβ) injected rats. In order to test this hypothesis, we pretreated rats with S. sahendica 1 week prior to Aβ injection, then performed Morris water maz...
journal_title:Behavioural brain research
pub_type: 杂志文章
doi:10.1016/j.bbr.2012.11.026
更新日期:2013-03-15 00:00:00
abstract::The phenomenon of dissociated memory retrieval is observed when some influences (for example, pharmacological) on the brain result in specific changes of long-term memory. The purpose of present paper is to reveal possibilities of the phenomenon for study of long-term memory retrieval. Pharmacologically-induced dissoc...
journal_title:Behavioural brain research
pub_type: 杂志文章
doi:10.1016/s0166-4328(99)00090-x
更新日期:1999-12-01 00:00:00