Abstract：
:Research into object recognition memory has been galvanised by the introduction of spontaneous preference tests for rodents. The standard task, however, contains a number of inherent shortcomings that reduce its power. Particular issues include the problem that individual trials are time consuming, so limiting the total number of trials in any condition. In addition, the spontaneous nature of the behaviour and the variability between test objects add unwanted noise. To combat these issues, the 'bow-tie maze' was introduced. Although still based on the spontaneous preference of novel over familiar stimuli, the ability to give multiple trials within a session without handling the rodents, as well as using the same objects as both novel and familiar samples on different trials, overcomes key limitations in the standard task. Giving multiple trials within a single session also creates new opportunities for functional imaging of object recognition memory. A series of studies are described that examine the expression of the immediate-early gene, c-fos. Object recognition memory is associated with increases in perirhinal cortex and area Te2 c-fos activity. When rats explore novel objects the pathway from the perirhinal cortex to lateral entorhinal cortex, and then to the dentate gyrus and CA3, is engaged. In contrast, when familiar objects are explored the pathway from the perirhinal cortex to lateral entorhinal cortex, and then to CA1, takes precedence. The switch to the perforant pathway (novel stimuli) from the temporoammonic pathway (familiar stimuli) may assist the enhanced associative learning promoted by novel stimuli.
journal_name
Behav Brain Resjournal_title
Behavioural brain researchauthors
Kinnavane L,Albasser MM,Aggleton JPdoi
10.1016/j.bbr.2014.07.049subject
Has Abstractpub_date
2015-05-15 00:00:00pages
67-78eissn
0166-4328issn
1872-7549pii
S0166-4328(14)00498-7journal_volume
285pub_type
杂志文章,评审abstract：:Rats with aspiration or excitotoxic (NMDA) lesions of the parahippocampal region were trained on a series of behavioral tasks which consisted of: (1) a test of spatial memory (discrete trial rewarded alternation), (2) a black-white discrimination, and (3) a test of non-spatial memory commonly used in primate models of...
journal_title：Behavioural brain research
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abstract：:Effects of aspiration lesions of the cerebral cortex on the behavioral effects of intraventricular substantia nigra grafts were investigated. Apomorphine-induced rotational behavior consequent to unilateral lesions of the substantia nigra was used as a behavioral measure. Substantia nigra grafts reduced rotational beh...
journal_title：Behavioural brain research
pub_type： 杂志文章
doi：10.1016/s0166-4328(89)80060-9
更新日期：1989-04-01 00:00:00
abstract：:Measurement of cardiac and respiratory activity during mental simulation of locomotion at increasing speed revealed a covariation of heart rate and pulmonary ventilation with the degree of imagined effort. The degree of vegetative activation of a subject mentally running at 12 km/h was comparable to that of a subject ...
journal_title：Behavioural brain research
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journal_title：Behavioural brain research
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abstract：:A primary aim in the neuroscientific study of depression is to identify the brain areas involved in the pathogenesis of symptoms. In this review, we describe evidence from studies employing various experimental approaches in humans (functional imaging, lesion method, and brain stimulation) that converge to implicate t...
journal_title：Behavioural brain research
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journal_title：Behavioural brain research
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journal_title：Behavioural brain research
pub_type： 杂志文章,评审
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更新日期：2019-09-02 00:00:00
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journal_title：Behavioural brain research
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journal_title：Behavioural brain research
pub_type： 杂志文章
doi：10.1016/0166-4328(90)90118-x
更新日期：1990-06-18 00:00:00
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journal_title：Behavioural brain research
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doi：10.1016/s0166-4328(89)80102-0
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journal_title：Behavioural brain research
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journal_title：Behavioural brain research
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doi：10.1016/j.bbr.2012.10.004
更新日期：2013-02-01 00:00:00
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journal_title：Behavioural brain research
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doi：10.1016/j.bbr.2012.05.004
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journal_title：Behavioural brain research
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更新日期：1994-08-31 00:00:00
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journal_title：Behavioural brain research
pub_type： 杂志文章
doi：10.1016/0166-4328(94)90054-x
更新日期：1994-07-29 00:00:00
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journal_title：Behavioural brain research
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journal_title：Behavioural brain research
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journal_title：Behavioural brain research
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journal_title：Behavioural brain research
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journal_title：Behavioural brain research
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doi：10.1016/j.bbr.2006.02.004
更新日期：2006-05-15 00:00:00
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journal_title：Behavioural brain research
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doi：10.1016/j.bbr.2013.11.040
更新日期：2014-03-01 00:00:00
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journal_title：Behavioural brain research
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doi：10.1016/0166-4328(85)90060-9
更新日期：1985-04-01 00:00:00
abstract：:Psychostimulant substances have been found to either increase or inhibit impulsive choice (preference to choose small immediate reward over large delayed reward) in laboratory animals. Although central dopamine transmission has been demonstrated to be involved in impulsivity and drug addiction, little is known regardi...
journal_title：Behavioural brain research
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更新日期：2015-01-01 00:00:00
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journal_title：Behavioural brain research
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abstract：:Human voluntary isometric maximum muscle strength during simultaneous bilateral versus separate unilateral elbow extension and flexion was measured. The following results were obtained. (1) Strength was reduced under the condition of simultaneous bilateral exertion of contralateral corresponding muscles as compared to...
journal_title：Behavioural brain research
pub_type： 杂志文章
doi：10.1016/0166-4328(83)90190-0
更新日期：1983-02-01 00:00:00
abstract：:Many insects are known to exhibit clear circadian rest-activity rhythms. Attention has focussed more on active behaviors such as locomotion than on rest. I investigated the consequences of disturbances of the rest period on activity states of the cockroach Leucophea maderae. The 24-h rest-activity rhythm of individual...
journal_title：Behavioural brain research
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doi：10.1016/0166-4328(83)90180-8
更新日期：1983-06-01 00:00:00
