Persistent neurochemical and behavioral abnormalities in adulthood despite early iron supplementation for perinatal iron deficiency anemia in rats.


BACKGROUND:Iron deficiency anemia (IDA) has been associated with altered cognitive, motor, and social-emotional outcomes in human infants. We recently reported that rats with chronic perinatal IDA, had altered regional brain iron, monoamines, and sensorimotor skill emergence during early development. OBJECTIVE:To examine the long-term consequences of chronic perinatal IDA on behavior, brain iron and monoamine systems after dietary iron treatment in rats. METHODS:Sixty dams were randomly assigned to iron-sufficient (CN) or low-iron (EID) diets during gestation and lactation. Thereafter, all offspring were fed the iron-sufficient diet, assessed for hematology and behavior after weaning and into adulthood and for brain measures as adults (regional brain iron, monoamines, dopamine and serotonin transporters, and dopamine receptor). Behavioral assessments included sensorimotor function, general activity, response to novelty, spatial alternation, and spatial water maze performance. RESULTS:Hematology and growth were similar for EID and CN rats by postnatal day 35. In adulthood, EID thalamic iron content was lower. Monoamines, dopamine transporter, and dopamine receptor concentrations did not differ from CN. EID serotonin transporter concentration was reduced in striatum and related regions. EID rats had persisting sensorimotor deficits (delayed vibrissae-evoked forelimb placing, longer sticker removal time, and more imperfect grooming chains), were more hesitant in novel settings, and had poorer spatial water maze performance than CN. General activity and spatial alternation were similar for EID and CN. CONCLUSION:Rats that had chronic perinatal IDA showed behavioral impairments that suggest persistent striatal dopamine and hippocampal dysfunction despite normalization of hematology, growth and most brain measures.


Behav Brain Res


Felt BT,Beard JL,Schallert T,Shao J,Aldridge JW,Connor JR,Georgieff MK,Lozoff B




Has Abstract


2006-08-10 00:00:00














  • Cannabinoids negatively modulate striatal glutamate and dopamine release and behavioural output of acute D-amphetamine.

    abstract::The cannabinoid system plays a regulatory role in neurotransmission and is involved in the central actions of psychostimulants. This complex interaction between the cannabinoid system and psychostimulants represents a potential pharmacological target for psychosis and addiction. However, most studies have focused on c...

    journal_title:Behavioural brain research

    pub_type: 杂志文章


    authors: Polissidis A,Chouliara O,Galanopoulos A,Naxakis G,Papahatjis D,Papadopoulou-Daifoti Z,Antoniou K

    更新日期:2014-08-15 00:00:00

  • Locomotion analysis of Sprague-Dawley rats before and after injecting 6-OHDA.

    abstract::The hypothesis that changes in measured ground reaction forces and time parameters during locomotion can noninvasively detect Parkinsonism in unilateral 6-OH dopamine (6-OHDA) lesioned rats is tested. It was found that changes of seven locomotion parameters can be used to construct a logistic regression model with a d...

    journal_title:Behavioural brain research

    pub_type: 杂志文章


    authors: Tang W,McDowell K,Limsam M,Neerchal NK,Yarowsky P,Tasch U

    更新日期:2010-06-26 00:00:00

  • Motion sensitive cells in the macaque superior temporal polysensory area: response discrimination between self-generated and externally generated pattern motion.

    abstract::It was previously shown [17] that visual movement sensitive neurons lacking selectivity in the anterior parts of the dorsal superior temporal sulcus (STP) of monkeys exhibited selective responses to externally moved objects and failed to respond to the sight of the animal's own limb movements. This paper describes a s...

    journal_title:Behavioural brain research

    pub_type: 杂志文章


    authors: Hietanen JK,Perrett DI

    更新日期:1996-04-01 00:00:00

  • Involvement of the brain serotonergic system in the locomotor stimulant effects of chlorpheniramine in Wistar rats: implication of postsynaptic 5-HT1A receptors.

    abstract::Antihistamines, such as chlorpheniramine (CPA), are lipophilic agents which readily cross the blood-brain barrier, producing sedation in 10-25% of users. However, with excessive doses instead of sedation a stimulating action has been reported. The aim of the present study was to investigate the influence of CPA on the...

    journal_title:Behavioural brain research

    pub_type: 杂志文章


    authors: Karamanakos PN,Pappas P,Marselos M

    更新日期:2004-01-05 00:00:00

  • Morphine self-administration into the lateral septum depends on dopaminergic mechanisms: Evidence from pharmacology and Fos neuroimaging.

    abstract::Mice self-administer morphine into the lateral septum (LS), but the neuronal connections underlying this behaviour remain unknown. The present study tested whether the acquisition of intra-LS morphine self-administration depends on dopaminergic mechanisms. Mice were allowed to self-inject morphine (5 or 20ng/50nl) or ...

    journal_title:Behavioural brain research

    pub_type: 杂志文章


    authors: Le Merrer J,Gavello-Baudy S,Galey D,Cazala P

    更新日期:2007-06-18 00:00:00

  • The cognitive and histopathological effects of chronic 4-vessel occlusion in rats depend on the set of vessels occluded and the age of the animals.

    abstract::Continuing previous efforts to develop the 4-vessel occlusion (4-VO) model of chronic cerebral hypoperfusion (CCH), here we evaluated whether permanent, stepwise 4-VO causes both learning deficits, hippocampal neurodegeneration and retinal lesion in young, middle-aged or aged rats. Chronic 4-VO was induced by ligation...

    journal_title:Behavioural brain research

    pub_type: 杂志文章


    authors: Barros CA,Ekuni R,Moro MA,Pereira FM,Dos Santos Pereira MA,Milani H

    更新日期:2009-02-11 00:00:00

  • Effects of internal and external factors on the budgeting between defensive and non-defensive responses in Aplysia.

    abstract::Following exposure to aversive stimuli, organisms budget their behaviors by augmenting defensive responses and reducing/suppressing non-defensive behaviors. This budgeting process must be flexible to accommodate modifications in the animal's internal and/or external state that require the normal balance between defens...

    journal_title:Behavioural brain research

    pub_type: 杂志文章


    authors: Leod KAM,Seas A,Wainwright ML,Mozzachiodi R

    更新日期:2018-09-03 00:00:00

  • Links between breeding readiness, opioid immunolabeling, and the affective state induced by hearing male courtship song in female European starlings (Sturnus vulgaris).

    abstract::Male courtship vocalizations represent a potent signal designed to attract females; however, not all females find male signals equally attractive. We explored the possibility that the affective state induced by hearing courtship vocalizations depends on the motivational state of a receiver. We used a conditioned place...

    journal_title:Behavioural brain research

    pub_type: 杂志文章


    authors: Riters LV,Ellis JM,Angyal CS,Borkowski VJ,Cordes MA,Stevenson SA

    更新日期:2013-06-15 00:00:00

  • Defeat-induced activation of the ventral medial prefrontal cortex is necessary for resistance to conditioned defeat.

    abstract::The ventral medial prefrontal cortex (vmPFC) controls vulnerability to the negative effects of chronic or uncontrollable stress. Dominance status alters responses to social defeat in the conditioned defeat model, which is a model characterized by loss of territorial aggression and increased submissive and defensive be...

    journal_title:Behavioural brain research

    pub_type: 杂志文章


    authors: Morrison KE,Bader LR,McLaughlin CN,Cooper MA

    更新日期:2013-04-15 00:00:00

  • Basolateral amygdala lesions attenuate safe taste memory-related c-fos expression in the rat perirhinal cortex.

    abstract::Previous results indicated that damage and pharmacological inactivation of the basolateral amygdala (BLA) interfere with the attenuation of taste neophobia. A similar disruption of safe taste memories formation induced by the inhibition of protein synthesis in the perirhinal cortex (PRh) has been reported. Thus, we ha...

    journal_title:Behavioural brain research

    pub_type: 杂志文章


    authors: Gómez-Chacón B,Gámiz F,Gallo M

    更新日期:2012-05-01 00:00:00

  • DSP-4, a noradrenergic neurotoxin, produces sex-specific effects on pairing and courtship behavior in zebra finches.

    abstract::Norepinephrine (NE) is involved in a variety of behaviors across vertebrate species. In songbirds, NE is involved in singing and auditory perception, fundamental components of pair formation. Mechanisms of pairing remain poorly understood in avian species. NE is likely involved given its role in vocal communication an...

    journal_title:Behavioural brain research

    pub_type: 杂志文章


    authors: Vahaba DM,Lacey WH,Tomaszycki ML

    更新日期:2013-09-01 00:00:00

  • Behavioral response to novelty correlates with dopamine receptor availability in striatum of Göttingen minipigs.

    abstract::Behavioral response to novelty in rats has been linked both to dopamine transmission in the ventral striatum, and to propensity to self-administer psychostimulant drugs. In order to probe the relationship between behavioral response to novelty and dopamine systems we have developed a behavioral model for correlation w...

    journal_title:Behavioural brain research

    pub_type: 杂志文章


    authors: Lind NM,Gjedde A,Moustgaard A,Olsen AK,Jensen SB,Jakobsen S,Arnfred SM,Hansen AK,Hemmingsen RP,Cumming P

    更新日期:2005-11-07 00:00:00

  • Investigation into the effects of the novel antipsychotic ziprasidone on weight gain and reproductive function in female rats.

    abstract::Weight gain and sexual dysfunction are serious side effects of certain antipsychotic drugs. Ziprasidone, a novel antipsychotic with a unique receptor binding profile, is reported to have a low propensity for such side effects. Previous results from this laboratory have demonstrated substantial weight gain following su...

    journal_title:Behavioural brain research

    pub_type: 杂志文章


    authors: Fell MJ,Gibson R,McDermott E,Sisodia G,Marshall KM,Neill JC

    更新日期:2005-05-28 00:00:00

  • Exposure to different wavelengths of light and the development of structural and functional asymmetries in the chicken.

    abstract::The thalamofugal visual projections of the chick are known to develop in response to stimulation by light prior to hatching, and asymmetry in the number of projections develops as a consequence of the embryo being oriented in the egg so that it occuludes its left eye. The right eye only is stimulated by light and this...

    journal_title:Behavioural brain research

    pub_type: 杂志文章


    authors: Rogers LJ,Krebs GA

    更新日期:1996-10-01 00:00:00

  • Effects of D-cycloserine on the behavior and ERK activity in the amygdala: role of individual anxiety levels.

    abstract::Low dose of D-cycloserine (DCS), a partial agonist of glycine binding site on N-methyl-D-aspartate (NMDA) receptors, can facilitate extracellular signal-regulated kinase1/2 (ERK1/2) activity in the amygdala and modulate emotional behavior. However, the relationship between ERK1/2 activation, individual anxiety levels,...

    journal_title:Behavioural brain research

    pub_type: 杂志文章


    authors: Wu SL,Hsu LS,Tu WT,Wang WF,Huang YT,Pawlak CR,Ho YJ

    更新日期:2008-03-05 00:00:00

  • One-trial object recognition in rats and mice: methodological and theoretical issues.

    abstract::The one-trial object recognition task involves memory of a familiar object in parallel with the detection and encoding of a novel object. It provides the basis for the study of a wide range of cognitive and neuropsychological functions and processes in rats and mice. However, unlike in humans, primate and pigeon studi...

    journal_title:Behavioural brain research

    pub_type: 杂志文章,评审


    authors: Ennaceur A

    更新日期:2010-12-31 00:00:00

  • Lateral neglect in a head movement task: more impairment with unilateral than bilateral lesions of the superior colliculus in the rat.

    abstract::Unilateral lesions of the superior colliculus produce contralateral neglect. This study determined if bilateral lesions would impair head orientation in a way expected from the summation of two contralateral neglects. Rats were trained to make various head movements to get water at a 3 x 3 array of holes, each with a ...

    journal_title:Behavioural brain research

    pub_type: 杂志文章


    authors: Sinnamon HM,Garcia EJ

    更新日期:1988-02-01 00:00:00

  • Exercise effects on motor and affective behavior and catecholamine neurochemistry in the MPTP-lesioned mouse.

    abstract::This study used 1-methyl-4-phenyl-1,2,3,6,-tetrahydropyridine (MPTP) in mice to determine if exercise improves behavior and dopamine (DA) and serotonin (5HT) content. Male C57BL/6 mice received MPTP (4 x 20mg/kg) or saline. They remained sedentary or exercised by treadmill or voluntary running wheel for 6 weeks (n=8/g...

    journal_title:Behavioural brain research

    pub_type: 杂志文章


    authors: Gorton LM,Vuckovic MG,Vertelkina N,Petzinger GM,Jakowec MW,Wood RI

    更新日期:2010-12-01 00:00:00

  • Inferior olivary inactivation abolishes conditioned eyeblinks: extinction or cerebellar malfunction?

    abstract::The inferior olive (IO) is a required component of neural circuits controlling the classical conditioning of eyeblink responses. Previous reports indicated that lesioning or inactivating the IO abolishes conditioned eyeblinks (CRs), but there was disagreement regarding the timing of the CR performance deficit. As a re...

    journal_title:Behavioural brain research

    pub_type: 杂志文章


    authors: Zbarska S,Holland EA,Bloedel JR,Bracha V

    更新日期:2007-03-12 00:00:00

  • Anxiolytic and anxiogenic effects of kindling--role of baseline anxiety and anatomical location of the kindling electrode in response to kindling of the right and left basolateral amygdala.

    abstract::Effects of kindling of right and left basolateral amygdala (BLA) on plus maze anxiety was studied. Using a validated retest paradigm, it was possible to retest rats in the plus maze without increasing anxiety on retest. This permitted determining prekindling baseline levels of plus maze anxiety. Right BLA kindling of ...

    journal_title:Behavioural brain research

    pub_type: 杂志文章


    authors: Adamec R,Shallow T,Burton P

    更新日期:2005-04-15 00:00:00

  • Genetic predisposition to obesity affects behavioural traits including food reward and anxiety-like behaviour in rats.

    abstract::Here we sought to define behavioural traits linked to anxiety, reward, and exploration in different strains of rats commonly used in obesity research. We hypothesized that genetic variance may contribute not only to their metabolic phenotype (that is well documented) but also to the expression of these behavioural tra...

    journal_title:Behavioural brain research

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    authors: Vogel H,Kraemer M,Rabasa C,Askevik K,Adan RAH,Dickson SL

    更新日期:2017-06-15 00:00:00

  • Light experience and the development of behavioural lateralisation in chicks. II. Choice of familiar versus unfamiliar model social partner.

    abstract::In late-stage embryos of domestic fowl, exposure of the right eye to light entering through the shell induces asymmetry of the thalamofugal visual pathway, together with differences in performance according to whether the right or left eye (RE, LE) is in use (Behav. Brain Res. 38 (1990) 211). Nevertheless, at least so...

    journal_title:Behavioural brain research

    pub_type: 杂志文章


    authors: Andrew RJ,Johnston AN,Robins A,Rogers LJ

    更新日期:2004-11-05 00:00:00

  • Locomotor sites mapped with low current stimulation in intact and kainic acid damaged hypothalamus of anesthetized rats.

    abstract::To determine whether local neurons mediated the locomotor effects of electrical stimulation of the lateral hypothalamus, kainic acid injections (0.5-1.25 micrograms), intended to destroy neural somata as opposed to fibers of passage, were made unilaterally in the tuberal-posterior hypothalamus of 22 rats. The area of ...

    journal_title:Behavioural brain research

    pub_type: 杂志文章


    authors: Sinnamon HM,Marciello M,Goerner DW

    更新日期:1991-12-13 00:00:00

  • Memory dissociation: the approach to the study of retrieval processes.

    abstract::The phenomenon of dissociated memory retrieval is observed when some influences (for example, pharmacological) on the brain result in specific changes of long-term memory. The purpose of present paper is to reveal possibilities of the phenomenon for study of long-term memory retrieval. Pharmacologically-induced dissoc...

    journal_title:Behavioural brain research

    pub_type: 杂志文章


    authors: Arkhipov VI

    更新日期:1999-12-01 00:00:00

  • How does the corpus callosum mediate interhemispheric transfer? A review.

    abstract::The corpus callosum is the largest white matter structure in the human brain, connecting cortical regions of both hemispheres. Complete and partial callosotomies or callosal lesion studies have granted more insight into the function of the corpus callosum, namely the facilitation of communication between the cerebral ...

    journal_title:Behavioural brain research

    pub_type: 杂志文章,评审


    authors: van der Knaap LJ,van der Ham IJ

    更新日期:2011-09-30 00:00:00

  • Early enriched environment induces an increased conversion of proBDNF to BDNF in the adult rat's hippocampus.

    abstract::An enriched environment has been shown to influence brain plasticity and function by involving the action of brain-derived neurotrophic factor (BDNF). BDNF, which is synthesized as a precursor molecule (proBDNF) that undergoes proteolytic cleavage, plays an important role in synaptic plasticity and contributes to seve...

    journal_title:Behavioural brain research

    pub_type: 杂志文章


    authors: Cao W,Duan J,Wang X,Zhong X,Hu Z,Huang F,Wang H,Zhang J,Li F,Zhang J,Luo X,Li CQ

    更新日期:2014-05-15 00:00:00

  • Chemotherapy drug thioTEPA exacerbates stress-induced anhedonia and corticosteroid responses but not impairment of hippocampal cell proliferation in adult mice.

    abstract::Cancer patients often suffer long-lasting affective and cognitive impairments as a result of chemotherapy treatment. Previous work in our lab has shown deficits in learning and memory and hippocampal cell proliferation in mice lasting up to 20 weeks following acute administration of thioTEPA. In this study, the effect...

    journal_title:Behavioural brain research

    pub_type: 杂志文章


    authors: Wilson CL,Weber ET

    更新日期:2013-01-01 00:00:00

  • Functional brain asymmetry in adult novelty response: on fluidity of neonatal novelty exposure effects.

    abstract::Novelty and surprises differentially modify the left and right sides of the brain. Here we show that repeated brief exposures to the novelty of a non-home environment during infancy and early adulthood lead to long-lasting changes in adulthood in the global bi-lateralization organization of the brain as indexed by a t...

    journal_title:Behavioural brain research

    pub_type: 杂志文章


    authors: Tang AC,Reeb-Sutherland B,Yang Z

    更新日期:2011-08-01 00:00:00

  • Increase of spike-LFP coordination in rat prefrontal cortex during working memory.

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    journal_title:Behavioural brain research

    pub_type: 杂志文章


    authors: Li S,Ouyang M,Liu T,Bai W,Yi H,Tian X

    更新日期:2014-03-15 00:00:00

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    abstract::The present report provides evidence that repeated immobilization stress (RIS) induced a noradrenergic-dependent depressive-like behaviour and an augmented behavioural response to desipramine (DMI), a noradrenaline reuptake inhibitor (NRI), in the forced swimming test (FST). The present results show that RIS decreased...

    journal_title:Behavioural brain research

    pub_type: 杂志文章


    authors: Hadweh N,Santibañez M,González MP,Forray MI

    更新日期:2010-12-25 00:00:00