Abstract：
:Alcohol dependence and alcohol abuse represent major unmet medical needs. The zebrafish is considered to be a promising vertebrate species with which the effects of alcohol on brain function and behavior and the mechanisms underlying these effects may be studied. Alcohol is known to induce alterations in motor function as well as fear and anxiety. Here we utilize a recently developed fear paradigm in which we employ an animated (moving) image of a bird silhouette. We measure the effect of acute alcohol administration (dose range employed: 0.00-0.75 vol/vol percentage, bath exposure for 60 min) on the behavioral responses of zebrafish. We test these responses during a pre-stimulus, stimulus and post-stimulus period of the task using both a video-tracking and an observation based quantification method. The fear inducing stimulus was found to decrease the distance of the zebrafish from the bottom of the tank, to increase number of erratic movements, and to increase the number of jumps in alcohol exposed fish (versus control fish). Alcohol attenuated these fear responses in a dose dependent manner. In addition, alcohol decreased general activity at the highest dose, an effect that was independent of the presentation of the stimulus. We discuss the similarities and differences between observation and video-tracking based results and conclude that fear paradigms will be useful in revealing alcohol induced functional changes in the brain of zebrafish.
journal_name
Behav Brain Resjournal_title
Behavioural brain researchauthors
Luca RM,Gerlai Rdoi
10.1016/j.bbr.2012.01.021subject
Has Abstractpub_date
2012-04-01 00:00:00pages
194-201issue
1eissn
0166-4328issn
1872-7549pii
S0166-4328(12)00040-Xjournal_volume
229pub_type
杂志文章abstract：:In order to find out whether the inferior colliculus, in addition to its auditory decoding function, also has an auditory gating function in the sense that it treats self-produced sounds differently from external ones, we have explored the inferior colliculus and bordering tegmentum for neurones reacting differently t...
journal_title：Behavioural brain research
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journal_title：Behavioural brain research
pub_type： 杂志文章
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更新日期：1999-09-01 00:00:00
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journal_title：Behavioural brain research
pub_type： 杂志文章
doi：10.1016/j.bbr.2017.08.036
更新日期：2018-01-15 00:00:00
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journal_title：Behavioural brain research
pub_type： 杂志文章
doi：10.1016/j.bbr.2004.11.027
更新日期：2005-04-30 00:00:00
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journal_title：Behavioural brain research
pub_type： 杂志文章
doi：10.1016/j.bbr.2010.03.044
更新日期：2010-08-25 00:00:00
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journal_title：Behavioural brain research
pub_type： 杂志文章
doi：10.1016/j.bbr.2016.07.031
更新日期：2016-10-15 00:00:00
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journal_title：Behavioural brain research
pub_type： 杂志文章
doi：10.1016/j.bbr.2006.02.029
更新日期：2006-06-30 00:00:00
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journal_title：Behavioural brain research
pub_type： 杂志文章
doi：10.1016/j.bbr.2016.05.036
更新日期：2016-09-15 00:00:00
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journal_title：Behavioural brain research
pub_type： 杂志文章
doi：10.1016/j.bbr.2009.12.005
更新日期：2010-04-02 00:00:00
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更新日期：2018-07-16 00:00:00
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pub_type： 杂志文章
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更新日期：2011-01-20 00:00:00
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pub_type： 杂志文章
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journal_title：Behavioural brain research
pub_type： 杂志文章,评审
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更新日期：2020-12-24 00:00:00
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pub_type： 杂志文章
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更新日期：2019-01-01 00:00:00
