Abstract：
:Increased perseveration is associated with aging and leads to an impaired ability to cope with problems. Aging is also associated with progressing dysfunction of the cholinergic system which is involved in the regulation of various cognitive processes. Therefore, we tested an effect of an anticholinergic drug on the level of perseveration in mice subjected to the detour test. The subjects tested on this task are expected to disengage from visually guided behavior and to move around a transparent barrier instead of traveling to the target directly along the line of sight. The failure to inhibit prepotent motivational drive leads to perseveration during the task. Our experiment showed that scopolamine increased perseveration in mice and this finding points to the involvement of muscarinic receptors in the control of perseveration. This study also shows that a mouse detour task is a suitable model for detecting the effect of anticholinergic drugs on perseveration in contrast to the previously applied tests.
journal_name
Behav Brain Resjournal_title
Behavioural brain researchauthors
Juszczak GR,Stryjek Rdoi
10.1016/j.bbr.2018.07.028subject
Has Abstractpub_date
2019-01-01 00:00:00pages
71-77eissn
0166-4328issn
1872-7549pii
S0166-4328(18)30320-6journal_volume
356pub_type
杂志文章abstract：:The electrical and chemical stimulation of the dorsal periaqueductal grey matter (dPAG) elicits panic-like explosive escape behaviour. Although neurons of the ventromedial hypothalamus (VMH) seem to organise oriented escape behaviour, when stimulated with excitatory amino acids at higher doses, non-oriented/explosive ...
journal_title：Behavioural brain research
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journal_title：Behavioural brain research
pub_type： 杂志文章
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journal_title：Behavioural brain research
pub_type： 杂志文章
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journal_title：Behavioural brain research
pub_type： 杂志文章
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journal_title：Behavioural brain research
pub_type： 杂志文章
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更新日期：2015-10-15 00:00:00
abstract：:Zinc is an important element in all cells of the body, having structural, enzymatic, and regulatory functions. In some neurons, zinc is loaded into synaptic vesicles by zinc transporter 3 (ZnT3) and released into the synaptic cleft, where it can modulate neuronal function. ZnT3 knockout (KO) mice lack ZnT3 and thus la...
journal_title：Behavioural brain research
pub_type： 杂志文章
doi：10.1016/j.bbr.2016.12.028
更新日期：2017-03-15 00:00:00
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更新日期：2010-12-06 00:00:00
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journal_title：Behavioural brain research
pub_type： 杂志文章
doi：10.1016/j.bbr.2013.03.018
更新日期：2013-06-15 00:00:00
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pub_type： 杂志文章
doi：10.1016/0166-4328(93)90045-r
更新日期：1993-03-31 00:00:00
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journal_title：Behavioural brain research
pub_type： 杂志文章
doi：10.1016/j.bbr.2004.02.001
更新日期：2004-09-23 00:00:00
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journal_title：Behavioural brain research
pub_type： 杂志文章
doi：10.1016/0166-4328(83)90041-4
更新日期：1983-12-01 00:00:00
abstract：:In this review I focus on how three methodological principles advocated by Philip Teitelbaum influenced my work to this day: that similar principles of organization should be looked for in ontogeny and recovery of function; that the order of emergence of behavioral components provides a view on the organization of tha...
journal_title：Behavioural brain research
pub_type： 杂志文章,评审
doi：10.1016/j.bbr.2012.01.039
更新日期：2012-06-01 00:00:00
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journal_title：Behavioural brain research
pub_type： 杂志文章
doi：10.1016/j.bbr.2016.12.006
更新日期：2017-03-01 00:00:00
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journal_title：Behavioural brain research
pub_type： 杂志文章,评审
doi：10.1016/j.bbr.2009.12.036
更新日期：2010-12-31 00:00:00
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journal_title：Behavioural brain research
pub_type： 杂志文章
doi：10.1016/j.bbr.2010.04.005
更新日期：2010-10-15 00:00:00
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journal_title：Behavioural brain research
pub_type： 杂志文章,随机对照试验
doi：10.1016/j.bbr.2012.11.015
更新日期：2013-03-01 00:00:00
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journal_title：Behavioural brain research
pub_type： 杂志文章
doi：10.1016/j.bbr.2007.07.030
更新日期：2008-01-10 00:00:00
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journal_title：Behavioural brain research
pub_type： 杂志文章
doi：10.1016/j.bbr.2017.05.027
更新日期：2017-07-28 00:00:00
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journal_title：Behavioural brain research
pub_type： 临床试验,杂志文章,随机对照试验
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更新日期：2000-03-01 00:00:00
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journal_title：Behavioural brain research
pub_type： 杂志文章
doi：10.1016/j.bbr.2014.03.029
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journal_title：Behavioural brain research
pub_type： 杂志文章
doi：10.1016/j.bbr.2015.01.025
更新日期：2015-04-15 00:00:00
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journal_title：Behavioural brain research
pub_type： 杂志文章
doi：10.1016/j.bbr.2007.02.030
更新日期：2007-05-16 00:00:00
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journal_title：Behavioural brain research
pub_type： 杂志文章,评审
doi：10.1016/j.bbr.2009.12.024
更新日期：2010-05-01 00:00:00
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journal_title：Behavioural brain research
pub_type： 杂志文章
doi：10.1016/j.bbr.2012.10.053
更新日期：2013-03-01 00:00:00
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journal_title：Behavioural brain research
pub_type： 杂志文章
doi：10.1016/0166-4328(88)90094-0
更新日期：1988-04-01 00:00:00
abstract：:Humans can perform, perceive, and imagine voluntary movement. Numerous investigations of these abilities have employed variants of goal-directed aiming tasks because the Fitts's law equation reliably captures the mathematical relationship between movement time (MT) and accuracy requirements. The emergence of Fitts's s...
journal_title：Behavioural brain research
pub_type： 杂志文章
doi：10.1016/j.bbr.2013.09.045
更新日期：2013-11-15 00:00:00
abstract：:Gangliosides are compounds that are abundant throughout the CNS, participating actively in neuroplasticity. We previously described that exogenous GM1 ganglioside pretreatment enhances the rewarding properties of cocaine, evidenced by a lower number of sessions and/or dosage necessary to induce conditioned place prefe...
journal_title：Behavioural brain research
pub_type： 杂志文章
doi：10.1016/j.bbr.2014.10.013
更新日期：2015-02-01 00:00:00
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journal_title：Behavioural brain research
pub_type： 杂志文章
doi：10.1016/j.bbr.2008.01.002
更新日期：2008-06-03 00:00:00
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journal_title：Behavioural brain research
pub_type： 杂志文章
doi：10.1016/j.bbr.2003.11.005
更新日期：2004-08-12 00:00:00
abstract：:Many patients who have received chemotherapy to treat cancer experience depressive- and anxiety-like symptoms or cognitive impairment. However, despite the evidence for this, the underlying mechanisms are still not understood. This study investigated behavioral and biochemical changes upon treatment with doxorubicin a...
journal_title：Behavioural brain research
pub_type： 杂志文章
doi：10.1016/j.bbr.2015.06.007
更新日期：2015-10-01 00:00:00
