Abstract:
:Pairing of the stimulus to the cerebral peduncle (CP) with that to the forearm skin leads cats to flex their forearms within a 10-day training period in response to stimulus to CP, which was initially ineffective. Behavioral study and extracellular unit analysis suggested that the cellular mechanism for this conditioning lies at the corticorubral (CR) synapses. Since formation of new CR synapses occurs in parallel with the recovery from behavioral deficits after brain damage and peripheral nerve cross-innervation, we explored the possibility that the formation of new CR synapses underlies conditioning. We investigated the time course of the CR excitatory postsynaptic potentials (EPSPs) as well as the distribution of the CR synapses on the somadendritic membrane of the red nucleus neurons and compared them with those observed in control animals. In conditioned animals, the times-to-peak of the CR EPSPs were significantly shorter than those in control animals. Electron microscopic studies demonstrated that more CR synapses make contact with large, i.e. proximal, dendrites and somata of red nucleus neurons in conditioned cats than in control ones. These results support the view that the formation of new synapses on the proximal dendrites and soma underlies classical conditioning in the cat.
journal_name
Behav Brain Resjournal_title
Behavioural brain researchauthors
Murakami F,Oda Y,Tsukahara Ndoi
10.1016/0166-4328(88)90094-0subject
Has Abstractpub_date
1988-04-01 00:00:00pages
175-9issue
1-2eissn
0166-4328issn
1872-7549pii
0166-4328(88)90094-0journal_volume
28pub_type
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