Abstract：
:Zinc is an important element in all cells of the body, having structural, enzymatic, and regulatory functions. In some neurons, zinc is loaded into synaptic vesicles by zinc transporter 3 (ZnT3) and released into the synaptic cleft, where it can modulate neuronal function. ZnT3 knockout (KO) mice lack ZnT3 and thus lack synaptic zinc. Previous studies have examined the behavioral phenotype of ZnT3 KO mice, mostly using mixed-sex or male-only groups. In the present study we focused specifically on the behavior of female ZnT3 KO mice (2-3 months old). An extensive battery of tests was administered to assess sensorimotor and cognitive behaviours, as well as to examine for a possible schizophrenia-like phenotype. ZnT3 KO mice performed similarly to wild type controls in the majority of tests. However, they were less accurate in the skilled reach task, suggesting impaired skilled motor learning, and faster to descend a vertical pole. ZnT3 KO mice were also slower in the open field and made fewer chamber entries in the social preference test, suggesting decreased exploratory locomotion. No differences were observed in the Morris water task or fear conditioning test. This is the first study to show a behavioural phenotype specifically for female ZnT3 KO mice. Comparing our results to previous studies, it appears that there may be sex-specific effects of eliminating ZnT3. Female ZnT3 KO mice exhibit abnormalities in locomotion and at skilled motor learning, but we were unable to detect spatial or fear learning deficits previously described in male ZnT3 KO mice.
journal_name
Behav Brain Resjournal_title
Behavioural brain researchauthors
Thackray SE,McAllister BB,Dyck RHdoi
10.1016/j.bbr.2016.12.028subject
Has Abstractpub_date
2017-03-15 00:00:00pages
36-49eissn
0166-4328issn
1872-7549pii
S0166-4328(16)30818-Xjournal_volume
321pub_type
杂志文章abstract：:Spatial orientation is considered to be an animal model of human cognitive functions. Efficient navigation is believed to require a brain representation of the environment. The role of NMDA-receptor-dependent neurotransmission in encoding spatial representations has been intensively studied; however, its involvement i...
journal_title：Behavioural brain research
pub_type： 杂志文章
doi：10.1016/j.bbr.2004.10.013
更新日期：2005-04-15 00:00:00
abstract：:Although the increasing rate of obesity has stimulated interest in the effects of diet composition on peripheral systems, comparatively little work has been done to examine effects upon the brain. A diet high in fat is one of many factors that can promote obesity, and previous research has shown that such a diet can p...
journal_title：Behavioural brain research
pub_type： 杂志文章
doi：10.1016/j.bbr.2006.09.010
更新日期：2006-12-15 00:00:00
abstract：:The effects of adrenalectomy and chronic corticosterone treatment on sexual behavior in the ovariectomized female rat were investigated. The serotonergic type 2A (5-HT2A) receptor-mediated behavior 'wet dog shakes' (WDS) was measured concurrently. In Experiment 1, adrenalectomy reduced the frequency of WDS following t...
journal_title：Behavioural brain research
pub_type： 杂志文章
doi：10.1016/s0166-4328(99)00046-7
更新日期：1999-10-01 00:00:00
abstract：:Chronic administration of a choline-deficient diet for 20 days caused no modification in ACh levels in the cortex, hippocampus and olfactory system of the rat and an increase in the density (Bmax) of the muscarinic receptors in the hippocampus. The choline-deficient diet caused no modification in noradrenaline levels ...
journal_title：Behavioural brain research
pub_type： 杂志文章
doi：10.1016/s0166-4328(96)00143-x
更新日期：1997-03-01 00:00:00
abstract：:We have previously demonstrated that kindling of the nucleus accumbens (NAc) induced psychosis relevant behaviors only after one, but not after five, stage-5 seizures, suggesting that five stage-5 NAc-evoked seizures antagonized psychosis relevant behaviors in rats. We hypothesized that brain opioid receptors are resp...
journal_title：Behavioural brain research
pub_type： 杂志文章
doi：10.1016/j.bbr.2018.09.007
更新日期：2019-01-01 00:00:00
abstract：:Metabolic consequences of morphine dependence and withdrawal intervention have not been well explored. In the present study, the metabolic changes in brain hippocampus, nucleus accumbens (NAc), prefrontal cortex (PFC) and striatum of rats with morphine dependence and withdrawal intervention were explored by using ¹H n...
journal_title：Behavioural brain research
pub_type： 杂志文章
doi：10.1016/j.bbr.2012.02.026
更新日期：2012-05-16 00:00:00
abstract：:Interocular transfer of the habituation to diffuse photic stimuli was demonstrated to be almost complete in pigeons. Birds submitted to visual Wulst ablation or supraoptic commissure lesion performed in much the same way. In contrast, when the tectal and posterior commissures were lesioned, pigeons failed to show inte...
journal_title：Behavioural brain research
pub_type： 杂志文章
doi：10.1016/0166-4328(87)90054-4
更新日期：1987-02-01 00:00:00
abstract：:Neural activation following sexual behavior was studied in the male and female rat brain, using Fos-immunoreactivity (Fos-IR) as a measure. In accordance with the available literature, we observed increased expression of c-fos in the medial preoptic nucleus (MPN), in the posteromedial subdivision of the bed nucleus of...
journal_title：Behavioural brain research
pub_type： 杂志文章
doi：10.1016/s0166-4328(97)00190-3
更新日期：1998-05-01 00:00:00
abstract：:Extensive evidence suggests that N-methyl-D-aspartate (NMDA) glutamate receptor channels in the amygdala are involved in fear-motivated learning, and infusion of NMDA receptor antagonists into the amygdala blocks memory of fear-motivated tasks. Recent studies have shown that previous training can prevent the amnestic ...
journal_title：Behavioural brain research
pub_type： 杂志文章
doi：10.1016/s0166-4328(00)00169-8
更新日期：2000-07-01 00:00:00
abstract：:The validity of the hypothesis put forward earlier, that testicular secretions during puberty have an organizing effect on open field ambulation was examined. Male rats were castrated or sham-operated at days 21, 43 or 70. At the age of 17 weeks the males were tested in an automated, octagonal open field (3 consecutiv...
journal_title：Behavioural brain research
pub_type： 杂志文章
doi：10.1016/0166-4328(88)90141-6
更新日期：1988-09-15 00:00:00
abstract：:Bilateral lesions were made, confined to the orbitofrontal part of the prefrontal cortex (OF) of male WEZOB rats at 3 different ages (30, 45 and 60 days) and behavioural changes were studied in adulthood. In a test situation for intermale aggression OF-lesioned animals showed a higher level of aggression than their co...
journal_title：Behavioural brain research
pub_type： 杂志文章
doi：10.1016/0166-4328(83)90032-3
更新日期：1983-12-01 00:00:00
abstract：:Male and female C57BL/6 J mice were tested on the predator odor response task, where they needed to cross through a chamber of scented bedding to reach a sucrose reward. Following the behavioral testing, mouse brains were immunohistochemically labeled for expression of the immediate early gene c-fos. In the presence o...
journal_title：Behavioural brain research
pub_type： 杂志文章
doi：10.1016/j.bbr.2020.112467
更新日期：2020-03-16 00:00:00
abstract：:Although both the presupplementary motor area (pre-SMA) and the right inferior frontal gyrus (rIFG) have been demonstrated to be critical for response inhibition, there is still considerable disagreement over the roles they play in the process. In the present study, we investigated the causal relations of the pre-SMA ...
journal_title：Behavioural brain research
pub_type： 杂志文章
doi：10.1016/j.bbr.2015.08.024
更新日期：2016-01-01 00:00:00
abstract：:In order to contribute to a better knowledge on the relationship between amyloid and tau pathology, and electroencephalography (EEG) disturbances, the aim of this study was to evaluate the effects of injection of beta amyloid Abeta(1-42) peptide, tau (a recombinant AAV (Adeno-Associated Virus) containing the human tra...
journal_title：Behavioural brain research
pub_type： 杂志文章
doi：10.1016/j.bbr.2018.10.026
更新日期：2019-02-01 00:00:00
abstract：:The lesion of the ventral mesencephalic tegmentum (VMT) and especially of the dopaminergic (DA) A10 neurons induced disturbances of spontaneous activity in the rat. Measured in different situations (circular corridor, open field, hole box), locomotor activity was dramatically and permanently increased (5 days of recor...
journal_title：Behavioural brain research
pub_type： 杂志文章
doi：10.1016/0166-4328(80)90024-8
更新日期：1980-08-01 00:00:00
abstract：:Elevated plus-maze (EPM) experienced rats show reduced open arms exploration in a subsequent EPM exposure, expressing the increased open arms avoidance which is characteristic of anxiety/fear-like behavior. The midbrain dorsal periaqueductal gray (dPAG) is an important integrative area of the neuroaxis able to control...
journal_title：Behavioural brain research
pub_type： 杂志文章
doi：10.1016/j.bbr.2009.09.001
更新日期：2010-01-05 00:00:00
abstract：:The aim of this study was to investigate the neural mechanisms underlying the changes in the ipsilateral primary motor cortex (ipsi-M1) excitability induced during the unilateral rhythmic muscle contraction of the first dorsal interosseous (FDI) (rhythmic contraction) muscle with three different frequencies of auditor...
journal_title：Behavioural brain research
pub_type： 杂志文章
doi：10.1016/j.bbr.2012.10.053
更新日期：2013-03-01 00:00:00
abstract：:The effects of the selective opiate kappa-receptor agonist tifluadom on memory were investigated in a passive avoidance task in 3 sets of experiments carried out with DBA/2 (DBA) mice both familiarized and unfamiliarized with the apparatus. In a first set of experiments, tifluadom (1.0 or 2.5, but not 0.5 mg/kg) admin...
journal_title：Behavioural brain research
pub_type： 杂志文章
doi：10.1016/0166-4328(85)90172-x
更新日期：1985-05-01 00:00:00
abstract：:We previously reported that the centrally acting non-narcotic antitussive, tipepidine, produces a novel antidepressant-like effect in the forced swimming test in rats, but the mechanism of the antidepressant-like effect of tipepidine is not clear. We investigated the pharmacological mechanism of the antidepressant-lik...
journal_title：Behavioural brain research
pub_type： 杂志文章
doi：10.1016/j.bbr.2011.09.031
更新日期：2012-01-15 00:00:00
abstract：:Depression and substance-abuse (e.g., cocaine) disorders are common concurrent diagnoses. In the present study, we combined bilateral olfactory bulbectomy (OBX) with a variety of procedures of intravenous cocaine self-administration and extinction/reinstatement in rats. We also investigated the effects of N-acetylcyst...
journal_title：Behavioural brain research
pub_type： 杂志文章
doi：10.1016/j.bbr.2014.02.044
更新日期：2014-06-01 00:00:00
abstract：:The plasticity of the nervous system is illustrated in the many new neuronal connections that are formed during the acquisition of behavioral skills, loss of function after brain injury, and subsequent recovery of function. The present review describes the acquisition of skilled reaching, the act of reaching for food ...
journal_title：Behavioural brain research
pub_type： 杂志文章,评审
doi：10.1016/j.bbr.2007.12.026
更新日期：2008-09-01 00:00:00
abstract：:Maternal separation has been associated with development of anxiety-like behaviour and learning impairments in adult rats. This has been linked to changes in brain morphology observed after exposure to high levels of circulating glucocorticoids during the stress-hyporesponsive period (P4-P14). In the present study, ad...
journal_title：Behavioural brain research
pub_type： 杂志文章
doi：10.1016/j.bbr.2010.02.045
更新日期：2010-07-29 00:00:00
abstract：:We have investigated the interaction between opioid peptides and dopaminergic A10 (DA-A10) neurones in the ventral tegmental area (VTA). The behavioural consequences of VTA infusion of d-Ala-Met-enkephalinamide (DALA) were analyzed. DALA elicited a dose-dependent increase in locomotor activity measured in photocell ca...
journal_title：Behavioural brain research
pub_type： 杂志文章
doi：10.1016/0166-4328(80)90043-1
更新日期：1980-02-01 00:00:00
abstract：:Norepinephrine (NE) is involved in a variety of behaviors across vertebrate species. In songbirds, NE is involved in singing and auditory perception, fundamental components of pair formation. Mechanisms of pairing remain poorly understood in avian species. NE is likely involved given its role in vocal communication an...
journal_title：Behavioural brain research
pub_type： 杂志文章
doi：10.1016/j.bbr.2013.05.056
更新日期：2013-09-01 00:00:00
abstract：:Many studies have demonstrated that stressors can modify the physiological action of drugs, mainly morphine. The present study investigated the effects of a mild stressor on chloral hydrate (Chl)-induced sedation in mice. For 4 consecutive days, NaCl and Chl-treated mice (300 mg kg(-1)) were stressed (S) either by a 5...
journal_title：Behavioural brain research
pub_type： 杂志文章
doi：10.1016/s0166-4328(00)00228-x
更新日期：2000-09-01 00:00:00
abstract：:Previous studies confirm that brief electrical stimulation of glutamatergic afferents from the ventral subiculum (vSub) can significantly enhance dopamine release in the ventral striatum for an extended duration (>20 min). However, the functional significance of this effect on motivated behavior remains to be specifie...
journal_title：Behavioural brain research
pub_type： 杂志文章
doi：10.1016/j.bbr.2018.09.002
更新日期：2019-01-01 00:00:00
abstract：:Rats were trained to respond to the lever above which a light stimulus was briefly (0.5 s) presented at unpredictable times. Once the task had been learned to criterion, subjects were injected, intra-peritoneally, with arginine8-vasopressin, desglycinamide arginine8-vasopressin (AVP or DGAVP: 0, 5, 10 or 20 micrograms...
journal_title：Behavioural brain research
pub_type： 杂志文章
doi：10.1016/0166-4328(88)90050-2
更新日期：1988-07-01 00:00:00
abstract：:In order to investigate the role of brain-derived neurotrophic factor (BDNF) in the consolidation of spatial memory, we examined the relationship between the increase of hippocampal BDNF and the establishment of long-term spatial memory in spontaneous place recognition test in rats. The test consisted of a sample phas...
journal_title：Behavioural brain research
pub_type： 杂志文章
doi：10.1016/j.bbr.2014.01.034
更新日期：2014-04-15 00:00:00
abstract：:Zebrafish are increasingly being used in behavioral neuroscience, neuropsychopharmacology and neurotoxicology. Recently, behavioral screens used to model anxiety in rodents were adapted to this species, and novel models which tap on zebrafish behavioral ecology have emerged. However, model building is an arduous task ...
journal_title：Behavioural brain research
pub_type： 杂志文章,评审
doi：10.1016/j.bbr.2010.05.031
更新日期：2010-12-25 00:00:00
abstract：:We review some of the evidence for structural changes in synapses in response to environmental stimulation. These include changes in synapse number, in distribution of presynaptic vesicles, in synaptic bouton size, and complex changes in the shape and size of synaptic contact zones. Increased numbers of postsynaptic p...
journal_title：Behavioural brain research
pub_type： 杂志文章,评审
doi：10.1016/0166-4328(94)00116-w
更新日期：1995-01-23 00:00:00
