当前位置： SCI文献检索 > BEHAVIOURAL BRAIN RESEARCH期刊下所有文献 > Locomotor hyperactivity and hypoexploration after lesion of the dopaminergic-A10 area in the ventral mesencephalic tegmentum (VMT) of rats.

Locomotor hyperactivity and hypoexploration after lesion of the dopaminergic-A10 area in the ventral mesencephalic tegmentum (VMT) of rats.

Abstract：

:The lesion of the ventral mesencephalic tegmentum (VMT) and especially of the dopaminergic (DA) A10 neurons induced disturbances of spontaneous activity in the rat. Measured in different situations (circular corridor, open field, hole box), locomotor activity was dramatically and permanently increased (5 days of recording) without modifications of the circadian rhythm, although exploratory patterns of behavior were reduced. In contrast, the administration of a low dose of D-amphetamine (1 and 2 mg/kg i.p.) to naïve rats induced an increase of both locomotor and exploratory activities. A qualitative analysis of spontaneous activity of rats after VMT lesions and after administration of D-amph, revealed opposing aspects of behavior. Residual response to D-amph of VMT-lesioned rats suggest a subtotal destruction of DA-A10 neurons, the implication of an over activity of these remaining DA-A10 neurons on behavioral deficit is considered. Our results can be explained by a deficiency in attention processes.

journal_name

Behav Brain Res

journal_title

Behavioural brain research

authors

Gaffori O,Le Moal M,Stinus L

doi

10.1016/0166-4328(80)90024-8

subject

Has Abstract

pub_date

1980-08-01 00:00:00

pages

313-29

issue

4

eissn

0166-4328

issn

1872-7549

pii

0166-4328(80)90024-8

journal_volume

1

pub_type

杂志文章

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