Abstract：
:The sensitivity of prenatally malnourished rats to the ultrasonic vocalization (USV) suppressant effect of diazepam (a non-specific benzodiazepine (BZ) receptor agonist) was investigated. Male offspring of dams provided with a protein deficient diet (6% casein) for 5 weeks prior to mating and throughout pregnancy were compared to the offspring of mothers provided with a diet of adequate protein content (25% casein). At postnatal day 7 or 11, pups were injected with vehicle or one of five doses of DZ (0.03, 0.1, 0.3, 1 or 3mg/kg) 30 min after removal from their dam. Thirty minutes later they were subjected to 2 min of cooling on a 20 degrees C surface and their USVs were quantified. DZ dose-dependently suppressed USV at both ages. At P7, the USV suppressant effect of DZ was the same for both groups. However, by P11 the prenatally malnourished rats showed significantly greater suppression of USV by 0.03 and 0.1mg/kg DZ than well-nourished controls. These differences were not related to degree of temperature loss or body weight. Thus, differential sensitivity to BZ receptor agonists develops in the second postnatal week in prenatally malnourished rats. This reflects either an altered program of development of the GABAergic system, or adaptive, compensatory changes in the GABAergic system in response to more extensive functional disturbances in the developing brain.
journal_name
Behav Brain Resjournal_title
Behavioural brain researchauthors
Tonkiss J,Galler Jdoi
10.1016/j.bbr.2006.11.018subject
Has Abstractpub_date
2007-09-04 00:00:00pages
337-43issue
2eissn
0166-4328issn
1872-7549pii
S0166-4328(06)00634-6journal_volume
182pub_type
杂志文章abstract：:The early detection of minor brain dysfunctions resulting from perinatal hypoxia is very important since the prognosis of the affected children can be substantially improved by a prompt treatment. Therefore, this paper deals with the influence of an early postnatal hypoxia on the postnatal development of spontaneous h...
journal_title：Behavioural brain research
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