Insular cortex lesions alter conditioned taste avoidance in rats differentially when using two methods of sucrose delivery.

Abstract:

:The insular gustatory cortex may be essential for the evaluation of saliency and representation of the incentive values of tastes. Gustatory cortex lesions should interfere with conditioned taste avoidance according to these factors, which depend on the conditioned taste avoidance protocol used. The present study was aimed at investigating the effects of bilateral lesions of the gustatory cortex-focusing on electrolytic and excitotoxic lesions. Lesioned and sham-operated male Long-Evans rats were intoxicated using LiCl after drinking sucrose from a tube (SD) or having the same amount of sucrose fed directly into their mouths through a chronically implanted intra-oral (IO) cannula. Every aspect of the experiment was carefully counterbalanced between the experimental groups. In the control groups, the acquired avoidance towards sucrose was strongly preserved over eight extinction test days in SD rats but not in IO rats, in which a progressive decline was recorded. Electrolytic gustatory cortex lesions impaired but did not suppress conditioned taste avoidance in both protocols. Excitotoxic lesions tend to impair CTA also, but differentially according to the SD or IO protocols. Extinction of CTA was selectively impaired in the SD protocol by small lesions destroying the anterior insular cortex.

journal_name

Behav Brain Res

authors

Fresquet N,Angst MJ,Sandner G

doi

10.1016/j.bbr.2003.12.011

subject

Has Abstract

pub_date

2004-08-31 00:00:00

pages

357-65

issue

2

eissn

0166-4328

issn

1872-7549

pii

S0166432803004807

journal_volume

153

pub_type

杂志文章
  • Conditioned place preference but not rewarding self-stimulation after electrical activation of the external lateral parabrachial nucleus.

    abstract::The objective of this experiment was to examine the rewarding effect of electrical stimulation of the external lateral parabrachial nucleus (LPBe) and of the lateral hypothalamus (LH) in concurrent Conditioned Place Preference (cCPP) and Brain Self-Stimulation Rewarding tasks. As expected, LH-stimulated animals readil...

    journal_title:Behavioural brain research

    pub_type: 杂志文章

    doi:10.1016/j.bbr.2009.07.028

    authors: Simon MJ,Molina F,Puerto A

    更新日期:2009-12-28 00:00:00

  • The neuroprotective effect of vitamin E on chronic sleep deprivation-induced memory impairment: the role of oxidative stress.

    abstract::Sleep deprivation induces oxidative stress and impairs learning and memory processes. Vitamin E, on the other hand, is a strong antioxidant that has neuroprotective effect on the brain. In this study, we examined the potential protective effect of chronic administration of vitamin E on chronic sleep deprivation-induce...

    journal_title:Behavioural brain research

    pub_type: 杂志文章

    doi:10.1016/j.bbr.2011.09.017

    authors: Alzoubi KH,Khabour OF,Rashid BA,Damaj IM,Salah HA

    更新日期:2012-01-01 00:00:00

  • Possible role of nitric oxide in the locomotor activity of hypertensive rats.

    abstract::We aimed to analyze whether hypertension and changes in nitric oxide (NO) generation are associated with alterations of locomotor activity in rats. Male Wistar rats treated with an inhibitor of NO synthase, NG-nitro-L-arginine methyl ester (L-NAME, 40 mg/kg/day) for 6 weeks, control Wistar rats, spontaneously hyperten...

    journal_title:Behavioural brain research

    pub_type: 杂志文章

    doi:10.1016/j.bbr.2006.07.021

    authors: Pechánová O,Jendeková L,Kojsová S,Jagla F

    更新日期:2006-11-01 00:00:00

  • The effect of reduced dopamine D4 receptor expression in the 5-choice continuous performance task: Separating response inhibition from premature responding.

    abstract::Impairments in attention/vigilance and response disinhibition are commonly observed in several neuropsychiatric disorders. Validating animal models could help in developing therapeutics for cognitive deficits and improving functional outcomes in such disorders. The 5-choice continuous performance test (5C-CPT) in mice...

    journal_title:Behavioural brain research

    pub_type: 杂志文章

    doi:10.1016/j.bbr.2011.03.054

    authors: Young JW,Powell SB,Scott CN,Zhou X,Geyer MA

    更新日期:2011-09-12 00:00:00

  • Sharing stressful experiences attenuates anxiety-related cognitive and sleep impairments.

    abstract::Anxiety is a growing public health concern that has been shown to impair both sleep and learning, and these associations have been extensively studied in recent years. In the rodent model, oftentimes various foot-shock paradigms are employed to induce stress, and subsequent sleep recordings and/or learning task result...

    journal_title:Behavioural brain research

    pub_type: 杂志文章

    doi:10.1016/j.bbr.2011.03.065

    authors: Macone BW,O'Malley M,Datta S

    更新日期:2011-09-23 00:00:00

  • Morphogenesis in memory formation: synaptic and cellular mechanisms.

    abstract::We review some of the evidence for structural changes in synapses in response to environmental stimulation. These include changes in synapse number, in distribution of presynaptic vesicles, in synaptic bouton size, and complex changes in the shape and size of synaptic contact zones. Increased numbers of postsynaptic p...

    journal_title:Behavioural brain research

    pub_type: 杂志文章,评审

    doi:10.1016/0166-4328(94)00116-w

    authors: Weiler IJ,Hawrylak N,Greenough WT

    更新日期:1995-01-23 00:00:00

  • Intrahippocampal bethanechol in rats: behavioural, electroencephalographic and neuropathological correlates.

    abstract::Unilateral microinjections of bethanechol chloride into the CA3 subfield of the dorsal hippocampus in unrestrained rats produced a seizure-related type behavioural and disseminated brain damage syndrome. Injection of bethanechol in the dose of 50 micrograms resulted in locomotor activation, mouth movements, teeth chat...

    journal_title:Behavioural brain research

    pub_type: 杂志文章

    doi:10.1016/0166-4328(83)90026-8

    authors: Turski WA,Cavalheiro EA,Turski L,Kleinrok Z

    更新日期:1983-03-01 00:00:00

  • Effects of chronic social stress in adolescence on anxiety and neuroendocrine response to mild stress in male and female rats.

    abstract::Using a rat model of adolescent social stress (SS, daily 1 h isolation and change of cage partner, 30-45 days of age), we have reported sex-specific effects on neuroendocrine function over the course of SS, and enduring effects of SS in females, and not males, on drug-related behaviour. Here, we investigated both the ...

    journal_title:Behavioural brain research

    pub_type: 杂志文章

    doi:10.1016/j.bbr.2007.09.005

    authors: McCormick CM,Smith C,Mathews IZ

    更新日期:2008-03-05 00:00:00

  • Anxiolytic action of urocortin 3 fragments in mice.

    abstract::In the present experiments, the anxiolytic action of Ucn 3 fragments were studied in an elevated plus maze in mice following icv administration in an attempt to identify the biologically active center of the molecule. Ucn 3, Ucn 3 (18-38), Ucn 3 (19-27), Ucn 3 (28-38), Ucn 3 (34-38), and Ucn 3 (36-38) but not Ucn 3 (3...

    journal_title:Behavioural brain research

    pub_type: 杂志文章

    doi:10.1016/j.bbr.2011.03.047

    authors: Telegdy G,Kádár K,Tóth G

    更新日期:2011-09-23 00:00:00

  • Effects of dopamine depletion from the caudate-putamen and nucleus accumbens septi on the acquisition and performance of a conditional discrimination task.

    abstract::Three experiments compared the effects of dopamine depletion from the caudate-putamen (CAUD; dorsal striatum) or nucleus accumbens septi (NAS; ventral striatum), or a systemically administered dopamine receptor antagonist (alpha-flupenthixol) on the acquisition and performance of a conditional discrimination task invo...

    journal_title:Behavioural brain research

    pub_type: 杂志文章

    doi:10.1016/0166-4328(90)90179-i

    authors: Robbins TW,Giardini V,Jones GH,Reading P,Sahakian BJ

    更新日期:1990-05-28 00:00:00

  • Phenotyping complex behaviours: assessment of circadian control and 5-choice serial reaction learning in the mouse.

    abstract::Currently, the behavioural phenotyping of mutant strains is restricted by the paucity of tests for the cognitive capabilities of mice. Most of the paradigms at present available such as the water maze or passive avoidance are dependent upon an aversive component for conditioning and as a consequence the data can often...

    journal_title:Behavioural brain research

    pub_type: 杂志文章

    doi:10.1016/s0166-4328(01)00300-x

    authors: Marston HM,Spratt C,Kelly JS

    更新日期:2001-11-01 00:00:00

  • Role of dorsal raphe nucleus GHS-R1a receptors in the regulation of inhibitory avoidance and escape behaviors in rats.

    abstract::Ghrelin is a recently discovered peptide, mainly produced in the stomach and involved in body's energy-maintenance processes. Ghrelin exerts its actions by activating the growth hormone secretagogue receptor (GHS-R). Recent analyses indicate that ghrelin targets the brain to regulate a wealth of functions, including b...

    journal_title:Behavioural brain research

    pub_type: 杂志文章

    doi:10.1016/j.bbr.2019.03.017

    authors: Cavalcante DP,Turones LC,Camargo-Silva G,Santana JS,Colugnati DB,Pansani AP,Xavier CH,Henschel Pobbe RL

    更新日期:2019-06-03 00:00:00

  • Viral-mediated expression of a constitutively active form of CREB in the dentate gyrus does not induce abnormally enduring fear memory.

    abstract::Increasing CREB-dependent transcription in dentate gyrus (DG) granule cells in vivo using viral-mediated expression of a constitutively active form of CREB (CREBCA) is sufficient to enhance contextual fear memory but whether this treatment renders memory abnormally enduring is unknown. Here we confirm that over-expres...

    journal_title:Behavioural brain research

    pub_type: 杂志文章

    doi:10.1016/j.bbr.2011.04.004

    authors: Vetere G,Marchetti C,Benevento M,Tafi E,Marie H,Ammassari-Teule M

    更新日期:2011-09-23 00:00:00

  • Electrical stimulation of insular cortex elicits cardiac inhibition but insular lesions do not abolish conditioned bradycardia in rabbits.

    abstract::Conscious rabbits received electrical stimulation of insular and more posterior perirhinal cortex through chronically implanted electrodes. Active sites for cardiovascular responses were found in both anterior and posterior insular cortex as well as more posterior perirhinal regions. Although differential response top...

    journal_title:Behavioural brain research

    pub_type: 杂志文章

    doi:10.1016/0166-4328(85)90025-7

    authors: Powell DA,Buchanan S,Hernàndez L

    更新日期:1985-09-01 00:00:00

  • Impairment of social behavior and communication in mice lacking the Uba6-dependent ubiquitin activation system.

    abstract::The Uba6-Use1 ubiquitin enzyme cascade is a poorly understood arm of the ubiquitin-proteasome system required for mouse development. Recently, we reported that Uba6 brain-specific knockout (termed NKO) mice display abnormal social behavior and neuronal development due to a decreased spine density and accumulation of U...

    journal_title:Behavioural brain research

    pub_type: 杂志文章

    doi:10.1016/j.bbr.2014.12.019

    authors: Lee JY,Kwak M,Lee PC

    更新日期:2015-03-15 00:00:00

  • Effects of maternal hyperleptinaemia during lactation on short-term memory/learning, anxiety-like and novelty-seeking behavioral traits of adult male rats.

    abstract::The objective of the present study was to evaluate whether maternal hyperleptinaemia programs anxiety-like and novelty-seeking behaviors as well as short-term memory/learning in adult male Wistar rats. During the first 10 days of lactation dams were s.c. injected with either murine leptin (LEP) or saline (CON). Adult ...

    journal_title:Behavioural brain research

    pub_type: 杂志文章

    doi:10.1016/j.bbr.2009.08.029

    authors: Fraga-Marques MC,Moura EG,Silva JO,Claudio-Neto S,Pereira-Toste F,Passos MC,Lisboa PC,Manhães AC

    更新日期:2010-01-05 00:00:00

  • Dopaminergic impact on local and global cortical circuit processing during learning.

    abstract::We have learned to detect, predict and behaviorally respond to important changes in our environment on short and longer time scales. Therefore, brains of humans and higher animals build upon a perceptual and semantic salience stored in their memories mainly generated by associative reinforcement learning. Functionally...

    journal_title:Behavioural brain research

    pub_type: 杂志文章,评审

    doi:10.1016/j.bbr.2015.11.016

    authors: Happel MF

    更新日期:2016-02-15 00:00:00

  • The problem of relating plasticity and skilled reaching after motor cortex stroke in the rat.

    abstract::The plasticity of the nervous system is illustrated in the many new neuronal connections that are formed during the acquisition of behavioral skills, loss of function after brain injury, and subsequent recovery of function. The present review describes the acquisition of skilled reaching, the act of reaching for food ...

    journal_title:Behavioural brain research

    pub_type: 杂志文章,评审

    doi:10.1016/j.bbr.2007.12.026

    authors: Whishaw IQ,Alaverdashvili M,Kolb B

    更新日期:2008-09-01 00:00:00

  • Vasopressin and amphetamine, but not desglycinamide vasopressin, impair positively reinforced visual attention performance in rats.

    abstract::Rats were trained to respond to the lever above which a light stimulus was briefly (0.5 s) presented at unpredictable times. Once the task had been learned to criterion, subjects were injected, intra-peritoneally, with arginine8-vasopressin, desglycinamide arginine8-vasopressin (AVP or DGAVP: 0, 5, 10 or 20 micrograms...

    journal_title:Behavioural brain research

    pub_type: 杂志文章

    doi:10.1016/0166-4328(88)90050-2

    authors: Sahgal A

    更新日期:1988-07-01 00:00:00

  • Generalization of effects of environmental enrichment on seeking for different classes of drugs of abuse.

    abstract:BACKGROUND:Addiction is a chronic disease characterized by persistent vulnerability to relapse during abstinence. In animal models of addiction, accumulating evidence suggests that exposure to environmental enrichment (EE) during periods of abstinence can have curative effects on addiction and reduce the risks of relap...

    journal_title:Behavioural brain research

    pub_type: 杂志文章

    doi:10.1016/j.bbr.2017.12.027

    authors: Sikora M,Nicolas C,Istin M,Jaafari N,Thiriet N,Solinas M

    更新日期:2018-04-02 00:00:00

  • H₂S attenuates cognitive deficits through Akt1/JNK3 signaling pathway in ischemic stroke.

    abstract::Neuronal damage in the hippocampal formation which is more sensitive to ischemic stimulation and easily injured will cause severe learning and memory impairment. Therefore, inhibiting hippocampal neuron injuries is the main contributor for learning and memory impairment during cerebral ischemia. Hydrogen sulfide (H2S)...

    journal_title:Behavioural brain research

    pub_type: 杂志文章

    doi:10.1016/j.bbr.2014.04.027

    authors: Wen X,Qi D,Sun Y,Huang X,Zhang F,Wu J,Fu Y,Ma K,Du Y,Dong H,Liu Y,Liu H,Song Y

    更新日期:2014-08-01 00:00:00

  • Maternal separation and maternal care act independently on the development of HPA responses in male rats.

    abstract::Postnatal manipulations such as brief (early handling, EH) and long, daily mother-offspring separations (maternal separation, MS) in rats are used to study the mechanisms underlying developmental plasticity of stress and fear responses, and to model stress-related disorders in humans and in non-human animals. Current ...

    journal_title:Behavioural brain research

    pub_type: 杂志文章

    doi:10.1016/j.bbr.2008.03.031

    authors: Macrì S,Chiarotti F,Würbel H

    更新日期:2008-08-22 00:00:00

  • Influence of light at night on murine anxiety- and depressive-like responses.

    abstract::Individuals are increasingly exposed to light at night. Exposure to constant light (LL) disrupts circadian rhythms of locomotor activity, body temperature, hormones, and the sleep-wake cycle in animals. Other behavioural responses to LL have been reported, but are inconsistent. The present experiment sought to determi...

    journal_title:Behavioural brain research

    pub_type: 杂志文章

    doi:10.1016/j.bbr.2009.07.001

    authors: Fonken LK,Finy MS,Walton JC,Weil ZM,Workman JL,Ross J,Nelson RJ

    更新日期:2009-12-28 00:00:00

  • Effects of nicotine exposure on locomotor activity and pCREB levels in the ventral striatum of adolescent rats.

    abstract::Behavioral reactivity to novel stimuli, which is greater in the adolescent than young adult population, is associated with drug abuse liability, suggesting that the increased addiction vulnerability of adolescents may be related to heightened novel stimulus reactivity and underlying cellular processes. We examined the...

    journal_title:Behavioural brain research

    pub_type: 杂志文章

    doi:10.1016/j.bbr.2012.01.036

    authors: Philpot RM,Engberg ME,Wecker L

    更新日期:2012-04-21 00:00:00

  • Proteomic and transcriptional profiling of rat amygdala following social play.

    abstract::Social play is the most characteristic form of social interaction which is necessary for adolescents to develop proper cognitive, emotional, and social competency. The information available on neural substrates and the mechanism involved in social play is limited. This study characterized social play by proteomic and ...

    journal_title:Behavioural brain research

    pub_type: 杂志文章

    doi:10.1016/j.bbr.2019.112210

    authors: Alugubelly N,Mohammad AN,Edelmann MJ,Nanduri B,Sayed M,Park JW,Carr RL

    更新日期:2019-12-30 00:00:00

  • 6-hydroxydopamine lesion in the A8 cell group of cats produces a short-lasting decreased accuracy in goal-directed forepaw-movements.

    abstract::Recently, feline studies have shown that a lesion in the retrorubral area, which includes the dopaminergic A8 cell group, produces motor programming deficits inherent to a hypofunction of the A9 system. A hypofunction in the striatal terminal area of A9 fibers, in turn, is known to produce a hypofunction of its first-...

    journal_title:Behavioural brain research

    pub_type: 杂志文章

    doi:10.1016/s0166-4328(99)00023-6

    authors: Arts MP,Cools AR

    更新日期:1999-08-01 00:00:00

  • Temporal patterns analysis of rat behavior in hole-board.

    abstract::The aim of present research was to analyze the temporal structure of rodent's anxiety-related behavior in hole-board apparatus (HB). Fifteen male Wistar rats were tested for 10 min. Video files, collected for each subject, were coded by means of a software coder and event log files generated for each subject. To asses...

    journal_title:Behavioural brain research

    pub_type: 杂志文章

    doi:10.1016/j.bbr.2009.11.013

    authors: Casarrubea M,Sorbera F,Magnusson M,Crescimanno G

    更新日期:2010-03-17 00:00:00

  • Neurobehavioural defects in adult mice neonatally exposed to nicotine: changes in nicotine-induced behaviour and maze learning performance.

    abstract::Neonatal exposure to low doses of nicotine has been shown to disturb the development of low-affinity nicotinic binding sites in the cerebral cortex and to elicit a deviant behavioural response to nicotine in adult mice. In this study, 10-day-old male NMRI mice were exposed to one of three different doses of nicotine (...

    journal_title:Behavioural brain research

    pub_type: 杂志文章

    doi:10.1016/s0166-4328(01)00207-8

    authors: Ankarberg E,Fredriksson A,Eriksson P

    更新日期:2001-09-14 00:00:00

  • Effects on subjective and objective alertness and sleep in response to evening light exposure in older subjects.

    abstract::Evening bright light exposure is reported to ameliorate daytime sleepiness and age-related sleep complaints, and also delays the timing of circadian rhythms. We tested whether evening light exposure given to older adults with sleep-wake complaints would delay the timing of their circadian rhythms with respect to their...

    journal_title:Behavioural brain research

    pub_type: 杂志文章

    doi:10.1016/j.bbr.2011.05.029

    authors: Münch M,Scheuermaier KD,Zhang R,Dunne SP,Guzik AM,Silva EJ,Ronda JM,Duffy JF

    更新日期:2011-10-31 00:00:00

  • Parietal and frontal contributions to episodic encoding of location.

    abstract::Specific contributions of frontal and parietal regions to visuospatial encoding and attention remain controversial. This study used fMRI to examine associative encoding of sequentially-presented spatial cues and object stimuli. The cue preceded the centrally-displayed object by a jittered-delay-interval to better isol...

    journal_title:Behavioural brain research

    pub_type: 杂志文章

    doi:10.1016/j.bbr.2012.12.048

    authors: Hales JB,Brewer JB

    更新日期:2013-04-15 00:00:00