Abstract：
:Despite extensive research on the relationship between acute stress and hippocampal function in adults, little is known about the short- and long-term effects of prolonged juvenile stress on learning, memory, and other hippocampal functions. This experiment investigated whether spatial learning would be altered in juvenile and adult rats previously exposed to a chronic stressor: 6 h of social isolation (SI) daily at 15-21 days of age. SI was found to increase circulating plasma levels of corticosterone (CORT) and allopregnanolone (3-alpha,5-alpha-pregnan-20-one; 3,5-THP) at 1 h after separation on the fourth day, indicating that the isolation was an effective stressor. When tested as juveniles (post-natal (PN) 22-24), spatial learning was impaired on the Morris water maze in the previously isolated subjects compared to non-isolated controls. However, when tested as adults (PN 92-94), subjects previously exposed to SI during the third week of life demonstrated more rapid learning of the task than controls. These results are discussed in light of research on the effects of CORT on the developing hippocampus.
journal_name
Behav Brain Resjournal_title
Behavioural brain researchauthors
Frisone DF,Frye CA,Zimmerberg Bdoi
10.1016/s0166-4328(01)00315-1subject
Has Abstractpub_date
2002-01-22 00:00:00pages
153-60issue
2eissn
0166-4328issn
1872-7549pii
S0166432801003151journal_volume
128pub_type
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journal_title：Behavioural brain research
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doi：10.1016/j.bbr.2008.10.031
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abstract：:Adaptively responding to acute stress has been of great importance for human and animal survival. However, for our species, stress-related disorders are putting an ever-increasing burden on healthcare systems. It is thus crucial to understand the basic processes and cognitive changes associated with acute stress. Here...
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