Abstract：
:Rats were trained to respond to the lever above which a light stimulus was briefly (0.5 s) presented at unpredictable times. Once the task had been learned to criterion, subjects were injected, intra-peritoneally, with arginine8-vasopressin, desglycinamide arginine8-vasopressin (AVP or DGAVP: 0, 5, 10 or 20 micrograms/kg) or D-amphetamine (AMP: 0, 0.75, 1.5 or 3 mg/kg) prior to test. Attention performance was assessed using several different indices, including percent corrects, sensitivity and responsivity measures derived from signal detection theory, the recently described probability of (response) repetition and switching, and latency to respond. AVP had a disruptive effect on percent corrects at the highest dose and increased response latencies, but DGAVP, which lacks pressor activity, had no behavioral effects. AMP markedly impaired most aspects of performance, and was the only substance to alter response strategies by inducing bias and repetitive responding. It is concluded that (1) contrary to some recent reports, visual attention is disrupted, not improved, by peripherally injected AVP, (2) these effects reflect pressor potency, (3) the disruption induced by AMP reflects response alterations, while the peptide probably affects more cognitive mechanisms, and (4) certain recently described indices are more sensitive than others in detecting response bias.
journal_name
Behav Brain Resjournal_title
Behavioural brain researchauthors
Sahgal Adoi
10.1016/0166-4328(88)90050-2subject
Has Abstractpub_date
1988-07-01 00:00:00pages
35-42issue
1-2eissn
0166-4328issn
1872-7549pii
0166-4328(88)90050-2journal_volume
29pub_type
杂志文章abstract：:We previously reported that voluntary intake of corn oil in the light box showed place preference in the conditioned place preference (CPP) test in mice. In the present study, we investigated the contribution of opioidergic systems to the corn oil-induced CPP in mice. Acquisition of the place preference by corn oil in...
journal_title：Behavioural brain research
pub_type： 杂志文章
doi：10.1016/s0166-4328(00)00388-0
更新日期：2001-06-01 00:00:00
abstract：:Heightened emotional states increase impulsive behaviors such as excessive ethanol consumption in humans. Though positive and negative affective states in rodents can be monitored in real-time through ultrasonic vocalization (USV) emissions, few animal studies have focused on the role of emotional status as a stimulus...
journal_title：Behavioural brain research
pub_type： 杂志文章
doi：10.1016/j.bbr.2016.01.042
更新日期：2016-04-01 00:00:00
abstract：:Simultaneous spatial-discrimination thresholds of 6 human subjects were measured at luminances between 0.2 and 2000 cd/m2. Subjects were tested on a forced-choice discrimination task which required them to distinguish between test and control stimuli of high contrast square-wave gratings with similar space-average lum...
journal_title：Behavioural brain research
pub_type： 杂志文章
doi：10.1016/0166-4328(84)90019-6
更新日期：1984-10-01 00:00:00
abstract：:Previous studies confirm that brief electrical stimulation of glutamatergic afferents from the ventral subiculum (vSub) can significantly enhance dopamine release in the ventral striatum for an extended duration (>20 min). However, the functional significance of this effect on motivated behavior remains to be specifie...
journal_title：Behavioural brain research
pub_type： 杂志文章
doi：10.1016/j.bbr.2018.09.002
更新日期：2019-01-01 00:00:00
abstract：:The one-trial object recognition task involves memory of a familiar object in parallel with the detection and encoding of a novel object. It provides the basis for the study of a wide range of cognitive and neuropsychological functions and processes in rats and mice. However, unlike in humans, primate and pigeon studi...
journal_title：Behavioural brain research
pub_type： 杂志文章,评审
doi：10.1016/j.bbr.2009.12.036
更新日期：2010-12-31 00:00:00
abstract：:Oxycodone and hydrocodone are opioids which are widely used for pain management and are also commonly misused and abused. The exposure to opioid analgesics has been associated with altered responses of D2-like dopamine receptors (D2DRs). Our recent results suggest that various opioids will differentially modulate the ...
journal_title：Behavioural brain research
pub_type： 杂志文章
doi：10.1016/j.bbr.2015.01.023
更新日期：2015-05-01 00:00:00
abstract：:Addiction is a behavioral disorder characterized by the compulsive seeking and taking of drugs despite serious negative consequences. In particular, the chronic use of drugs impairs memory and cognitive functions, which aggravates the loss of control over drug use and complicates treatment outcome. Therefore, cognitiv...
journal_title：Behavioural brain research
pub_type： 杂志文章,评审
doi：10.1016/j.bbr.2012.09.025
更新日期：2013-01-15 00:00:00
abstract：:Both normal and commissure-sectioned rabbits were examined over a variety of visual discrimination tasks. The visual displays were projected at various distances within the frontal visual field of the rabbit. The learning of either a black-white or a vertical-horizontal problem was found to be normal in commissure-cut...
journal_title：Behavioural brain research
pub_type： 杂志文章
doi：10.1016/0166-4328(83)90052-9
更新日期：1983-05-01 00:00:00
abstract：:Although exposure to acute stress has been shown to reinstate extinguished responding for a wide variety of drugs, no studies have investigated stress-induced reinstatement in animals with a history of 3,4-methylenedioxymethamphetamine (MDMA; ecstasy) self-administration. Thus, rats were trained to press a lever for M...
journal_title：Behavioural brain research
pub_type： 杂志文章
doi：10.1016/j.bbr.2015.07.056
更新日期：2015-11-01 00:00:00
abstract：:Microdialysis was used to study the effects of exposure to a male hamster on extracellular concentrations of dopamine, dihydroxyphenylacetic acid (DOPAC), homovanillic acid (HVA), and 5-hydroxyindole acetic acid (5-HIAA) in the ventral striatum of ovariectomized female Syrian hamsters pretreated with either estradiol ...
journal_title：Behavioural brain research
pub_type： 杂志文章
doi：10.1016/0166-4328(93)90111-3
更新日期：1993-06-30 00:00:00
abstract：:Oxytocin is an important messenger in the brain that has been linked to a variety of social functions in pharmacological studies. Besides, functional genetic variations on the oxytocin receptor gene have been repeatedly associated with social processing and functioning. Despite this knowledge, there are very few studi...
journal_title：Behavioural brain research
pub_type： 杂志文章
doi：10.1016/j.bbr.2017.04.036
更新日期：2017-06-30 00:00:00
abstract：:It has been observed that men and women show performance differences in the Iowa Gambling Task (IGT), a task of decision-making in which subjects through exploration learn to differentiate long-term advantageous from long-term disadvantageous decks of cards: men choose more cards from the long-term advantageous decks ...
journal_title：Behavioural brain research
pub_type： 杂志文章,评审
doi：10.1016/j.bbr.2012.10.002
更新日期：2013-02-01 00:00:00
abstract：:Autism is a heterogeneous, behaviorally defined developmental disorder with unknown etiology but thought to be the result of environmental insult acting upon the developing brain of a genetically susceptible individual. Approximately 30% of individuals with autism have normal development up to the age of about 30 mont...
journal_title：Behavioural brain research
pub_type： 杂志文章
doi：10.1016/j.bbr.2010.02.032
更新日期：2010-07-11 00:00:00
abstract：:The purpose of this study was to develop a model of unilateral cervical (C4-C5) spinal cord contusion injury in the rat and to characterize the functional and histological consequences following three injury levels using a new weight-drop spinal cord injury device. We evaluated forepaw/forelimb and hindlimb functions ...
journal_title：Behavioural brain research
pub_type： 杂志文章
doi：10.1016/s0166-4328(00)00328-4
更新日期：2001-02-15 00:00:00
abstract：:Weight gain and sexual dysfunction are serious side effects of certain antipsychotic drugs. Ziprasidone, a novel antipsychotic with a unique receptor binding profile, is reported to have a low propensity for such side effects. Previous results from this laboratory have demonstrated substantial weight gain following su...
journal_title：Behavioural brain research
pub_type： 杂志文章
doi：10.1016/j.bbr.2004.12.015
更新日期：2005-05-28 00:00:00
abstract：:Drug addiction is a chronic mental disorder characterized by frequent relapses. Contextual cues associated with drug use to play a critical causal role in drug-seeking behavior. The hippocampus has been implicated in encoding drug associative memories. Here we examine whether the dorsal hippocampus mediates context-in...
journal_title：Behavioural brain research
pub_type： 杂志文章
doi：10.1016/j.bbr.2020.112978
更新日期：2021-02-01 00:00:00
abstract：:The behavioral inhibition system (BIS) and the behavioral activation system (BAS) are two fundamental motivational systems which are not only responsible for affective states, behavior and personality, but also related to predispositions for various forms of psychopathology. A wide range of previous studies revealed s...
journal_title：Behavioural brain research
pub_type： 杂志文章
doi：10.1016/j.bbr.2014.08.041
更新日期：2014-11-01 00:00:00
abstract：:Testing of cognitive functions in rodent disease models constitutes a substantial sector of behavioral neuroscience. It is most often needed in phenotyping genetically modified new rodent (usually mouse) lines or in preclinical testing of cognitive effects of new CNS drugs. This review concerns present pitfalls and fu...
journal_title：Behavioural brain research
pub_type： 杂志文章,评审
doi：10.1016/j.bbr.2017.05.040
更新日期：2018-10-15 00:00:00
abstract：:In the present experiments, the anxiolytic action of Ucn 3 fragments were studied in an elevated plus maze in mice following icv administration in an attempt to identify the biologically active center of the molecule. Ucn 3, Ucn 3 (18-38), Ucn 3 (19-27), Ucn 3 (28-38), Ucn 3 (34-38), and Ucn 3 (36-38) but not Ucn 3 (3...
journal_title：Behavioural brain research
pub_type： 杂志文章
doi：10.1016/j.bbr.2011.03.047
更新日期：2011-09-23 00:00:00
abstract：:Despite considerable evidence for potential effects of estrogen on emotional processing, several studies of postmenopausal women who began hormone therapy (HT) remote from menopause report no effects of HT on emotional measures. As early HT initiation may preserve brain mechanisms, we examined effects of HT on emotion...
journal_title：Behavioural brain research
pub_type： 杂志文章
doi：10.1016/j.bbr.2011.09.012
更新日期：2012-01-01 00:00:00
abstract：:The median raphe nucleus (MR) has been shown to exert a powerful influence on behavioral arousal and marked locomotor hyperactivity can be produced by intra-MR injections of a variety of drugs including GABAA and GABAB agonists, excitatory amino acid antagonists, and μ- and δ-opioid agonists. Other studies have indica...
journal_title：Behavioural brain research
pub_type： 杂志文章
doi：10.1016/j.bbr.2013.12.004
更新日期：2014-03-15 00:00:00
abstract：:Environmental enrichment (EE) at early stages of neurodevelopment attenuates HI-induced behavioral, histological and cellular damage. However, the effects of EE exposure during gestational or early postnatal period and the possible influence of sexual dimorphism on EE protection are not fully understood. Present study...
journal_title：Behavioural brain research
pub_type： 杂志文章
doi：10.1016/j.bbr.2018.11.036
更新日期：2019-02-01 00:00:00
abstract：:Genetic variations of COMT and KIBRA, which were reported to be expressed in the hippocampus, have been linked to memory function. However, their interaction on the hippocampal structure remains unknown. This study aimed to explore the interaction effects of COMT rs4680 and KIBRA rs17070145 on the hippocampal subfield...
journal_title：Behavioural brain research
pub_type： 杂志文章
doi：10.1016/j.bbr.2020.112550
更新日期：2020-04-20 00:00:00
abstract：:Esthetic experience is a unique, affectively colored, self-transcending subject-object relationship in which cognitive processing is felt to flow differently than during everyday experiences. Notwithstanding previous multidisciplinary investigations, how esthetic experience modulates perception is still obscure. We us...
journal_title：Behavioural brain research
pub_type： 杂志文章
doi：10.1016/j.bbr.2014.09.041
更新日期：2015-02-01 00:00:00
abstract：:Effects of aspiration lesions of the cerebral cortex on the behavioral effects of intraventricular substantia nigra grafts were investigated. Apomorphine-induced rotational behavior consequent to unilateral lesions of the substantia nigra was used as a behavioral measure. Substantia nigra grafts reduced rotational beh...
journal_title：Behavioural brain research
pub_type： 杂志文章
doi：10.1016/s0166-4328(89)80060-9
更新日期：1989-04-01 00:00:00
abstract：:C57BL/6 (C57) and DBA/2 (DBA) inbred mice with posterior parietal cortex or sham lesions were tested in a radial eight-arm maze task with all the paths baited. In the high learner C57 strain, parietal lesions produced a limited impairment of performance without affecting maze-running strategies while the same lesions ...
journal_title：Behavioural brain research
pub_type： 杂志文章
doi：10.1016/s0166-4328(97)00213-1
更新日期：1998-09-01 00:00:00
abstract：:The hypothesis that changes in measured ground reaction forces and time parameters during locomotion can noninvasively detect Parkinsonism in unilateral 6-OH dopamine (6-OHDA) lesioned rats is tested. It was found that changes of seven locomotion parameters can be used to construct a logistic regression model with a d...
journal_title：Behavioural brain research
pub_type： 杂志文章
doi：10.1016/j.bbr.2010.02.012
更新日期：2010-06-26 00:00:00
abstract：:The phenomenon of dissociated memory retrieval is observed when some influences (for example, pharmacological) on the brain result in specific changes of long-term memory. The purpose of present paper is to reveal possibilities of the phenomenon for study of long-term memory retrieval. Pharmacologically-induced dissoc...
journal_title：Behavioural brain research
pub_type： 杂志文章
doi：10.1016/s0166-4328(99)00090-x
更新日期：1999-12-01 00:00:00
abstract：:Sexual imprinting is an early learning process by which young birds acquire the characteristics of a potential sexual partner. The physiological basis of this learning process is an irreversible reduction of dendritic spines in two forebrain areas, the LNM (lateral nido-mesopallium) and the MNM (medial nido-mesopalliu...
journal_title：Behavioural brain research
pub_type： 杂志文章
doi：10.1016/j.bbr.2006.03.034
更新日期：2006-07-15 00:00:00
abstract：:In recent years, the abuse of the club drug gamma-hydroxybutyrate (GHB) has become increasingly popular among adolescents. The drug induces euphoria but can also result in sedation, anaesthesia as well as short-term amnesia. In addition, the abuse of GHB causes cognitive impairments and the mechanism by which GHB indu...
journal_title：Behavioural brain research
pub_type： 杂志文章
doi：10.1016/j.bbr.2014.04.034
更新日期：2014-08-01 00:00:00
