Abstract:
:In drug dependence studies, rats are often tested daily with short breaks (such as weekends) spent untested in their home cages. Research on alcohol models has suggested that breaks from continuous testing can transiently enhance self-administration (termed the "alcohol deprivation effect"). The present study explored whether the salience of cocaine-access cues is increased after skipping weekend cocaine and cue exposures. Ultrasonic vocalizations (USVs) of the 50-kHz class are emitted by rats exposed to intravenous cocaine and have been shown to increase with repeated drug exposure at the same dose level (sensitization). The present study found that over the course of several weeks of cocaine self- or yoked-administration pre-drug cues signaling forthcoming access or delivery of cocaine elicited marked amounts of anticipatory 50-kHz USVs, and that weekend deprivation from cues and cocaine exaggerated further the level of calling (more calls on Mondays compared to Fridays). Anticipatory USVs extinguished less rapidly when weekend access to unreinforced cues was denied. The results may have clinical implications, in that intermittently avoiding cues or context may enhance drug cue salience and resistance to extinction.
journal_name
Behav Brain Resjournal_title
Behavioural brain researchauthors
Maier EY,Ahrens AM,Ma ST,Schallert T,Duvauchelle CLdoi
10.1016/j.bbr.2010.04.057subject
Has Abstractpub_date
2010-12-06 00:00:00pages
75-9issue
1eissn
0166-4328issn
1872-7549pii
S0166-4328(10)00339-6journal_volume
214pub_type
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