Abstract：
:Different strategies can be used to carry dopamine into the brain such as L-Dopa precursors or galactosilated form of DA (GAL-DA). The aim of this study was to investigate whether GAL-DA would reduce hyperactivity and increase non-selective attention (NSA) in a mouse model of attention deficit hyperactivity disorder (ADHD), as, i.e. C57BL/6 as did in NHE rats. Here we report that GAL-DA increases NSA in a spatial novelty in C57BL/6 mice. They received a single i.p. injection of GAL-DA (10 mg/kg or 100 mg/kg) or equimolar galactose vehicle. Another mouse strain the Swiss albino was introduced as inbred control group. Three hours after last injection mice were tested in a Làt-maze for 30-min. Behaviour was analyzed for horizontal (traveled distance) and vertical activity (orienting frequency and scanning durations) which shares cognitive and non-cognitive nature, respectively. Ten milligram per kilograms of GAL-DA, increases scanning duration in C57BL/6 mice. Thus a low dose of GAL-DA increases NSA without reducing hyperactivity in this mouse model of ADHD.
journal_name
Behav Brain Resjournal_title
Behavioural brain researchauthors
Ruocco LA,Viggiano D,Pignatelli M,Iannaccone T,Rimoli MG,Melisi D,Curcio A,De Lucia S,Carboni E,Gironi Carnevale UA,de Caprariis P,Sadile AGdoi
10.1016/j.bbr.2007.10.007subject
Has Abstractpub_date
2008-03-05 00:00:00pages
449-54issue
2eissn
0166-4328issn
1872-7549pii
S0166-4328(07)00540-2journal_volume
187pub_type
杂志文章abstract：:In the present study, the effects of post-training intra-dorsal hippocampal (intra-CA1) injection of an N-methyl-D-aspartate (NMDA) receptor agonist and competitive or noncompetitive antagonists, on memory retention of passive avoidance learning was measured in the presence and absence of physostigmine in rats. Intra-...
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