Abstract：
:Recent evidence shows that early life stress (ELS) is associated with altered resting-state functional connectivity (RSFC) between amygdala and the prefrontal cortex, as well as with maladaptive emotion regulation strategies and negative mood. However, the relation between ELS and maladaptive emotion regulation is not deterministic. Adaptive emotion regulation strategies such as reappraisal can also ensue from experience and learning in adulthood and can prevent negative mood. The present study aims to investigate the joint influence of ELS, in particular early-life emotional abuse (EA), and habitual use of reappraisal on amygdala-centered RSFC and mood. We examined amygdala-centered RSFC using functional magnetic resonance imaging (fMRI) in 28 healthy adults with varied exposure to early-life emotional abuse. We found that in subjects with high early-life emotional abuse, reappraisal was predominantly associated with RSFC between left centromedial amygdala (CMA) and the ventrolateral prefrontal cortex (VLPFC), whereas in subjects with low early-life EA reappraisal predominantly involved RSFC between right CMA, premotor and supplementary motor regions. For subjects with high EA, reappraisal use was associated with a decrease in negative mood whereas it was associated with an increase in positive mood for subjects with low EA. The general findings of the study suggest that reappraisal use might act as a protective factor, notably for individuals who were exposed to ELS, and that this is mediated by alteration of amygdala-centered RSFC.
journal_name
Behav Brain Resjournal_title
Behavioural brain researchauthors
El Khawli E,Fan Y,Aust S,Wirth K,Bönke L,Stevense A,Herrera A,Metz S,Loayza A,Bajbouj M,Grimm Sdoi
10.1016/j.bbr.2017.09.018subject
Has Abstractpub_date
2018-01-30 00:00:00pages
210-217eissn
0166-4328issn
1872-7549pii
S0166-4328(17)30963-4journal_volume
337pub_type
杂志文章abstract：:Neglect in human and non-human primates has been demonstrated following unilateral lesions of both posterior parietal and prefrontal areas. While it has now been well established that a unilateral lesion of the rodent analog of dorsolateral prefrontal cortex, medial agranular cortex (AGm), results in neglect, the effe...
journal_title：Behavioural brain research
pub_type： 杂志文章
doi：10.1016/0166-4328(93)90070-7
更新日期：1993-04-30 00:00:00
abstract：:A peripheral injection of glucose has been found to improve memory in rats, but the underlying mechanisms are unknown. One possible mechanism by which peripheral glucose might act on memory storage is by regulating ATP-sensitive potassium (K-ATP) channels. The present study investigated the effects of K-ATP channel mo...
journal_title：Behavioural brain research
pub_type： 杂志文章
doi：10.1016/s0166-4328(01)00242-x
更新日期：2001-11-29 00:00:00
abstract：:The effects on latent inhibition (LI; a delay in conditioning when a CS has been pre-exposed without consequences) of repeated restraint stress and the anxiolytic drug diazepam were examined in C57BL/6 mice to know whether previous aversive events or anxiolysis are factors determining the expression of LI. The LI mode...
journal_title：Behavioural brain research
pub_type： 杂志文章
doi：10.1016/j.bbr.2007.06.002
更新日期：2007-11-02 00:00:00
abstract：:Social isolation rearing (isolated condition, IC) is used as a model of early life stress in rodents. Rats raised in this condition are often compared to rats raised in an environmentally enriched condition (EC). However, EC rats are repeatedly exposed to forced novelty, another classic stressor in rodents. These stud...
journal_title：Behavioural brain research
pub_type： 杂志文章
doi：10.1016/j.bbr.2015.01.049
更新日期：2015-04-15 00:00:00
abstract：:We investigated sleep ontogenesis in the ferret-a placental mammal that is highly altricial compared to other mammalian species. Because altriciality is linked with elevated rapid-eye-movement (REM) sleep amounts during infancy, it was expected that ferret kits would display very high levels of this state. Longitudina...
journal_title：Behavioural brain research
pub_type： 杂志文章
doi：10.1016/j.bbr.2007.12.019
更新日期：2008-05-16 00:00:00
abstract：:The behavioral inhibition system (BIS) and the behavioral activation system (BAS) are two fundamental motivational systems which are not only responsible for affective states, behavior and personality, but also related to predispositions for various forms of psychopathology. A wide range of previous studies revealed s...
journal_title：Behavioural brain research
pub_type： 杂志文章
doi：10.1016/j.bbr.2014.08.041
更新日期：2014-11-01 00:00:00
abstract：:Excessive checking is a common, debilitating symptom of obsessive-compulsive disorder (OCD). In an established rodent model of OCD checking behaviour, quinpirole (dopamine D2/3-receptor agonist) increased checking in open-field tests, indicating dopaminergic modulation of checking-like behaviours. We designed a novel ...
journal_title：Behavioural brain research
pub_type： 杂志文章
doi：10.1016/j.bbr.2013.12.040
更新日期：2014-05-01 00:00:00
abstract：:It is generally assumed that if memory is disrupted by pharmacological inhibitors during its consolidation, it can be later acquired afresh. In our experiments, we trained day-old chicks in a one-trial passive avoidance task and interfered with memory formation using protein synthesis inhibitor anisomycin or NMDA rece...
journal_title：Behavioural brain research
pub_type： 杂志文章
doi：10.1016/j.bbr.2020.112695
更新日期：2020-07-15 00:00:00
abstract：:Single unit activity was recorded from the ventral part of the lateral geniculate nucleus (vLGN) in rats anaesthetized with urethane. Most of the cells located laterally in the nucleus were excited by light. The studied vLGN neurones did not respond to electrical stimulation of the tail, but about half of them changed...
journal_title：Behavioural brain research
pub_type： 杂志文章
doi：10.1016/s0166-4328(05)80294-3
更新日期：1992-09-28 00:00:00
abstract：:Alzheimer's disease (AD) is an irreversible, progressive brain disorder of the elderly characterized by learning and memory impairment. Stress level glucocorticoids (GCs) and β-amyloid (Aβ) peptides deposition are found to be correlated with dementia progression in patients with AD. However, little is known about the ...
journal_title：Behavioural brain research
pub_type： 杂志文章
doi：10.1016/j.bbr.2011.10.038
更新日期：2012-02-01 00:00:00
abstract：:There are reports that melatonin secretion from the pineal gland gradually diminishes with advancing age. It has been suggested that various forms of neuropsychiatric disease, in particular, Parkinson's disease (PD), is consequentially related to this decrease by virtue of increased oxidative stress which enhances the...
journal_title：Behavioural brain research
pub_type： 杂志文章
doi：10.1016/j.bbr.2004.11.030
更新日期：2005-05-07 00:00:00
abstract：:At present neurobiological interests are directing more attention towards the major role of the amygdalar GABA(A) receptor on orexin-dependent behaviors. This telencephalic region has been widely studied especially in view of its control on various psychiatric disorders such as anxiety and depression. Recently, cross-...
journal_title：Behavioural brain research
pub_type： 杂志文章
doi：10.1016/j.bbr.2010.11.014
更新日期：2011-04-15 00:00:00
abstract：:The human oculomotor system becomes active long before birth. At about 16 weeks (post-menstrual age) the first slow changes of eye position can be observed with the aid of real time ultrasonography. At 18-20 weeks more rapid eye movements are detectable. There is a gradual decline in the percentage of time spent in ra...
journal_title：Behavioural brain research
pub_type： 杂志文章
doi：10.1016/0166-4328(83)90157-2
更新日期：1983-10-01 00:00:00
abstract：:Social norms are a common motivator or de-motivator of behavior through the need of humans to comply with acceptable behaviors of their social groups. Converging evidence from functional neuroimaging and noninvasive brain stimulation studies suggest that the right dorsolateral prefrontal cortex (rDLPFC) is involved in...
journal_title：Behavioural brain research
pub_type： 杂志文章
doi：10.1016/j.bbr.2018.12.040
更新日期：2019-04-01 00:00:00
abstract：:The ability of the somatosensory cortex in differentiating various tactile sensations is very important for a person to perceive the surrounding environment. In this study, we utilize a lab-made multi-channel functional near-infrared spectroscopy (fNIRS) to discriminate the hemodynamic responses (HRs) of four differen...
journal_title：Behavioural brain research
pub_type： 杂志文章
doi：10.1016/j.bbr.2017.06.034
更新日期：2017-08-30 00:00:00
abstract：:Recent studies suggest a potential role for 5-hydroxytryptamine(6) (5-HT(6)) receptors in the regulation of addictive behavior. In the present study, our aim was to investigate whether the novel highly selective 5-HT(6) receptor antagonist compound (CMP) 42 affected nicotine and ethanol seeking behavior in Wistar rats...
journal_title：Behavioural brain research
pub_type： 杂志文章
doi：10.1016/j.bbr.2012.08.048
更新日期：2013-01-01 00:00:00
abstract：:Animals treated with unilateral 6-hydroxydopamine (6-ODHA) injections, an animal model of Parkinson's disease, exhibit deficits in memory for temporal order, but show intact novel object recognition. Since senktide, a potent neurokinin-3 receptor (NK3-R) agonist, has been shown to have promnestic effects in the aged r...
journal_title：Behavioural brain research
pub_type： 杂志文章
doi：10.1016/j.bbr.2014.06.006
更新日期：2015-05-15 00:00:00
abstract：:Specific contributions of frontal and parietal regions to visuospatial encoding and attention remain controversial. This study used fMRI to examine associative encoding of sequentially-presented spatial cues and object stimuli. The cue preceded the centrally-displayed object by a jittered-delay-interval to better isol...
journal_title：Behavioural brain research
pub_type： 杂志文章
doi：10.1016/j.bbr.2012.12.048
更新日期：2013-04-15 00:00:00
abstract：:Impairments in attention/vigilance and response disinhibition are commonly observed in several neuropsychiatric disorders. Validating animal models could help in developing therapeutics for cognitive deficits and improving functional outcomes in such disorders. The 5-choice continuous performance test (5C-CPT) in mice...
journal_title：Behavioural brain research
pub_type： 杂志文章
doi：10.1016/j.bbr.2011.03.054
更新日期：2011-09-12 00:00:00
abstract：:Many studies of creative cognition with a neuroimaging component now exist; what do they say about where and how creativity arises in the brain? We reviewed 45 brain-imaging studies of creative cognition. We found little clear evidence of overlap in their results. Nearly as many different tests were used as there were...
journal_title：Behavioural brain research
pub_type： 杂志文章,评审
doi：10.1016/j.bbr.2010.05.015
更新日期：2010-12-25 00:00:00
abstract：:Both normal and commissure-sectioned rabbits were examined over a variety of visual discrimination tasks. The visual displays were projected at various distances within the frontal visual field of the rabbit. The learning of either a black-white or a vertical-horizontal problem was found to be normal in commissure-cut...
journal_title：Behavioural brain research
pub_type： 杂志文章
doi：10.1016/0166-4328(83)90052-9
更新日期：1983-05-01 00:00:00
abstract：:Cholinergic dysfunction and deposition of plaques containing amyloid β-peptides (Aβ) are two of the characteristics of Alzheimer's disease. Here, we combine APPswe/PS1dE9 (APP/PS1) mice with the cholinergic immunotoxin mu p75-saporin (SAP) to integrate partial basal forebrain cholinergic degeneration and the neuropath...
journal_title：Behavioural brain research
pub_type： 杂志文章
doi：10.1016/j.bbr.2012.11.012
更新日期：2013-03-01 00:00:00
abstract：:Arylsulfatase A (ASA)-deficient mice represent an animal model for the lysosomal storage disorder metachromatic leukodystrophy (MLD). Although the model has been applied in pathophysiological and therapeutic studies, the behavioural phenotype of ASA(-/-) mice is only partially characterized, and the most decisive outc...
journal_title：Behavioural brain research
pub_type： 杂志文章
doi：10.1016/j.bbr.2008.01.008
更新日期：2008-06-03 00:00:00
abstract：UNLABELLED:Evidence from in situ studies supports the role of anti-apoptotic factors in the antidepressant responses of certain psychotropics. The availability of anti-ceramidase pro-apoptocic compound (LCL385) provides an opportunity to test in vivo the relation between hippocampal apopotosis and learned helplessness....
journal_title：Behavioural brain research
pub_type： 杂志文章
doi：10.1016/j.bbr.2008.07.040
更新日期：2009-01-30 00:00:00
abstract：:Injection of the GABA(A) receptor agonist muscimol into the nucleus accumbens shell (AcbSh) elicits robust feeding in satiated rats, but has no effect on water intake. The current study was designed to examine whether intra-AcbSh muscimol injections influence the intake of ethanol solutions in rats trained to drink us...
journal_title：Behavioural brain research
pub_type： 杂志文章
doi：10.1016/j.bbr.2010.08.032
更新日期：2011-01-20 00:00:00
abstract：:Cocaine dependence has been associated with deficits in white matter (WM) integrity. Nevertheless, what happens to WM integrity after long-term abstinence is not fully understood. To bridge this gap, changes in WM integrity were examined with diffusion tensor imaging (DTI) applied to 39 participants: 12 participants w...
journal_title：Behavioural brain research
pub_type： 杂志文章
doi：10.1016/j.bbr.2019.112388
更新日期：2020-02-03 00:00:00
abstract：:Elements of the septo-preoptic basal forebrain complex, particularly the lateral and medial septum, the diagonal band of Broca, and the magnocellular preoptic area, have been linked to medial forebrain bundle (MFB) self-stimulation. This study examines the roles of these areas in MFB self-stimulation by temporarily in...
journal_title：Behavioural brain research
pub_type： 杂志文章
doi：10.1016/j.bbr.2006.12.005
更新日期：2007-03-12 00:00:00
abstract：:Serotonin, acting through a cAMP-signaling pathway, delayed habituation to criterion of the leech's swim response to touch. This delay was reversed by crushing the connective between serotonin-exposed and serotonin-naive ganglia, and correlated with an increase in spontaneous impulse activity in this connective. We su...
journal_title：Behavioural brain research
pub_type： 杂志文章
doi：10.1016/j.bbr.2007.05.008
更新日期：2007-08-22 00:00:00
abstract：:The spatial learning ability of aged male and female Sprague-Dawley rats was assessed using the Morris water maze. To determine the influence of age-related visual deficits on performance levels, retinal morphologic measures were correlated with water maze performance for each rat. Rats were first trained on the water...
journal_title：Behavioural brain research
pub_type： 杂志文章
doi：10.1016/0166-4328(94)00167-e
更新日期：1995-06-01 00:00:00
abstract：:Cerebral hypoxia-ischemia can lead to motor and sensory impairments which can be dependent on the extent of infarcted regions. Since a better understanding of the neurochemical mechanisms involved in this injury is needed, the use of zebrafish as a cerebral hypoxia model has become quite promising because it could imp...
journal_title：Behavioural brain research
pub_type： 杂志文章
doi：10.1016/j.bbr.2013.07.019
更新日期：2013-09-15 00:00:00
